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Endothelium-Dependent Relaxing Factors (Endothelium Derived Relaxing Factor)

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Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been identified, including NITRIC OXIDE and PROSTACYCLIN.

Also Known As:

Endothelium Derived Relaxing Factor; Endothelium-Dependent Relaxing Factor; Endothelium-Dependent Vasodilators; Endothelium-Derived Relaxant Factor; Neutrophil-Derived Relaxant Factor; Endothelium Dependent Relaxing Factor; Endothelium Dependent Relaxing Factors; Endothelium Dependent Vasodilators; Endothelium Derived Relaxant Factor; Factor, Neutrophil-Derived Relaxant; Neutrophil Derived Relaxant Factor; Relaxant Factor, Endothelium-Derived; Relaxant Factor, Neutrophil-Derived; Relaxing Factor, Endothelium-Dependent; Relaxing Factor, Endothelium-Derived; Relaxing Factors, Endothelium-Dependent; Vasodilators, Endothelium-Dependent; Endothelium-Derived Relaxing Factor

Networked: 311 relevant articles (3 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Therapeutic Uses: 297
    - Cardiovascular Agents: 355
      - Vasodilator Agents: 2287
        Endothelium-Dependent Relaxing Factors: 311

Experts

1.	Iadecola, Costantino: 2 articles (06/2014 - 01/2011)
2.	Park, Laibaik: 2 articles (06/2014 - 01/2011)
3.	Stocker, Roland: 2 articles (12/2011 - 03/2010)
4.	Wang, Yutang: 2 articles (12/2011 - 03/2010)
5.	Celermajer, David S: 2 articles (12/2011 - 03/2010)
6.	Changsirivathanathamrong, Dechaboon: 2 articles (12/2011 - 03/2010)
7.	Wanstall, Janet C: 2 articles (01/2004 - 09/2003)
8.	Li, Min: 1 article (08/2015)
9.	Quan, Shichao: 1 article (08/2015)
10.	Wang, Yuanyuan: 1 article (08/2015)

Related Diseases

1.	Atherosclerosis 01/01/1989 - "The present studies were performed to determine if abnormal endothelium-dependent vascular relaxation in atherosclerosis is due to decreased production or release of endothelium-derived relaxing factor (EDRF) by atherosclerotic rabbit vessels or if atherosclerotic vessels are less sensitive to the relaxing effects of EDRF. " 02/01/1988 - "This study was undertaken to determine whether atherosclerosis impairs relaxations mediated by endothelium-derived relaxing factor (EDRF) in human coronary arteries. " 12/01/1987 - "Because the intima remains thickened after regression of atherosclerosis, these studies suggest that intimal thickening which is present in both atherosclerotic vessels and after regression of atherosclerosis does not prevent the endothelium-derived relaxing factor from reaching the underlying vascular smooth muscle." 03/01/1998 - "It has also been demonstrated that there is a greater basal release of endothelium derived relaxing factor (EDRF) in female as compared to male rabbit aorta, which also might have beneficial effects in atherosclerosis. " 11/01/1997 - "Atherosclerosis is associated with reduced endothelium-derived relaxing factor bioactivity. "
2.	Hypertension (High Blood Pressure) 12/01/2006 - "Clinical studies have shown that patients with hypertension have a blunted arterial vasodilatory response to infusion of endothelium-dependent vasodilators and that inhibition of NO raises blood pressure. " 01/01/2011 - "ANG II attenuated the cerebral blood flow increase induced by neural activity (whisker stimulation) or endothelium-dependent vasodilators, an effect observed before the AP elevation (7 days), as well as after the hypertension subsided (21 days). " 09/01/1997 - "Diminished vasodilatory response to endothelium-derived relaxing factor (EDRF) does not seem to be associated with the increased prevalence of hypertension in blacks." 01/01/1995 - "We conclude that PTH plays an important role in the development of hypertension, through modulating the release of endothelium-derived relaxing factor, in young SHR." 01/01/1994 - "In this work we sought to characterize the contribution of endothelium-derived relaxing factor (EDRF) release to this effect which is not linked to hypertension. "
3.	Hypercholesterolemia 08/01/1995 - "A hallmark of endothelial cells exposed to hypercholesterolemia is a reduced capacity to release endothelium-derived relaxing factor. " 12/01/1993 - "These results demonstrate that hypercholesterolemia in humans does not impair endothelium-derived relaxing factor-mediated venodilation." 12/01/1993 - "Patients with hypercholesterolemia have a reduced response to endothelium-dependent vasodilators. " 03/01/1991 - "Reduced synthesis of endothelium-derived relaxing factor (EDRF) may explain impaired endothelium-dependent vasodilation in hypercholesterolemia. " 12/01/1990 - "In hypercholesterolemia, resistance vessels do not relax normally in response to pharmacological stimuli that release endothelium-derived relaxing factor; bioassay experiments have suggested that impaired synthesis or release of endothelium-derived relaxing factor accounts, in part, for this blunted relaxation. "
4.	Chronic Kidney Failure (Chronic Renal Failure) 09/01/2006 - "Wenpi decoction ameliorates the harmful factors of chronic renal failure, such as mesangial matrix and its cytokines, nuclear factor, endothelium-dependent relaxing factor, oxidative free raidical, apoptosis, lipide, protein, and blood rheology. "
5.	Heart Failure 12/01/1995 - "The aim of this study was to establish whether endothelium-derived relaxing factor (EDRF) influences the distensibility of conduit arteries and whether endothelium-mediated increases in distensibility are impaired in chronic heart failure (CHF). " 10/01/1994 - "In the present study, we used dogs with chronic heart failure to investigate whether endothelium-dependent vasodilation in the resistance vessels in the hindlimb is decreased in chronic heart failure, and if so, to determine if endothelium-derived relaxing factor (EDRF) is involved in the mechanism. " 06/01/1993 - "This study examines the biological effects of atrial natriuretic peptide and endothelium derived relaxing factor in experimental heart failure by assessing the plasma, urinary, and tissue concentrations of their common second messenger cGMP. " 10/01/1991 - "This study was undertaken to evaluate whether a specific local mechanism, namely endothelium-derived relaxing factor (EDRF) activity, might be impaired in an experimental model of chronic heart failure. " 12/01/2001 - "The increase in coronary blood flow (CBF) in response to endothelium-dependent vasodilators is reduced in congestive heart failure (CHF) suggesting endothelial dysfunction. "

Related Drugs and Biologics

1.	Nitric Oxide (Nitrogen Monoxide)
2.	Cytokines
3.	Cod Liver Oil
4.	wenpi decoction
5.	Acetylcholine (Acetylcholine Chloride)
6.	Bradykinin
7.	Arginine (L-Arginine)
8.	Norepinephrine (Noradrenaline)
9.	Nitroprusside (Sodium Nitroprusside)
10.	Oxygen

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Angioplasty (Angioplasty, Transluminal)
3.	Surgical Instruments (Clip)
4.	Lasers (Laser)
5.	Parathyroidectomy