Reticulocytosis

An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.

Also Known As:

Networked: 382 relevant articles (11 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemolysis
2.	Anemia
3.	Leukemia
4.	Viremia
5.	Thrombocytopenia (Thrombopenia)

Experts

1.	Stevenson, Mary M: 3 articles (01/2014 - 02/2004)
2.	Tam, Mifong: 3 articles (01/2014 - 02/2004)
3.	Tavrovskaya, T V: 2 articles (01/2015 - 10/2013)
4.	Miller, Jeffery L: 2 articles (01/2015 - 01/2013)
5.	Novozhilov, A V: 2 articles (01/2015 - 10/2013)
6.	Lee, Y Terry: 2 articles (01/2015 - 01/2013)
7.	Morozov, V I: 2 articles (01/2015 - 10/2013)
8.	Meier, Emily Riehm: 2 articles (01/2015 - 01/2013)
9.	Byrnes, Colleen: 2 articles (01/2015 - 01/2013)
10.	Voitenko, N G: 2 articles (01/2015 - 10/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Reticulocytosis:

1.	Hemoglobins (Hemoglobin)IBA 09/01/1990 - "A rapid and marked reticulocytosis was seen from a week later and there was a rapid increase in hemoglobin levels, and remission has been maintained for over 22 months. " 01/01/2013 - "The hemoglobin (Hb) levels in the four patients ranged from 4.2 to 8.2 g/dL and they all had reticulocytosis (10.0 to 31.0%). " 01/01/2012 - "All treatments resulted in lower hemoglobin concentrations, enhanced erythropoiesis in the spleen and reticulocytosis. " 06/01/2011 - "Laboratory tests showed hematocrit 14%; hemoglobin 4.8 g/dL; platelet count 6000/mm(3), and reticulocytosis 6%. " 08/01/2008 - "Blood complete picture showed decreased hemoglobin and reticulocytosis upto 30%. "
2.	Vitamin EFDA LinkGeneric 11/01/1977 - "Supplementation with vitamin E resulted in reticulocytosis and a return of the normal bone marrow picture." 01/01/1988 - "In the meanwhile, the vitamin E supplementation led to reduced reticulocytosis and control % hemolysis." 08/21/1980 - "Three months of vitamin E administration resulted in decreased chronic hemolysis as evidenced by improved red-cell life span (P less than 0.025), with an improvement in red-cell half-life from 22.9 +/- 0.7 days to 25.1 +/- 0.6 days (mean +/- S.E.M.), increased hemoglobin concentration (P less than 0.001), and decreased reticulocytosis (P less than 0.001) as compared with base-line values. " 11/01/1980 - "These patients respond with reticulocytosis and a limited increase in hemoglobin concentration when vitamin E is given before their metabolic derangement is reversed by correcting their other nutritional deficiencies. " 10/01/1986 - "In males, high levels of vitamin E (2000 mg/kg) caused prolongation of both prothrombin and activated partial thromboplastin (APTT) times, reticulocytosis and a decrease in haematocrit values and haemoglobin concentrations. "
3.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/01/1986 - "Treatment of the patient with cyclophosphamide and corticosteroids reduced marrow lymphocytes fourfold, and a prompt reticulocytosis ensued. " 05/01/1981 - "Treatment with cyclophosphamide and prednisone induced reticulocytosis in all four CLL-PRCA patients. " 01/01/1985 - "After six weeks treatment including steroids, cyclophosphamide and three courses of plasma exchange without improvement, surgical thymectomy was followed by a reticulocytosis and remission of the red cell aplasia. " 08/11/1978 - "With substitution of cyclophosphamide therapy for azathioprine, erythroid hyperplasia and reticulocytosis developed at three weeks in one patient and at three months in the other. " 02/01/1973 - "When the red cell aplasia was treated with cyclophosphamide and prednisone, marrow cell incorporation of (59)Fe into heme in vitro increased several weeks before a reticulocytosis was apparent, and was the earliest effect noted. "
4.	gamma-GlobinsIBA 03/01/1985 - "The persistence of reticulocytosis throughout the treatment with azaC or d-azaC makes it appear likely that the observed increase in Hb F levels to more than 60% of total hemoglobin is not due to a cytotoxic effect on erythropoiesis resulting in a shift of cell populations toward greater immaturity, but to a direct influence of the drug on the regulation of gamma globin chain production." 05/15/2001 - "Human gamma-globin messenger RNA (mRNA) expression at 7% of the level of total endogenous alpha-globin mRNA in thalassemic erythroid cells resulted in improved red cell morphology, a greater than 2-g/dL increase in Hb, and diminished reticulocytosis and extramedullary erythropoiesis. " 09/05/2005 - "Scriptaid induced reticulocytosis and human gamma-globin mRNA synthesis. "
5.	SodiumIBA 01/01/1990 - "Only a slight reticulocytosis was observed in these animals although their erythrocytes showed a marked decrease in their ability to extrude sodium actively. " 04/01/1981 - "Calcium and sodium permeability of erythrocytes from patients with untransfused alpha- or beta- thalassemia major has been studied and compared to mature erythrocytes or control cells with comparable reticulocytosis. " 02/01/1988 - "5. The increases in Na+,K+-ATPase in pregnancy were not closely related to the concomitant increases in aldosterone or cholesterol nor to reticulocytosis and were not affected by 7 days of high (greater than 250 mmol/day) or low (less than 50 mmol/day) sodium intake."
6.	Messenger RNA (mRNA)IBA 08/29/2013 - "Increased levels of circulating Epo lead to reticulocytosis, polycythemia, and suppression of hepatic hepcidin mRNA. " 05/15/2001 - "Human gamma-globin messenger RNA (mRNA) expression at 7% of the level of total endogenous alpha-globin mRNA in thalassemic erythroid cells resulted in improved red cell morphology, a greater than 2-g/dL increase in Hb, and diminished reticulocytosis and extramedullary erythropoiesis. " 09/05/2005 - "Scriptaid induced reticulocytosis and human gamma-globin mRNA synthesis. "
7.	Prednisone (Sone)FDA LinkGeneric 05/01/1981 - "Treatment with cyclophosphamide and prednisone induced reticulocytosis in all four CLL-PRCA patients. " 10/01/1986 - "Children with acute leukemia in remission manifest reticulocytosis and a significant increase in hemoglobin concentration (mean increment of 2.3 +/- 1.1 g/dl) following prednisone pulse therapy. " 02/01/1973 - "When the red cell aplasia was treated with cyclophosphamide and prednisone, marrow cell incorporation of (59)Fe into heme in vitro increased several weeks before a reticulocytosis was apparent, and was the earliest effect noted. "
8.	LectinsIBA 06/01/1984 - "A selective and significant reduction in the density of WGA receptors, but not other lectins was noted congruent to the degree of reticulocytosis. " 02/01/1986 - "A similar effect was indicated with erythrocytes obtained during an acute Anaplasma marginale infection; however, an ensuing reticulocytosis masked the effect, requiring the use of fluoresceinated lectins to verify that increased binding of each lectin occurred with infected cells when compared to normal cells."
9.	CopperIBA 03/01/1994 - "A marked reticulocytosis occurred after 10 days of copper supplementation, and his anemia gradually improved over the next 3 months. " 03/15/1985 - "Oral zinc therapy was stopped and intravenous supplements of copper were followed by reticulocytosis and complete correction of the anemia and granulocytopenia. "
10.	alpha-GlobinsIBA 05/15/2001 - "Human gamma-globin messenger RNA (mRNA) expression at 7% of the level of total endogenous alpha-globin mRNA in thalassemic erythroid cells resulted in improved red cell morphology, a greater than 2-g/dL increase in Hb, and diminished reticulocytosis and extramedullary erythropoiesis. "

Therapies and Procedures

1.	Retreatment 10/01/1985 - "Within 4-6 months, they relapsed, and after retreatment with ATG both again developed reticulocytosis and remission. "
2.	Thymectomy 01/01/1985 - "After six weeks treatment including steroids, cyclophosphamide and three courses of plasma exchange without improvement, surgical thymectomy was followed by a reticulocytosis and remission of the red cell aplasia. "
3.	Plasmapheresis 04/01/2008 - "Immediately following plasmapheresis, the patient demonstrated clinical improvement followed by attenuation of the hemolysis and improved reticulocytosis. "
4.	Plasma Exchange 01/01/1985 - "After six weeks treatment including steroids, cyclophosphamide and three courses of plasma exchange without improvement, surgical thymectomy was followed by a reticulocytosis and remission of the red cell aplasia. "
5.	Injections 07/10/2000 - "Peak reticulocytosis was noted on days 2 and 4 for all three vanadium-treated groups; for V-IV and V-V the increase continued to day 6. Radioiron data showed an erythropoietic stimulation by a significant increase in uptake percentages on days 4-6 after vanadium injections compared to saline-treated controls." 01/01/1991 - "Reticulocytosis was induced in 14 guinea pigs by phenylhydrazine hydrochloride injections for 5 consecutive days followed by 2 days of rest. " 08/13/1975 - "Reticulocytosis has been induced in rabbits by phelbotomy and phenylhydrazine injections. " 09/01/1936 - "RETICULOCYTOSIS IN THE GUINEA PIG FOLLOWING INJECTIONS OF GASTRIC JUICE AND CONGO RED." 01/01/1996 - "The subsequent infection was followed for ANKA in normal mice and for NK65 in normal mice and in mice with high-grade reticulocytosis induced by injections of phenylhydrazine. "