Reticulocytosis

An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.

Also Known As:

Networked: 507 relevant articles (15 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Anemia
2.	Hemolysis
3.	Hyperbilirubinemia
4.	Pernicious Anemia
5.	Leukemia

Experts

1.	Little, Jane A: 3 articles (11/2020 - 09/2016)
2.	Meier, Emily Riehm: 3 articles (01/2020 - 01/2013)
3.	Kalfa, Theodosia A: 3 articles (01/2019 - 12/2006)
4.	Stevenson, Mary M: 3 articles (01/2014 - 02/2004)
5.	Tam, Mifong: 3 articles (01/2014 - 02/2004)
6.	Luzzatto, Lucio: 2 articles (01/2021 - 01/2016)
7.	Gurkan, Umut A: 2 articles (11/2020 - 06/2018)
8.	Ilich, Anton: 2 articles (11/2020 - 06/2018)
9.	Key, Nigel S: 2 articles (11/2020 - 06/2018)
10.	Kucukal, Erdem: 2 articles (11/2020 - 06/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Reticulocytosis:

1.	Hemoglobins (Hemoglobin)IBA 09/01/1990 - "A rapid and marked reticulocytosis was seen from a week later and there was a rapid increase in hemoglobin levels, and remission has been maintained for over 22 months. " 07/25/2022 - "Rapid reticulocytosis with slow incrementation of his hemoglobin were observed over one month. " 10/01/2018 - "Meanwhile the measurement of HbA1c, 8/16 patients had hemoglobin level lower than 100 g/L and 5/6 presented with reticulocytosis (>100 G/L). " 12/01/2015 - "Positive cases displayed increased reticulocytosis and slightly reduced hemoglobin (Hb) values compared to negative ones. " 01/01/2013 - "The hemoglobin (Hb) levels in the four patients ranged from 4.2 to 8.2 g/dL and they all had reticulocytosis (10.0 to 31.0%). "
2.	alpha-GlobinsIBA 02/01/1996 - "Reticulocytosis was decreased from a mean (+/- SD) of 18.0% +/- 15.6% to 11.7% +/- 9.1% (P < .05); there was also a slight (10%) but statistically significant increase in hemoglobin levels and an improved balance in alpha:non-alpha globin chains ratios. " 05/15/2001 - "Human gamma-globin messenger RNA (mRNA) expression at 7% of the level of total endogenous alpha-globin mRNA in thalassemic erythroid cells resulted in improved red cell morphology, a greater than 2-g/dL increase in Hb, and diminished reticulocytosis and extramedullary erythropoiesis. "
3.	Vitamin EFDA LinkGeneric 02/01/2018 - " Low hematocrit and reticulocytosis before vitamin E administration were associated with adequate response to treatment. " 11/01/1977 - "Supplementation with vitamin E resulted in reticulocytosis and a return of the normal bone marrow picture." 01/01/1988 - "In the meanwhile, the vitamin E supplementation led to reduced reticulocytosis and control % hemolysis." 08/21/1980 - "Three months of vitamin E administration resulted in decreased chronic hemolysis as evidenced by improved red-cell life span (P less than 0.025), with an improvement in red-cell half-life from 22.9 +/- 0.7 days to 25.1 +/- 0.6 days (mean +/- S.E.M.), increased hemoglobin concentration (P less than 0.001), and decreased reticulocytosis (P less than 0.001) as compared with base-line values. " 02/01/2018 - "Those with anemia, reticulocytosis, and oxygen requirement may benefit from additional vitamin E."
4.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/01/1986 - "Treatment of the patient with cyclophosphamide and corticosteroids reduced marrow lymphocytes fourfold, and a prompt reticulocytosis ensued. " 05/01/1981 - "Treatment with cyclophosphamide and prednisone induced reticulocytosis in all four CLL-PRCA patients. " 01/01/1985 - "After six weeks treatment including steroids, cyclophosphamide and three courses of plasma exchange without improvement, surgical thymectomy was followed by a reticulocytosis and remission of the red cell aplasia. " 08/11/1978 - "With substitution of cyclophosphamide therapy for azathioprine, erythroid hyperplasia and reticulocytosis developed at three weeks in one patient and at three months in the other. " 02/01/1973 - "When the red cell aplasia was treated with cyclophosphamide and prednisone, marrow cell incorporation of (59)Fe into heme in vitro increased several weeks before a reticulocytosis was apparent, and was the earliest effect noted. "
5.	Coloring Agents (Dyes)IBA 06/13/2002 - "AHSP-gene-ablated mice exhibit reticulocytosis and abnormal erythrocyte morphology with intracellular inclusion bodies that stain positively for denatured haemoglobins. " 08/16/1935 - "A COLLOIDAL DYE EFFECTIVE IN TREATING PERNICIOUS ANEMIA AND EVOKING RETICULOCYTOSIS IN GUINEA PIGS." 01/01/1995 - "Thiazole orange dye showed distinct peaks corresponding to aggregate and punctate reticulocytes from specimens with marked reticulocytosis. " 01/01/1996 - "Specific effects of dispersed nitro dyes and semiproducts of their synthesis on the red blood were methemoglobin formation, suppressed antioxidant activity of RBC (lower serum level of reduced glutathione and ascorbic acid) and stimulated erythropoiesis in bone marrow (increased serum Hb and RBC count, reticulocytosis). "
6.	gamma-GlobinsIBA 03/01/1985 - "The persistence of reticulocytosis throughout the treatment with azaC or d-azaC makes it appear likely that the observed increase in Hb F levels to more than 60% of total hemoglobin is not due to a cytotoxic effect on erythropoiesis resulting in a shift of cell populations toward greater immaturity, but to a direct influence of the drug on the regulation of gamma globin chain production." 05/15/2001 - "Human gamma-globin messenger RNA (mRNA) expression at 7% of the level of total endogenous alpha-globin mRNA in thalassemic erythroid cells resulted in improved red cell morphology, a greater than 2-g/dL increase in Hb, and diminished reticulocytosis and extramedullary erythropoiesis. " 09/05/2005 - "Scriptaid induced reticulocytosis and human gamma-globin mRNA synthesis. "
7.	SodiumIBA 01/01/1990 - "Only a slight reticulocytosis was observed in these animals although their erythrocytes showed a marked decrease in their ability to extrude sodium actively. " 04/01/1981 - "Calcium and sodium permeability of erythrocytes from patients with untransfused alpha- or beta- thalassemia major has been studied and compared to mature erythrocytes or control cells with comparable reticulocytosis. " 02/01/1988 - "5. The increases in Na+,K+-ATPase in pregnancy were not closely related to the concomitant increases in aldosterone or cholesterol nor to reticulocytosis and were not affected by 7 days of high (greater than 250 mmol/day) or low (less than 50 mmol/day) sodium intake."
8.	Messenger RNA (mRNA)IBA 08/29/2013 - "Increased levels of circulating Epo lead to reticulocytosis, polycythemia, and suppression of hepatic hepcidin mRNA. " 05/15/2001 - "Human gamma-globin messenger RNA (mRNA) expression at 7% of the level of total endogenous alpha-globin mRNA in thalassemic erythroid cells resulted in improved red cell morphology, a greater than 2-g/dL increase in Hb, and diminished reticulocytosis and extramedullary erythropoiesis. " 09/05/2005 - "Scriptaid induced reticulocytosis and human gamma-globin mRNA synthesis. "
9.	Prednisone (Sone)FDA LinkGeneric 05/01/1981 - "Treatment with cyclophosphamide and prednisone induced reticulocytosis in all four CLL-PRCA patients. " 10/01/1986 - "Children with acute leukemia in remission manifest reticulocytosis and a significant increase in hemoglobin concentration (mean increment of 2.3 +/- 1.1 g/dl) following prednisone pulse therapy. " 02/01/1973 - "When the red cell aplasia was treated with cyclophosphamide and prednisone, marrow cell incorporation of (59)Fe into heme in vitro increased several weeks before a reticulocytosis was apparent, and was the earliest effect noted. "
10.	LectinsIBA 06/01/1984 - "A selective and significant reduction in the density of WGA receptors, but not other lectins was noted congruent to the degree of reticulocytosis. " 02/01/1986 - "A similar effect was indicated with erythrocytes obtained during an acute Anaplasma marginale infection; however, an ensuing reticulocytosis masked the effect, requiring the use of fluoresceinated lectins to verify that increased binding of each lectin occurred with infected cells when compared to normal cells."

Therapies and Procedures

1.	Therapeutics 03/01/2003 - "However, whereas dogs in the P group showed increases in reticulocyte count, reticulocytosis was suppressed in dogs in the PC group during the 1st week of therapy. " 01/01/1998 - "Two months after initiation of the therapy, the patient developed reticulocytosis and blood transfusion was not needed thereafter. " 08/01/2001 - "Reticulocytosis and recovery from anemia were observed on day 7 after the start of therapy. " 06/01/2001 - "During induction therapy, the MCV increased transiently because of reticulocytosis and then stabilized for a prolonged period before decreasing more sharply, which reflected iron-limited erythropoiesis. " 04/01/1997 - "Changes in adhesion receptor expression were not caused by a decrease in reticulocytosis with HU therapy. "
2.	Retreatment 10/01/1985 - "Within 4-6 months, they relapsed, and after retreatment with ATG both again developed reticulocytosis and remission. "
3.	Thymectomy 01/01/1985 - "After six weeks treatment including steroids, cyclophosphamide and three courses of plasma exchange without improvement, surgical thymectomy was followed by a reticulocytosis and remission of the red cell aplasia. "
4.	Plasmapheresis 04/01/2008 - "Immediately following plasmapheresis, the patient demonstrated clinical improvement followed by attenuation of the hemolysis and improved reticulocytosis. "
5.	Plasma Exchange 01/01/1985 - "After six weeks treatment including steroids, cyclophosphamide and three courses of plasma exchange without improvement, surgical thymectomy was followed by a reticulocytosis and remission of the red cell aplasia. "