Progesterone Congeners

Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.

Also Known As:

Progestagens, Synthetic; Progestational Hormone Analogs; Progestational Hormone Analogues; Progestational Hormones, Synthetic; Progestin Analogs; Progestin Analogues; Progestins, Synthetic; Progestogens, Synthetic; Synthetic Progestational Hormones; Synthetic Progestins; Progestin, Synthetic; Synthetic Progestagens; Synthetic Progestogens; Synthetic Progestin

Networked: 320 relevant articles (10 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Progesterone Congeners: 320
        Progesterone: 12723
        Pregnenolone: 356
        chlorpromadinone acetate: 1
        Duogestral
        selective progesterone receptor modulator EC313

Experts

1.	Hyder, Salman M: 15 articles (01/2017 - 02/2005)
2.	Liang, Yayun: 8 articles (01/2017 - 02/2005)
3.	Besch-Williford, Cynthia: 6 articles (01/2015 - 07/2006)
4.	Mueck, A O: 6 articles (10/2013 - 01/2002)
5.	Seeger, H: 6 articles (10/2013 - 01/2002)
6.	Mafuvadze, Benford: 5 articles (01/2017 - 09/2010)
7.	Benakanakere, Indira: 5 articles (08/2011 - 07/2006)
8.	Afzal, Mohammad: 5 articles (02/2008 - 11/2004)
9.	Siddique, Yasir Hasan: 5 articles (02/2008 - 11/2004)
10.	Schumacher, Michael: 4 articles (10/2021 - 08/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/1995 - "High doses of oral synthetic progestins are effective in the treatment of breast cancer.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/15/2007 - "Recent clinical trials indicate that synthetic progestins may stimulate progression of breast cancer in postmenopausal women, a result that is consistent with studies in chemically-induced breast cancer models in rodents. " 10/01/1991 - "This study documents a biphasic change in the rate of cell cycle progression and proliferation of T-47D human breast cancer cells treated with synthetic progestins, consisting of an initial transient acceleration in transit through G1, followed by cell cycle arrest and growth inhibition. " 07/01/1980 - "A study was made of basic mechanisms involved in regression of breast cancer exposed to high levels of synthetic progestins. " 01/01/2022 - "Although menopausal HT use appears to be associated with an overall increased risk of breast cancer, this risk appears predominantly mediated through formulations containing synthetic progestins. "
2.	Neoplasms (Cancer) 02/15/2002 - "This first, large scale study of PR gene regulation has important implications for the measurement of PR in breast cancers and for the many clinical uses of synthetic progestins. " 10/01/2012 - "Some synthetic progestins trigger a proliferative response of PGRMC1-overexpressed MCF-7 cancer cells. " 09/01/2010 - "Synthetic progestins differentially promote or prevent 7,12-dimethylbenz(a)anthracene-induced mammary tumors in sprague-dawley rats." 07/01/1988 - "Each synthetic "progestin" exerted a marked stimulatory effect on the growth of the tumor. " 01/01/1976 - "[Synthetic progestins in combined treatment of cancer of the uterine body]."
3.	Hyperplasia 12/01/1997 - "The good results with natural and synthetic progestins suggest that this treatment can be used both in premenopause and postmenopause hyperplasia. " 07/01/2014 - "LYN which is a synthetic progestin ensures better endometrial control compared to MP in simple hyperplasia without atypia in the patients of premenopausal age especially in ages more than 45 years." 01/01/2000 - "These studies shed new light on the mechanism of progesterone-induced mammary hyperplasia and urges for further research on potential adverse effects of synthetic progestins." 01/01/2000 - "Toxicity studies using beagle dogs revealed in the 1980s that synthetic progestins may induce a syndrome of growth hormone (GH) excess, known as acromegaly, and the development of predominantly benign mammary hyperplasia. " 03/01/2004 - "According to clinical manifestations of hyperplasia, the patients were divided into 3 groups: 74 (53%) had reestablishing menstrual function after total curettage (group 1); 42 patients (30%) with glandular-cystic hyperplasia after curettage and hormonal therapy with progesterone and synthetic progestins (duration 3 to 6 months) had no repeated pathology of the endometrium (group 2); endometrial hyperplasia recurred 2 and 3 times as showed biopsies during 2-5 years of observation in 23 (17%) women (group 3). "
4.	Ovarian Epithelial Carcinoma 06/03/2023 - "In vitro chemo-preventive efficacy of synthetic progestin Norethindrone in human epithelial ovarian cancer." 06/03/2023 - "Therefore, the aim of the present study was to evaluate the chemo-preventive potential of synthetic progestin Norethindrone (NET) in epithelial ovarian cancer in vitro. "
5.	Endometriosis 01/01/2022 - "We performed an analysis to demonstrate the molecular changes that occur in endometriosis synthetic progestin-treated patients, hoping to sketch a possible pathophysiological pathway that will help us to better understand and treat this debilitating disease. " 03/01/1985 - "[Effect of synthetic progestins on the endocervix of patients with internal uterine endometriosis]." 10/01/1980 - " An individual approach to the choice of a type and dose of synthetic progestins depending upon the patient's age, duration of the disease, type of endometriosis, and hormonal background is recommended." 05/01/1979 - "[Clinico-morphological characteristics of endometriosis of different localization during treatment with synthetic progestins]." 12/01/1977 - "[Characteristics of the reproductive function in genital endometriosis before and after the use of synthetic progestins]."

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Progesterone
3.	Medroxyprogesterone Acetate (Depo-Provera)
4.	Norethindrone (Norethisterone)
5.	Androgens
6.	Norgestrel (DL-Norgestrel)
7.	Tamoxifen
8.	dienogest
9.	Endocrine Disruptors
10.	Progestins (Progestagens)

Related Therapies and Procedures

1.	Therapeutics
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Drug Therapy (Chemotherapy)
4.	Contraception (Birth Control)
5.	Estrogen Replacement Therapy