Butyryl-CoA Dehydrogenase (Short-Chain Acyl-CoA Dehydrogenase)

A flavoprotein oxidoreductase that has specificity for short-chain fatty acids. It forms a complex with ELECTRON-TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE.

Also Known As:

Short-Chain Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Short-Chain; Butyryl Dehydrogenase; Butyryl-Coenzyme A Dehydrogenase; Butyryl CoA Dehydrogenase; Butyryl Coenzyme A Dehydrogenase; Dehydrogenase, Butyryl; Dehydrogenase, Butyryl-CoA; Dehydrogenase, Butyryl-Coenzyme A; Dehydrogenase, Short-Chain Acyl-CoA; Short Chain Acyl CoA Dehydrogenase

Networked: 77 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gregersen, Niels: 8 articles (01/2021 - 04/2003)
2.	Zhou, Sigui: 5 articles (10/2020 - 07/2015)
3.	Vockley, Jerry: 5 articles (05/2014 - 08/2003)
4.	Gregersen, N: 5 articles (09/2008 - 01/2001)
5.	Liu, Peiqing: 4 articles (01/2020 - 07/2015)
6.	Bross, Peter: 4 articles (03/2014 - 11/2003)
7.	Wajner, Moacir: 4 articles (02/2010 - 05/2003)
8.	Olsen, Rikke K J: 3 articles (01/2021 - 10/2008)
9.	Ma, Zhichao: 3 articles (10/2020 - 02/2019)
10.	Pan, Xuediao: 3 articles (10/2020 - 01/2016)

Related Diseases

1.	Cardiomegaly (Heart Hypertrophy) 09/24/2010 - "Short-chain acyl-CoA dehydrogenase (SCAD) deficient mice were found to have increased brown adipose tissue mass as well as modest cardiac hypertrophy. " 09/05/2023 - "Riboflavin ameliorates pathological cardiac hypertrophy and fibrosis through the activation of short-chain acyl-CoA dehydrogenase." 01/01/2020 - "Flavine adenine dinucleotide inhibits pathological cardiac hypertrophy and fibrosis through activating short chain acyl-CoA dehydrogenase." 07/01/2015 - "This study was designed to investigate the expression of short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid β-oxidation, during rat heart development and the difference of SCAD between pathological and physiological cardiac hypertrophy. " 01/01/2016 - "Short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid β-oxidation, plays an important role in cardiac hypertrophy. "
2.	Fibrosis (Cirrhosis) 09/05/2023 - "Riboflavin ameliorates pathological cardiac hypertrophy and fibrosis through the activation of short-chain acyl-CoA dehydrogenase." 01/01/2020 - "Flavine adenine dinucleotide inhibits pathological cardiac hypertrophy and fibrosis through activating short chain acyl-CoA dehydrogenase." 09/05/2023 - "Short-chain acyl-CoA dehydrogenase (SCAD), the rate-limiting enzyme for fatty acid β-oxidation, has a negative regulatory effect on pathological cardiac hypertrophy and fibrosis. " 01/01/2020 - "Short-chain acyl-CoA dehydrogenase (SCAD), the rate-limiting enzyme for fatty acid β-oxidation, has a negative regulatory effect on pathological cardiac hypertrophy and fibrosis. "
3.	Vascular Remodeling 10/01/2020 - "Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase."
4.	Short chain Acyl CoA dehydrogenase deficiency 01/01/1990 - "Molecular cloning and nucleotide sequence of cDNAs encoding human short chain acyl-CoA dehydrogenase and study of the molecular basis of human short chain acyl-CoA dehydrogenase deficiency." 07/01/2016 - "Short-chain acyl-CoA dehydrogenase (SCAD) catalyzes the first step in mitochondrial short-chain β-oxidation, and its deficiency is caused by mutations in the ACADS We sought to investigate the spectrum ACADS mutations and associated clinical manifestations in Korean patients with SCAD deficiency. " 06/01/2016 - "Clinical relevance of short-chain acyl-CoA dehydrogenase (SCAD) deficiency: Exploring the role of new variants including the first SCAD-disease-causing allele carrying a synonymous mutation." 03/01/2014 - "Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is a rare inherited autosomal recessive disorder with not yet well established mechanisms of disease. " 06/01/2010 - "Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency."
5.	VLCAD deficiency 09/01/2001 - "In the present review we summarize current knowledge regarding genotype-phenotype relationships in three disorders of mitochondrial fatty acid oxidation: very-long chain acyl-CoA dehydrogenase (VLCAD, also ACADVL), medium-chain acyl-CoA dehydrogenase (MCAD, also ACADM), and short-chain acyl-CoA dehydrogenase (SCAD, also ACADS) deficiencies. " 01/01/2019 - "In the current study, the regression analysis was performed to identify short chain acyl-CoA dehydrogenase (SCAD) deficiency, medium chain acyl-CoA dehydrogenase (MCAD) deficiency, and very long chain acyl-CoA dehydrogenase (VLCAD) deficiency. " 11/01/2017 - "The fatty acid oxidation defects identified were sub-grouped into: medium chain acyl CoA dehydrogenase deficiency (MCAD) = 4; very long chain acyl CoA dehydrogenase deficiency (VLCAD) = 7; MADD = 6; carnitine uptake defect and short chain acyl CoA dehydrogenase (SCAD) deficiency = 1 each. " 01/01/2018 - "Fourteen patients were diagnosed with FAODs by NBS at the age of 54.8 ± 4.8 days: 5 with very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency, 5 with medium chain acyl-CoA dehydrogenase (MCAD) deficiency, 1 with primary carnitine deficiency, 1 with carnitine palmitoyltransferase 1A (CPT1A) deficiency, 1 with long-chain 3-hydroxyacyl-CoA dehydrogenase or mitochondrial trifunctional protein (LCAHD/MTP) deficiency, and 1 with short chain acyl-CoA dehydrogenase (SCAD) deficiency. " 11/01/2001 - "We identified 22 babies with amino acid disorders (7 phenylketonuria, 11 hyperphenylalaninemia, 1 maple syrup urine disease, 1 hypermethioninemia, 1 arginosuccinate lyase deficiency, and 1 argininemia) and 20 infants with fatty and organic acid disorders (10 medium-chain acyl-CoA dehydrogenase deficiencies, 5 presumptive short-chain acyl-CoA dehydrogenase deficiencies, 2 propionic acidemias, 1 carnitine palmitoyltransferase II deficiency, 1 methylcrotonyl-CoA carboxylase deficiency, and 1 presumptive very-long chain acyl-CoA dehydrogenase deficiency). "

Related Drugs and Biologics

1.	Riboflavin (Vitamin B2)
2.	Flavin-Adenine Dinucleotide (FAD)
3.	Fatty Acids (Saturated Fatty Acids)
4.	Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)
5.	Enzymes
6.	Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)
7.	Proteins (Proteins, Gene)
8.	ethylmalonic acid (ethylmalonate)
9.	Transferases
10.	Coenzyme A (CoA)