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Glucose Metabolism Disorders

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Pathological conditions in which the BLOOD GLUCOSE cannot be maintained within the normal range, such as in HYPOGLYCEMIA and HYPERGLYCEMIA. Etiology of these disorders varies. Plasma glucose concentration is critical to survival for it is the predominant fuel for the CENTRAL NERVOUS SYSTEM.

Also Known As:

Glucose Metabolic Disorder; Glucose Metabolic Disorders; Glucose Metabolism Disorder; Disorder, Glucose Metabolic; Disorder, Glucose Metabolism; Disorders, Glucose Metabolic; Disorders, Glucose Metabolism; Metabolic Disorder, Glucose; Metabolic Disorders, Glucose; Metabolism Disorder, Glucose; Metabolism Disorders, Glucose

Networked: 91 relevant articles (10 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases: 2
- Metabolic Diseases: 3200
  - Glucose Metabolism Disorders: 91

Related Diseases

1.	Insulin Resistance
2.	Obesity
3.	Coronary Disease (Coronary Heart Disease)
4.	Hypoglycemia (Reactive Hypoglycemia)
5.	Gestational Diabetes (Gestational Diabetes Mellitus)

Experts

1.	Junik, Roman: 2 articles (01/2015 - 01/2013)
2.	Kamińska, Anna: 2 articles (01/2015 - 01/2013)
3.	Yu, Jian-Wu: 2 articles (06/2014 - 06/2013)
4.	Sun, Li-Jie: 2 articles (06/2014 - 06/2013)
5.	Li, Yi-Fang: 2 articles (10/2013 - 01/2011)
6.	Tsoi, Bun: 2 articles (10/2013 - 01/2011)
7.	Kurihara, Hiroshi: 2 articles (10/2013 - 01/2011)
8.	He, Rong-Rong: 2 articles (10/2013 - 01/2011)
9.	Yang, Hui-xia: 2 articles (08/2011 - 04/2008)
10.	Ellinghaus, Peter: 2 articles (01/2009 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Glucose Metabolism Disorders:

1.	Glucose (Dextrose)FDA LinkGeneric 06/01/2013 - "The results showed that FF16 significantly improved the glucose metabolic disorders through reducing FBG by 15.1%, decreasing AUC values in glucose tolerance tests by 22.3%. " 06/01/2014 - "CB1R antagonist improved glucose metabolism disorders by an increase in glucose uptake and a decrease in glucose production, and inhibited HCV replication. " 06/01/2013 - "SIRT1 activator improved glucose metabolism disorders by an increase in glucose uptake and a decrease in glucose production, and it inhibited HCV replication. " 01/01/2008 - "[The dual (joker) function of glucose: study of its association with aging and glucose metabolism disorders]." 03/01/2015 - "31, 2006 was defined as Group 2006, and they were diagnosed with glucose metabolism disorder [gestational impaired glucose tolerance (GIGT) and GDM] and intervened only when meeting National diabetes data group (NDDG) criteria. "
2.	Insulin (Novolin)FDA Link 09/01/2013 - "It was indicated that the therapeutic mechanisms of action of GD on type 2 DM might be related to its effect of ameliorating glucose metabolism disorders, relieving insulin resistance, increasing the tissues' sensitivity to insulin, improving the antioxidative ability of living system, GD has therapeutic effect on type 2 DM and protective effects against damaged pancreatic function." 01/01/2003 - "Insulin assays play a central role in the investigation of glucose metabolism disorders (investigation of the causes of hypoglycemia, assessment of beta-cell function and determination of pathogenesis of type 1 and type 2 diabetes), and in studies on the pharmacology of insulin itself. " 01/25/2013 - "These findings suggest that Tan IIA enhances insulin sensitivity and improves glucose metabolic disorders by increasing AMPK activity and attenuating ER stress-induced insulin resistance." 03/07/2009 - "This combined effect renders the entire body less sensitive to insulin, promoting development of atherosclerosis and glucose metabolism disorders. " 02/01/2008 - "Glucose metabolic disorders appear if overproduction of insulin can not compensate the insulin resistance. "
3.	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/01/2005 - "More powerful new compounds with pan-PPAR activity and proven long-term safety should be highly effective in a clinical setting of patients with coexisting relevant lipid and glucose metabolism disorders."
4.	TeaIBA 12/01/2004 - "Long-term feeding of tea catechins could be beneficial for the suppression of high-fat diet-induced obesity by modulating lipid metabolism, could have a beneficial effect against lipid and glucose metabolism disorders implicated in type 2 diabetes, and could also reduce the risk of coronary disease. "
5.	CarnosineIBA 01/01/2011 - "Carnosine ameliorates stress-induced glucose metabolism disorder in restrained mice."
6.	rheinIBA 11/01/2013 - "Rhein, an anthraquinone compound isolated from rhubarb, has been shown to improve glucose metabolism disorders in diabetic mice. "
7.	FHDIBA 03/01/2013 - "Postnatal stress (three maternal deprivations before weaning) did not affect the risk of developing IFG or DB in H voles, but significantly reduced the frequency of glucose metabolism disorders (IFG and DB combined) in FHD voles. "
8.	Tacrolimus (Prograf)FDA LinkGeneric 01/01/1996 - "Safety profiles were comparable for most major categories (including renal, neurological and glucose metabolic disorders) and in certain aspects were more favourable for tacrolimus. " 11/27/2001 - "Induction with an FK-506 based immunosuppressive regimen resulted in a high incidence of glucose metabolism disorders in renal transplantation recipients. " 06/01/2007 - "Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus." 01/01/2013 - "We did not find any differences in the frequency of glucose metabolism disorders between patients treated with tacrolimus and with cyclosporine. " 01/01/2013 - "The aim of this study was to assess the frequency of PTDM, IFG and IGT in a group of renal transplant recipients, to compare the frequency of glucose metabolism disorders in subjects treated with tacrolimus and with cyclosporine, and to establish the influence of different risk factors on the development of glucose metabolism disorders. "
9.	Cyclosporine (Ciclosporin)FDA LinkGeneric 06/01/2007 - "Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus." 01/01/2013 - "We did not find any differences in the frequency of glucose metabolism disorders between patients treated with tacrolimus and with cyclosporine. " 01/01/2013 - "The aim of this study was to assess the frequency of PTDM, IFG and IGT in a group of renal transplant recipients, to compare the frequency of glucose metabolism disorders in subjects treated with tacrolimus and with cyclosporine, and to establish the influence of different risk factors on the development of glucose metabolism disorders. " 03/01/2003 - "Thus, we evaluated the mechanism by which tacrolimus causes glucose metabolic disorders, risk factors for glucose metabolic disorders during tacrolimus treatment, the relative roles of corticosteroids and tacrolimus trough levels in glucose metabolic disorders, and also differences in glucose metabolism between patients using tacrolimus versus patients using cyclosporine. "
10.	Galactose (Galactopyranose)FDA LinkGeneric 01/01/2013 - "We concluded that LBP has an anti-aging effect on D-galactose induced aging model mouse, and its mechanism may be related with the alleviation of glucose metabolism disorder and the resistance of the generation of lipid peroxide and other substances, which damage cell membrane lipid. " 03/01/1990 - "[Oral galactose tolerance test in the study of glucose metabolism disorders in patients with liver disease]." 04/01/2012 - "AMI rats of CBSS was closely correlated with myocardial metabolites such as malic acid, glutamic acid, glycine, glucose, fumaric acid, urea, galactopyranose, lactic acid, alanine, and tyrosine, etc. The metabolite profile of rats' myocardial tissue showed AMI rat model of CBSS was closely correlated with post-hypoxia glucose metabolism disorder. "

Therapies and Procedures

1.	Chelation Therapy (Therapy, Chelation) 12/01/2004 - "Glucose metabolism disorders improvement in patients with thalassaemia major after 24-36 months of intensive chelation therapy."
2.	Transplantation (Transplant Recipients) 06/01/2007 - "Glucose metabolic disorder after transplantation." 11/01/2005 - "ACE D and AGT T alleles may be implicated in glucose metabolism disorders after transplantation." 04/15/2011 - "Incidence and risk factors of glucose metabolism disorders in kidney transplant recipients: role of systematic screening by oral glucose tolerance test." 01/01/2013 - "The aim of this study was to assess the frequency of PTDM, IFG and IGT in a group of renal transplant recipients, to compare the frequency of glucose metabolism disorders in subjects treated with tacrolimus and with cyclosporine, and to establish the influence of different risk factors on the development of glucose metabolism disorders. " 02/01/2007 - "Different mechanisms might explain post-transplantation glucose metabolism disorders: ischemia-reperfusion disorders, whether renal, hepatic or cardiac, are responsible for insulin-resistance, which is increased by post-transplantation steroids; the detrimental effect of non-steroid immunosuppressive drugs on insulin-secretion could also be involved, especially with calcineurin inhibitors. "
3.	Peritoneal Dialysis 04/01/2015 - "Glucose challenge test (50-g GCT) in detection of glucose metabolism disorders in peritoneal dialysis patients: preliminary study." 04/01/2015 - "The aim was to evaluate the clinical utility of the oral glucose tolerance screening test (50-g GCT--glucose challenge test) for the detection of glucose metabolism disorders (GMD) in peritoneal dialysis (PD) patients with normal fasting glucose levels. "
4.	Kidney Transplantation 01/01/2013 - "Patients with higher BMI and with first-degree relatives with diabetes had an increased risk of glucose metabolism disorders after kidney transplantation." 01/01/2013 - "Factors associated with glucose metabolism disorders after kidney transplantation." 11/01/2007 - "Risk factors for glucose metabolism disorders after kidney transplantation with uneventful course." 09/01/2012 - "LVMI does not always improve in RTR; the evolution of ventricular mass after renal transplantation is influenced by glucose metabolism disorders, oxidative stress, and graft function." 11/01/2007 - "A wide range of glucose metabolic disorders (GMDs) often arise after renal transplantation that predispose to graft dysfunction, infections, and cardiovascular disease. "
5.	Transplants (Transplant) 09/01/2008 - "PTDM has been developed in six patients (13%), while seven children (16%) had IGT, with the overall incidence of a glucose metabolic disorder of 29% in pediatric renal transplants. " 09/01/2012 - "LVMI does not always improve in RTR; the evolution of ventricular mass after renal transplantation is influenced by glucose metabolism disorders, oxidative stress, and graft function." 11/01/2007 - "A wide range of glucose metabolic disorders (GMDs) often arise after renal transplantation that predispose to graft dysfunction, infections, and cardiovascular disease. "