Neutropenic Enterocolitis

A syndrome characterized by inflammation in the ILEUM, the CECUM, and the ASCENDING COLON. It is observed in cancer patients with CHEMOTHERAPY-induced NEUTROPENIA or in other immunocompromised individuals (IMMUNOCOMPROMISED HOST).

Also Known As:

Networked: 94 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Non-Hodgkin Lymphoma (Lymphosarcoma)
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
3.	Sepsis (Septicemia)
4.	Leukemia
5.	Neoplasms (Cancer)

Experts

1.	Davila, Marta L: 3 articles (03/2007 - 01/2006)
2.	Cartoni, C: 3 articles (03/2004 - 02/2001)
3.	Rolston, Kenneth V I: 2 articles (03/2013 - 08/2009)
4.	Ziske, Carsten: 2 articles (01/2006 - 07/2005)
5.	Strehl, John: 2 articles (01/2006 - 07/2005)
6.	Schmidt-Wolf, Ingo G H: 2 articles (01/2006 - 07/2005)
7.	Glasmacher, Axel: 2 articles (01/2006 - 07/2005)
8.	Gorschlüter, Marcus: 2 articles (01/2006 - 07/2005)
9.	Mey, Ulrich: 2 articles (01/2006 - 07/2005)
10.	Mandelli, F: 2 articles (03/2004 - 02/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neutropenic Enterocolitis:

1.	Cytarabine (Cytosar-U)FDA LinkGeneric 04/01/1991 - "A retrospective clinical study was performed to determine the clinical impact of neutropenic enterocolitis (NE) in adult patients with acute leukemia and non-Hodgkin's lymphoma treated with cytosine arabinoside (Ara-C)-containing regimens. " 04/01/1991 - "Neutropenic enterocolitis following treatment with cytosine arabinoside-containing regimens for hematological malignancies: a potentiating role for amsacrine." 09/06/2012 - "Such complications, discussed herein, include tumor lysis, hyperleukocytosis, cytarabine-induced cellebellar toxicity, acute promyelocytic leukemia differentiation syndrome, thrombohemorrhagic syndrome in acute promyelocytic leukemia, L-asparaginase-associated thrombosis, leukemic meningitis, neutropenic fever, neutropenic enterocolitis, and transfussion-associated GVHD. "
2.	docetaxel (Taxotere)FDA Link 04/01/2009 - "Neutropenic enterocolitis and docetaxel neoadjuvant chemotherapy." 08/01/2009 - "Neutropenic enterocolitis associated with docetaxel therapy in a patient with breast cancer." 06/01/2004 - "Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature." 08/01/2007 - "[Poor outcome neutropenic enterocolitis after treatment with docetaxel in a breast cancer patient]." 10/15/2010 - "Apart from pseudomembranous colitis, we describe patients presenting with neutropenic enterocolitis as well as ischemic colitis after docetaxel use. "
3.	Carboplatin (JM8)FDA LinkGeneric 10/01/1990 - "This case is the first report of neutropenic enterocolitis associated with the treatment of carboplatin." 01/01/1992 - "Neutropenic enterocolitis and intestinal perforation associated with carboplatin-containing conditioning regimen for autologous bone marrow transplantation." 10/01/1990 - "She developed neutropenic enterocolitis after treatment with high-dose carboplatin (1000 mg/m2) and granulocyte macrophage-colony stimulating factor (GM-CSF). " 04/01/2011 - "Neutropenic enterocolitis during first-line chemotherapy with carboplatin and etoposide in small cell lung cancer." 10/01/1990 - "Neutropenic enterocolitis in a patient with ovarian cancer after treatment with high-dose carboplatin and granulocyte macrophage-colony stimulating factor (GM-CSF)."
4.	Fluorouracil (Carac)FDA LinkGeneric 05/01/2002 - "Neutropenic enterocolitis in a woman treated with 5-fluorouracil and leucovorin for colon carcinoma." 08/15/1997 - "This case indicates that neutropenic enterocolitis may occur in patients with colorectal carcinoma receiving 5-fluorouracil and leucovorin." 08/15/1997 - "The authors report a patient with colorectal carcinoma who developed neutropenic enterocolitis after treatment with 5-fluorouracil and leucovorin. " 08/15/1997 - "Neutropenic enterocolitis in a patient with colorectal carcinoma: unusual course after treatment with 5-fluorouracil and leucovorin--a case report." 02/01/1990 - "We present, to our knowledge, the first case of neutropenic enterocolitis in a patient receiving cisplatin and fluorouracil chemotherapy for metastatic head and neck cancer."
5.	taxaneIBA 06/01/2002 - "Reviewing the literature, neutropenic enterocolitis is uncommon but not unknown in patients treated with taxane-based chemotherapy. " 06/01/2000 - "In conclusion, acute neutropenic enterocolitis is a severe complication of taxane-based chemotherapy. " 06/01/2000 - "Five cases of acute neutropenic enterocolitis complicating taxane-based chemotherapy are described. " 06/01/2000 - "Successful conservative treatment of neutropenic enterocolitis complicating taxane-based chemotherapy: a report of five cases." 01/01/2008 - "Neutropenic enterocolitis in breast cancer patient after taxane-containing chemotherapy."
6.	Fluconazole (Zonal)FDA LinkGeneric 01/01/1999 - "Detection of Candida mannoproteinemia seems to be a useful diagnostic tool in patients with neutropenic enterocolitis and represents an additional tool for selecting a less empiric, low toxic antifungal treatment with fluconazole." 01/01/2004 - "Owing to suspicion of neutropenic enterocolitis, antibiotic therapy intensified with teicoplanin, fluconazole, metronidazole and pipril. "
7.	Ribavirin (Virazole)FDA LinkGeneric 07/01/2008 - "Neutropenic enterocolitis: An unusual complication of HCV combination therapy with PEG-IFN and ribavirin." 09/01/2009 - "Fatal Neutropenic Enterocolitis during Pegylated Interferon and Ribavirin Combination Therapy for Chronic Hepatitis C Virus Infection."
8.	Leucovorin (Folinic Acid)FDA Link 05/01/2002 - "Neutropenic enterocolitis in a woman treated with 5-fluorouracil and leucovorin for colon carcinoma." 08/15/1997 - "This case indicates that neutropenic enterocolitis may occur in patients with colorectal carcinoma receiving 5-fluorouracil and leucovorin." 08/15/1997 - "The authors report a patient with colorectal carcinoma who developed neutropenic enterocolitis after treatment with 5-fluorouracil and leucovorin. " 08/15/1997 - "Neutropenic enterocolitis in a patient with colorectal carcinoma: unusual course after treatment with 5-fluorouracil and leucovorin--a case report."
9.	Asparaginase (Elspar)FDA Link 09/06/2012 - "Such complications, discussed herein, include tumor lysis, hyperleukocytosis, cytarabine-induced cellebellar toxicity, acute promyelocytic leukemia differentiation syndrome, thrombohemorrhagic syndrome in acute promyelocytic leukemia, L-asparaginase-associated thrombosis, leukemic meningitis, neutropenic fever, neutropenic enterocolitis, and transfussion-associated GVHD. " 10/01/2004 - "This is a case report of neutropenic enterocolitis in a patient with acute lymphoblast leukemia who received prednisone, vincristine, daunorubicin and L-asparaginase, with perforation of cecal and terminal ileum. "
10.	Anti-Bacterial Agents (Antibiotics)IBA 02/01/2012 - "She received antibiotics for 21 days for neutropenic enterocolitis. " 10/01/1987 - "All seven patients responded to intensive medical therapy, including bowel rest, broad spectrum antibiotics, and white blood cell transfusions, and recovered from the neutropenic enterocolitis without surgical intervention. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2015 - "Neutropenic enterocolitis (NE) is a deadly ileocecal-based disease seen in patients with a recent history of chemotherapy. " 01/26/2015 - "Neutropenic enterocolitis (NE) is a possible life-threatening complication to chemotherapy. " 01/01/2014 - "Neutropenic enterocolitis affecting the transverse colon: an unusual complication of chemotherapy." 03/01/2013 - "Neutropenic enterocolitis, a growing concern in the era of widespread use of aggressive chemotherapy." 04/01/2012 - "Neutropenic enterocolitis is a common gastrointestinal complication in children undergoing chemotherapy for a variety of malignancies. "
2.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 04/01/2014 - "Here we report a case of a 59-year-old man who developed neutropenic enterocolitis(NE)after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma in his second complete remission.Four" 04/01/2014 - "[Neutropenic enterocolitis after autologous peripheral blood stem cell transplantation in non-Hodgkin's lymphoma - a case report]." 10/01/1998 - "[A case of neutropenic enterocolitis in high dose chemotherapy with peripheral blood stem cell transplantation for relapsed testicular tumor]."
3.	Transplantation (Transplant Recipients) 11/10/2007 - "[Neutropenic enterocolitis in adult patients with acute leukemia or stem cell transplant recipients: study of 7 cases]."
4.	Transplants (Transplant) 09/01/2003 - "Neutropenic enterocolitis in a renal transplant patient. " 11/01/1991 - "Neutropenic enterocolitis in a renal transplant patient." 09/01/2008 - "Typhilitis or neutropenic enterocolitis is a potentially life-threatening complication of cancer treatment often found in immunocompromised children receiving vigorous chemotherapeutic regimens and noted in children post-stem-cell transplant. " 05/01/2002 - "Neutropenic enterocolitis (typhlitis) after pediatric bone marrow transplant."
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/01/1992 - "Neutropenic enterocolitis associated with autologous bone marrow transplantation." 05/01/2002 - "Neutropenic enterocolitis (typhlitis) is a common consideration after bone marrow transplantation. " 10/01/2001 - "We describe the case of a young woman who, during the neutropenic phase following autologous bone marrow transplantation for relapsed acute myeloid leukemia, developed neutropenic enterocolitis complicated by an acute pseudo-obstruction of descendent colon and sigma. " 05/01/1992 - "Fatal neutropenic enterocolitis was seen in a patient undergoing autologous bone marrow transplantation for non-Hodgkin's lymphoma. " 01/01/1992 - "Neutropenic enterocolitis and intestinal perforation associated with carboplatin-containing conditioning regimen for autologous bone marrow transplantation."