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PAR-2 Receptor

A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
Also Known As:
Receptor, PAR-2; PAR2 Receptor; Protease-Activated Receptor 2; Receptor, Trypsin; Trypsin Receptor; Trypsin Receptors; PAR 2 Receptor; Protease Activated Receptor 2; Receptor 2, Protease-Activated; Receptor, PAR 2; Receptor, PAR2; Receptors, Trypsin; Proteinase Activated Receptor 2
Networked: 382 relevant articles (5 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hollenberg, Morley D: 16 articles (01/2022 - 11/2003)
2. Bunnett, Nigel W: 13 articles (01/2022 - 02/2002)
3. Ruf, Wolfram: 11 articles (01/2019 - 09/2006)
4. Fairlie, David P: 10 articles (01/2021 - 10/2007)
5. McGuire, John J: 10 articles (01/2021 - 01/2004)
6. Vergnolle, Nathalie: 9 articles (12/2017 - 04/2002)
7. Kagota, Satomi: 7 articles (01/2021 - 10/2014)
8. Spek, C Arnold: 7 articles (11/2018 - 03/2010)
9. Amadesi, Silvia: 7 articles (02/2013 - 11/2002)
10. Ma, Yiming: 6 articles (10/2021 - 01/2013)

Related Diseases

1. Inflammation (Inflammations)
2. Osteoarthritis
3. Acute Kidney Injury (Acute Renal Failure)
4. Pseudomonas Infections
5. Colonic Neoplasms (Colon Cancer)

Related Drugs and Biologics

1. Peptides (Polypeptides)
2. Fibrin
3. Endotoxins
4. PAR-1 Receptor
5. AZ3451
6. Tryptases (Tryptase)
7. Thromboplastin (Tissue Factor)
8. Factor VII (Proconvertin)
9. G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
10. Trypsin

Related Therapies and Procedures

1. Therapeutics
2. Renal Dialysis (Hemodialysis)
3. Ligation
4. Electroacupuncture
5. Subcutaneous Injections