PAR-2 Receptor

A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.

Also Known As:

Networked: 214 relevant articles (3 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ruf, Wolfram: 14 articles (02/2015 - 09/2006)
2.	Bunnett, Nigel W: 12 articles (10/2013 - 02/2002)
3.	Hollenberg, Morley D: 11 articles (07/2012 - 11/2003)
4.	Vergnolle, Nathalie: 9 articles (06/2012 - 04/2002)
5.	Amadesi, Silvia: 7 articles (02/2013 - 11/2002)
6.	Hou, Wei: 6 articles (09/2015 - 01/2014)
7.	Bao, Yanju: 6 articles (09/2015 - 01/2014)
8.	Hua, Baojin: 6 articles (09/2015 - 01/2014)
9.	Grady, Eileen F: 6 articles (06/2011 - 05/2004)
10.	Spek, C Arnold: 5 articles (05/2015 - 03/2010)

Related Diseases

1.	Inflammation 01/01/2010 - "The present study was undertaken to study the role of PAR-2 receptor activation in pathophysiology of intestinal inflammation. " 08/01/2015 - "Protease-activated receptor 2 (PAR-2) participates in various biological activities, including the regulation of epidermal barrier homeostasis, inflammation, pain perception, and melanosome transfer in the skin. " 09/01/2014 - "Proteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. " 09/01/2014 - "Soluble DPP4 induces inflammation and proliferation of human smooth muscle cells via protease-activated receptor 2." 01/01/2014 - "Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2."
2.	Acute Kidney Injury (Acute Renal Failure) 03/01/2010 - "Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure." 12/01/2009 - "Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure."
3.	Osteoarthritis 11/01/2010 - "This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential therapeutic target in osteoarthritis. " 11/01/2010 - "Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis." 06/01/2010 - "Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2." 12/01/2014 - "Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms."
4.	Colonic Neoplasms (Colon Cancer) 10/01/2011 - "Our previous study has demonstrated that TF/FVIIa and protease-activated receptor 2 (PAR2) are closely related to the proliferation and migration of colon cancer cell line SW620. " 11/01/2011 - "These results demonstrate, for the first time, the aberrant expression of KLK14 in colon cancer and its involvement in PAR-2 receptor signaling. " 04/01/2013 - "Our previous study has demonstrated that protease-activated receptor 2 (PAR2) activation mediated by tissue factor (TF)/VIIa complex triggers the ERK1/2/NF-κB signaling pathway, which further contributes to the proliferation and migration of colon cancer cell line SW620. " 03/01/2010 - "Our recent studies have implicated PAR1 and PAR4 (thrombin receptors) and PAR2 (trypsin receptor) in human colon cancer growth. " 11/01/2011 - "Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells."
5.	Pain (Aches) 05/01/2015 - "Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state." 01/01/2014 - "Protease-activated receptor 2 signalling pathways: a role in pain processing." 03/01/2011 - "Proteinase-activated receptor 2 was involved in the pain generation in rats with CP." 03/01/2011 - "Proteinase-activated receptor 2 (PAR2) plays a pronociceptive role in visceral pain. " 11/20/2010 - "The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice."

Related Drugs and Biologics

1.	Fibrin
2.	PAR-1 Receptor
3.	Tryptases (Tryptase)
4.	Thromboplastin (Tissue Factor)
5.	GTP-Binding Proteins (G-Protein)
6.	Trypsin
7.	Factor VIIa (Activated Factor VII)
8.	Protein Kinases (Protein Kinase)
9.	Morphine (MS Contin)
10.	Factor VII (Proconvertin)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Ligation
3.	Injections
4.	Oral Administration