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Proteinase-Activated Receptors

Subscribe to New Research on Proteinase-Activated Receptors

A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain cryptic ligands that are exposed upon the selective proteolysis of specific N-terminal cleavage sites.

Also Known As:

Receptors, Proteinase-Activated; Endopeptidase-Activated Receptors; Protease-Activated Receptors; Endopeptidase Activated Receptors; Protease Activated Receptors; Proteinase Activated Receptors; Receptors, Endopeptidase-Activated; Receptors, Protease-Activated; Receptors, Proteinase Activated

Networked: 279 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Proteinase-Activated Receptors: 279
        Thrombin Receptors: 257
        PAR-2 Receptor: 214
        mouse protease-activated receptor 3
        mouse protease-activated receptor 4

Experts

1.	Hollenberg, Morley D: 19 articles (11/2013 - 08/2002)
2.	Vergnolle, Nathalie: 11 articles (01/2013 - 10/2003)
3.	Ruf, Wolfram: 8 articles (11/2013 - 05/2004)
4.	Mackman, Nigel: 7 articles (05/2014 - 02/2004)
5.	Pawlinski, Rafal: 6 articles (11/2014 - 02/2004)
6.	Gando, Satoshi: 6 articles (05/2014 - 11/2004)
7.	Andrade-Gordon, Patricia: 6 articles (09/2008 - 03/2003)
8.	Antoniak, Silvio: 5 articles (11/2014 - 06/2011)
9.	Jesmin, Subrina: 5 articles (05/2014 - 11/2004)
10.	Oikonomopoulou, Katerina: 5 articles (10/2013 - 06/2008)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2015 - "Our findings will be helpful in further investigations into the functions and molecular mechanisms of Proteinase-activated receptors (PARs) and Trefoil factor factors (TFFs) during the progression of colorectal cancer. "
2.	Inflammation 12/01/2014 - "Many early studies described the roles of protease-activated receptors in the cellular events that occur during blood coagulation and inflammation. " 12/01/2006 - "The objective of the present study was to investigate the pattern of protease- activated receptors (PARs) over time in a model of acute liver injury induced by lipopolysaccharide (LPS); and whether PARs play a role in this process and exert their effects through inflammation and coagulation. " 11/01/2014 - "The activation of proteinase-activated receptors (PARs) has been implicated in the development of important hallmarks of inflammation, including in vivo leukocyte recruitment; however, its role in the regulation of leukocyte migration in response to inflammatory stimuli has not been elucidated until now. " 05/02/2014 - "Protease-activated receptors (PARs) are shown to play an important role in the interplay between inflammation and coagulation. " 01/01/2014 - "Evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation."
3.	Neoplasms (Cancer) 01/01/2014 - "Finally, we identified protease-activated receptors (PARs) as molecules being able to override the inverse Hippo/Hh regulation, potentially giving tumors a mechanism to utilize both oncogenic pathways in parallel.Oncogenesis" 01/01/2013 - "The role of protease-activated receptors (PARs) in lung tumors is controversial. " 01/01/2012 - "Proteinase-activated receptors (PARs) and calcium signaling in cancer." 03/01/2009 - "There are striking similarities between tumor cell invasion and cytotrophoblast implantation to the deciduas whereby the role of Protease Activated Receptors (PARs) and wnt signaling is well recognized. " 12/01/2008 - "The purpose of this investigation was to ascertain the role of protease-activated receptors (PARs) in terms of normal and tumor cell motility. "
4.	Thrombosis (Thrombus) 10/26/2010 - "Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis." 08/01/2005 - "Protease-activated receptors in hemostasis, thrombosis and vascular biology." 08/01/2002 - "proteinase-activated receptors (PARs), are expressed in endothelial cells (ECs) and neutrophils and directly affect platelet function and thrombosis. " 08/01/2012 - "Thrombin activates platelets via proteinase-activated receptors (PARs), and PAR antagonists are being evaluated in clinical trials for prevention of arterial thrombosis. " 05/01/2014 - "Growing evidence demonstrates that coagulation proteases not only regulate hemostasis and thrombosis but also contribute to the many cellular responses via activation of protease activated receptors (PARs). "
5.	Neoplasm Metastasis (Metastasis) 12/01/2014 - "More recently, studies have begun to focus on the roles of protease-activated receptors in the establishment, progression and metastasis of a variety of tumours. " 12/01/2015 - "Protease-activated receptors (PARs)-biology and role in cancer invasion and metastasis." 02/15/2006 - "Aberrant expression of protease-activated receptors (PARs) has been associated with increased angiogenesis, tumor growth, and metastasis of various cancers. " 07/01/2004 - "Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis." 01/01/2012 - "Proteinase activated receptors (PARs), a small subfamily of G protein-coupled receptors with four members, PAR₁, PAR₂, PAR₃ and PAR₄, are expressed in various tumours from epithelial origin and can play an important role in tumour progression and metastasis. "

Related Drugs and Biologics

1.	trefoil factor
2.	Thrombin
3.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
4.	Thromboplastin (Tissue Factor)
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)
6.	Chemokine Receptors
7.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
8.	Peptide Hydrolases (Proteases)
9.	Serine Proteases (Serine Protease)
10.	Fibrin