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5-HT2C Serotonin Receptor

Subscribe to New Research on 5-HT2C Serotonin Receptor

A serotonin receptor subtype found primarily in the CENTRAL NERVOUS SYSTEM and the CHOROID PLEXUS. This receptor subtype is believed to mediate the anorectic action of SEROTONIN, while selective antagonists of the 5-HT2C receptor appear to induce ANXIETY. Several isoforms of this receptor subtype exist, due to adenine deaminase editing of the receptor mRNA.

Also Known As:

Receptor, Serotonin, 5-HT2C; 5-HT(2C) Receptor; 5-HT2C Receptor; 5-Hydroxytryptamine Type 2C Receptor; 5-Hydroxytryptamine Type 2C Receptors; Receptor, 5-Hydroxytryptamine Type 2C; 2C Receptor, Serotonin; 5 HT2C Receptor; 5 Hydroxytryptamine Type 2C Receptor; 5 Hydroxytryptamine Type 2C Receptors; Receptor, 5 Hydroxytryptamine Type 2C; Receptor, 5-HT2C; Receptor, Serotonin 2C; Serotonin 2C Receptor

Networked: 237 relevant articles (13 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753

Experts

1.	Reynolds, Gavin P: 14 articles (08/2012 - 06/2002)
2.	Higgins, Guy A: 7 articles (02/2016 - 11/2003)
3.	Fletcher, Paul J: 7 articles (02/2016 - 11/2003)
4.	Langhans, Wolfgang: 5 articles (01/2010 - 01/2003)
5.	Heisler, Lora K: 4 articles (06/2014 - 11/2007)
6.	Nakai, Kunihiro: 4 articles (01/2013 - 02/2008)
7.	Nakae, Aya: 4 articles (01/2013 - 02/2008)
8.	Nonogaki, Katsunori: 4 articles (01/2012 - 07/2002)
9.	Tecott, Laurence H: 4 articles (01/2010 - 07/2002)
10.	Thomsen, William J: 4 articles (05/2008 - 03/2005)

Related Diseases

1.	Obesity 10/01/2000 - "The 5-HT2C receptor may prove to be a useful target in the development of clinically effective drugs for the treatment of obesity." 01/01/2012 - "5-HT2C receptor antagonists are thought to contribute toward increased appetite and obesity. " 01/01/2012 - "This suggests that a dynamic regulation exists of the appetite-suppressing effects of the 5-HT(2C) receptor in both the hypothalamus and the hippocampus in the ob/ob mice model of obesity. " 01/01/2012 - "Dynamic 5-HT2C receptor editing in a mouse model of obesity." 01/01/2012 - "Agonists of the 5-HT(2C) receptor have attracted much attention as therapeutic agents for the treatment of obesity. "
2.	Weight Loss (Weight Reduction) 09/01/2015 - "Weight Loss After RYGB Is Independent of and Complementary to Serotonin 2C Receptor Signaling in Male Mice." 06/01/2002 - "Association between a polymorphism of the 5-HT2C receptor and weight loss in teenage girls." 04/01/2004 - "A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes." 07/01/2000 - "In light of the sustained drug effect on body weight, the data suggest that weight loss by 5-HT(2C) receptor stimulation may be only partly dependent on changes in food consumption and that 5-HT(2C) receptor agonists may have effects on thermogenesis. " 01/01/2003 - "Indirect evidence stems from recent observations that the clinically effective anorectic agent d-fenfluramine exerts its hypophagic and weight-loss effects via 5-HT(2C) receptor activation. "
3.	Body Weight (Weight, Body) 07/01/2013 - "Small molecule activation of the 5-HT2C receptor has been shown to affect food intake and regulate body weight gain in rodent models and more recently in human clinical trials. " 01/01/2003 - "Furthermore, recent studies have also shown that 5-HT(2C) receptor agonists not only reduce feeding when acutely administered to rats or mice, they can also reduce body weight without inducing tolerance when administered chronically to obese animals. " 02/01/2010 - "Agonists of the 5-HT(2C) receptor have been shown to suppress appetite and reduce body weight in animal models as well as in humans. " 07/01/2003 - "To test this, we examined the effect of two intensities of repeated stress on food intake and body weight in 5-HT(2C) receptor KO and wild-type (WT) mice. " 05/01/2003 - "To assess whether chronic administration of the preferential 5-HT(2C) receptor agonist, mCPP, reduces rat body weight gain and to determine if this effect is wholly or partially attributable to the effect of the drug on daily food intake. "
4.	Schizophrenia (Dementia Praecox) 02/01/2011 - "The objective of this study was to determine the association of 5-HT2C (serotonin 2C receptor) and MDR1 (multidrug resistant protein) genetic polymorphisms and antipsychotic-induced metabolic abnormalities among female patients with DSM IV schizophrenia spectrum disorders. " 03/01/2005 - "Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response." 12/01/2003 - "RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia." 07/01/2001 - "RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia." 01/01/1997 - "Genetically determined variation in the 5-HT2C receptor may influence the clinical course and phenotypic expression of schizophrenia."
5.	Migraine Disorders (Migraine) 06/01/2004 - "The goal of this study is to clarify the association between migraine and Serotonin 2C receptor Cys23Ser polymorphism in Japanese population. " 02/01/2003 - "An investigation of the 5-HT2C receptor gene as a migraine candidate gene." 01/01/1997 - "In humans, a bolus dose of mCPP can cause alcohol craving (in abstinent alcoholics) and migraine (in susceptible persons), suggesting that there is a 5-HT2C receptor hyperresponsiveness in these conditions also. " 05/01/1996 - "Correlation of the receptor affinities with the potencies used in migraine prophylaxis showed significant correlations, which were better for the 5-HT2B (P = 0.001) than for the 5-HT2C receptor (P = 0.005). " 04/01/1996 - "The coding region of the 5-HT2A and 5-HT2C receptor genes was also analyzed in migraine patients and unaffected controls using polmerase chain reaction and direct sequencing. "

Related Drugs and Biologics

1.	S 20098 (agomelatine)
2.	Serotonin (5 Hydroxytryptamine)
3.	8- chloro- 2,3,4,5- tetrahydro- 1- methyl- 1H- 3- benzazepine
4.	Fenfluramine
5.	MT2 Melatonin Receptor
6.	Glucose (Dextrose)
7.	Fluoxetine (Prozac)
8.	Pro-Opiomelanocortin (Proopiomelanocortin)
9.	Fluvoxamine (Luvox)
10.	YM348

Related Therapies and Procedures

1.	Subcutaneous Infusions
2.	Injections
3.	Drug Therapy (Chemotherapy)