GTP-Binding Protein gamma Subunits

Heterotrimeric GTP-binding protein subunits that tightly associate with GTP-BINDING PROTEIN BETA SUBUNITS. A dimer of beta and gamma subunits is formed when the GTP-BINDING PROTEIN ALPHA SUBUNIT dissociates from the GTP-binding protein heterotrimeric complex. The beta-gamma dimer can play an important role in signal transduction by interacting with a variety of second messengers.

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Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Akino, T: 1 article (01/2000)
2.	Hashimoto, H: 1 article (01/2000)
3.	Ishii, S: 1 article (01/2000)
4.	Nagao, M: 1 article (01/2000)
5.	Sohma, H: 1 article (01/2000)

Related Diseases

1.	Osteoarthritis 01/01/2000 - "On the other hand, the carboxyl methylation activity on G-protein gamma-subunit in the rheumatoid synovial tissue was enhanced compared with that in the osteoarthritis synovial tissues: Km and Vm values were 2.6 microM and 10 pmol/mg x min, respectively, for the rheumatoid arthritis, and 4.8 microM and 5.6 pmol/mg x min, respectively, for the osteoarthritis. "
2.	Neoplasms (Cancer) 05/08/1998 - "859 bp of cDNA was cloned and sequenced, and the inferred amino acid sequence was found to encode a G protein gamma subunit with 98% homology to cow G protein gamma 7 and complete homology to human G protein gamma 7. The decreased expression of the G protein gamma 7 was confirmed by Northern blot assay in twelve pancreatic malignancies which included nine duct cell carcinomas, two cystoadenocarcinomas and one blastoma. "
3.	Carcinoma (Carcinomatosis) 05/08/1998 - "859 bp of cDNA was cloned and sequenced, and the inferred amino acid sequence was found to encode a G protein gamma subunit with 98% homology to cow G protein gamma 7 and complete homology to human G protein gamma 7. The decreased expression of the G protein gamma 7 was confirmed by Northern blot assay in twelve pancreatic malignancies which included nine duct cell carcinomas, two cystoadenocarcinomas and one blastoma. "
4.	Rheumatoid Arthritis 01/01/2000 - "Elevation of carboxyl methylation activity on GTP-binding protein gamma-subunit in synovial tissues from rheumatoid arthritis: how does elevation of the methylation relate to the signal transduction system of rheumatoid arthritis?" 01/01/2000 - "On the other hand, the carboxyl methylation activity on G-protein gamma-subunit in the rheumatoid synovial tissue was enhanced compared with that in the osteoarthritis synovial tissues: Km and Vm values were 2.6 microM and 10 pmol/mg x min, respectively, for the rheumatoid arthritis, and 4.8 microM and 5.6 pmol/mg x min, respectively, for the osteoarthritis. "

Related Drugs and Biologics

1.	GTP-Binding Proteins (G-Protein)
2.	Complementary DNA (cDNA)