5-HT1 Serotonin Receptors

A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.
Also Known As:
Receptors, Serotonin, 5-HT1; 5-HT1 Receptor; 5-HT1 Receptors; Serotonin 5-HT1 Receptors; Serotonin, 5-HT1 Receptors; 5 HT1 Receptor; 5 HT1 Receptors; 5-HT1 Receptor, Serotonin; 5-HT1 Receptors Serotonin; 5-HT1 Receptors, Serotonin; Receptor, 5-HT1; Receptor, Serotonin 5-HT1; Receptors Serotonin, 5-HT1; Receptors, 5-HT1; Receptors, 5-HT1 Serotonin; Receptors, Serotonin 5-HT1; Serotonin 5 HT1 Receptor; Serotonin 5 HT1 Receptors; Serotonin Receptors, 5 HT1; Serotonin, 5 HT1 Receptors; Serotonin 5-HT1 Receptor; Serotonin Receptors, 5-HT1
Networked: 71 relevant articles (13 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Tronci, E: 1 article (10/2015)
2. Fidalgo, C: 1 article (10/2015)
3. Carta, M: 1 article (10/2015)
4. Wang, Hsing-Won: 1 article (10/2015)
5. Cheng, Li-Hsiang: 1 article (10/2015)
6. Stancampiano, R: 1 article (10/2015)
7. Chiu, Feng-Shiang: 1 article (10/2015)
8. Wu, Pei-Chuan: 1 article (10/2015)
9. Liu, Shao-Cheng: 1 article (10/2015)
10. Chu, Yueng-Hsiang: 1 article (10/2015)

Related Diseases

1. Migraine Disorders (Migraine)
2. Headache (Headaches)
01/01/2002 - "Because there was only a minor transient amelioration of high altitude headache with sumatriptan, we conclude that 5-HT1 receptors do not play a major role in the pathophysiology of high altitude headache."
03/01/1992 - "Drugs used to treat headache frequently interact with serotonin receptor subtypes: abortive drugs at the 5-HT1 receptor and preventive drugs at the 5-HT2 receptor."
12/01/2000 - "In recent years, the role of serotonin (5-HT) in headache pharmacology has been unravelled in the context of both understanding its role in the nociceptive systems related to headache and by exploiting its 5-HT1 receptor subtypes in headache therapeutics. "
01/01/2002 - "Therefore, we hypothesized that sumatriptan, a 5-HT1 receptor agonist specifically effective for treatment of migraine, would also alleviate high altitude headache. "
01/01/1992 - "The evidence for this is: 5-HT concentrations in blood increase during the prodromal (aura) phase and subsequently, decrease to subnormal levels in the headache phase; migraine attacks may be triggered, in susceptible, subjects, by reserpine which depletes body serotonin; migraine attacks may be triggered, in susceptible subjects, by reserpine which depletes body serotonin; migraine attacks may be relieved by intravenous injection of 5-HT; medications known to affect 5-HT concentrations have been shown to be efficacious in both aborting (agonists of 5-HT1 receptors) and preventing (antagonists of 5-HT2 receptors) migraine attacks. "
3. Pain (Aches)
4. Epilepsy (Aura)
5. Dyskinesias (Dyskinesia)

Related Drugs and Biologics

1. Sumatriptan (Imigran)
2. Dihydroergotamine (Agit)
3. Serotonin (5 Hydroxytryptamine)
4. Tryptamines (Triptans)
5. Neurotransmitter Agents (Neurotransmitter)
6. Reserpine (Serpasil)
7. Levodopa (L Dopa)
8. Pindolol (LB 46)
9. Ketanserin
10. 5-HT3 Serotonin Receptors (5 HT3 Receptor)

Related Therapies and Procedures

1. Intravenous Injections
2. Therapeutics
3. Subcutaneous Injections
4. Spinal Injections
5. Injections