Trans Fatty Acids

UNSATURATED FATTY ACIDS that contain at least one double bond in the trans configuration, which results in a greater bond angle than the cis configuration. This results in a more extended fatty acid chain similar to SATURATED FATTY ACIDS, with closer packing and reduced fluidity. HYDROGENATION of unsaturated fatty acids increases the trans content.

Also Known As:

Networked: 360 relevant articles (3 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mozaffarian, Dariush: 17 articles (09/2015 - 04/2004)
2.	King, Irena B: 11 articles (06/2015 - 02/2002)
3.	Lemaitre, Rozenn N: 7 articles (06/2015 - 02/2002)
4.	Willett, Walter C: 7 articles (01/2008 - 04/2004)
5.	Siscovick, David S: 6 articles (06/2015 - 02/2002)
6.	Katan, M B: 6 articles (05/2013 - 06/2000)
7.	Stender, Steen: 6 articles (10/2011 - 01/2004)
8.	Dyerberg, Jørn: 6 articles (03/2008 - 01/2004)
9.	Astrup, Arne: 5 articles (01/2013 - 05/2006)
10.	Lamarche, Benoît: 5 articles (02/2012 - 11/2003)

Related Diseases

1.	Cardiovascular Diseases (Cardiovascular Disease) 08/01/2014 - "Plasma phospholipid trans-fatty acids levels, cardiovascular diseases, and total mortality: the cardiovascular health study." 05/01/2013 - "Observational studies do not show higher risks of cardiovascular disease with higher intakes of ruminant trans fatty acids. " 01/01/2011 - "Intake of industrially produced trans fatty acids (TFAs) is, according to observational studies, associated with an increased risk of cardiovascular disease, but the causal mechanisms have not been fully elucidated. " 01/01/2015 - "Trans fatty acids (TFA) are considered risk factors for cardiovascular disease (CVD), while the details of distribution and metabolism of the individual isomers are not clear. " 08/01/2014 - "Dietary trans fatty acids and cardiovascular disease risk: past and present."
2.	Atherosclerosis 04/01/2015 - "Artificial trans fatty acids promote atherosclerosis by blocking macrophage clearance of cell debris. " 12/01/2005 - "The present studies suggest that trans fatty acids may play a role in damaging and death of vascular endothelial cells in atherosclerosis." 12/01/2009 - "Trans-fatty acids in the diet stimulate atherosclerosis." 01/01/2003 - "Higher content of 18:1 trans fatty acids in subcutaneous fat of persons with coronarographically documented atherosclerosis of the coronary arteries." 10/01/1998 - "Although comparative studies of the cholesterolemic properties of trans fatty acids relative to cis-unsaturates and saturates have been conducted in humans and animals, there is no recent information relating these lipid responses to susceptibility to atherosclerosis. "
3.	Type 2 Diabetes Mellitus (MODY) 07/01/2011 - "Intake of industrially produced trans-fatty acids (TFA) has been linked to increased risk of type 2 diabetes mellitus in observational studies. " 06/01/2015 - "To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. " 09/20/1997 - "Omega-6/omega-3 fatty acid ratio and trans fatty acids in non-insulin-dependent diabetes mellitus." 05/01/1997 - "In the presence of unchanged glycemia, both dietary trans fatty acids and SFAs induce an increase in postprandial insulinemia in obese patients with NIDDM." 10/01/2009 - "We identified significant knowledge deficits in the pretest: 45% of attendees would initially recommend lifestyle changes alone, rather than statin therapy, for women diagnosed with coronary artery disease (CAD); 38% identified statin therapy as less effective in women compared with men for preventing CAD events; 27% identified Asian American women at low risk (rather than high risk) for type 2 diabetes mellitus (DM); and 21% identified processed meat (rather than baked goods) as the principal dietary source of trans fatty acids. "
4.	Coronary Artery Disease (Coronary Atherosclerosis) 01/01/2015 - "Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. " 08/01/2011 - "Trans-fatty acids in New Zealand patients with coronary artery disease." 04/01/2010 - "The overall consumption of trans fatty acids (TFAs) increases the risk of coronary artery disease. " 03/01/2008 - "In addition, fast food from major chains in most countries still contains unacceptably high levels of industrially produced trans fatty acids that have powerful biological effects, and contribute to type 2 diabetes and coronary artery disease. " 01/01/2008 - "Dietary isomeric trans fatty acids (TFAs) are suspected of increasing the risk of coronary artery disease (CAD). "
5.	Coronary Disease (Coronary Heart Disease) 03/18/2014 - "In observational studies, relative risks for coronary disease were 1.02 (95% CI, 0.97 to 1.07) for saturated, 0.99 (CI, 0.89 to 1.09) for monounsaturated, 0.93 (CI, 0.84 to 1.02) for long-chain ω-3 polyunsaturated, 1.01 (CI, 0.96 to 1.07) for ω-6 polyunsaturated, and 1.16 (CI, 1.06 to 1.27) for trans fatty acids when the top and bottom thirds of baseline dietary fatty acid intake were compared. " 07/01/2011 - "The aim of this systematic review and meta-analysis was to summarize the evidence from observational studies assessing the association between intake of trans fatty acids (TFA) and the risk of coronary heart disease (CHD), with a specific emphasis on distinguishing between TFA of industrial and ruminant origin. " 02/01/2008 - "Studies have shown a positive association between trans fatty acids (TFA) intake and risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA. " 08/01/1998 - "Despite a lack of accurate data regarding dietary intake of trans fatty acids, existing epidemiologic data and evidence from experimental feeding studies support the idea that lowering current intakes of trans fatty acids may lower the risk of coronary heart disease." 08/01/1998 - "Results from human feeding studies and recent large-scale epidemiologic surveys suggest that dietary trans fatty acids enhance the risk of developing coronary heart diseases. "

Related Drugs and Biologics

1.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
2.	Lipoproteins (Lipoprotein)
3.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
4.	Fatty Acids (Saturated Fatty Acids)
5.	Lipids
6.	Linoleic Acid (Linoleate)
7.	Margarine
8.	Vitamin A (Retinol)
9.	Cholesterol
10.	Fats

Related Therapies and Procedures

1.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)