MT1 Melatonin Receptor

09/01/2020 - "Results from protease array showed that ADAMTS1 is modulated by melatonin through mechanisms independent of the MT1 receptor in mRCC cells, and overexpression of ADAMTS1 relieved the invasion/clonogenicity and growth/metastasis inhibition imposed by melatonin treatment in vitro and in an orthotopic xenograft model. "
12/01/2009 - "Melatonin, via activation of its MT1 receptor, suppresses the development and growth of breast cancer by regulation of growth factors, regulation of gene expression, regulation of clock genes, inhibition of tumor cell invasion and metastasis, and even regulation of mammary gland development. "

11/01/2010 - "[The expression of melatonin MT1 receptor in acute necrotizing pancreatitis rats and the protective effects of melatonin]."
11/01/2010 - "To investigate the expression of melatonin MT1 receptor in rats with acute necrotizing pancreatitis (ANP) and the protective effects of melatonin (MT) pre-intervention for the pancreas. "

01/01/2018 - "The aim of this study was to evaluate the expression of MT1 receptor and GLUT1 in breast tumors and correlate with molecular subtypes and prognostic characteristics. "
02/01/2013 - "A review of the literature supports the view that MLT, via its MT1 receptor, can suppress all phases of breast cancer including initiation, promotion, and progression. "
02/01/2013 - "Our aim was to investigate the presence or absence of the MT1 melatonin receptor in the aggressive triple negative group of human breast carcinoma (TNBC) and its possible relationship to the course of the disease. "
11/01/2009 - "Alteration of the MT1 melatonin receptor gene and its expression in primary human breast tumors and breast cancer cell lines."
05/28/2002 - "Involvement of the mt1 melatonin receptor in human breast cancer."

04/01/2013 - "Hence, we propose Warthin's tumor as a useful positive control in immunohistochemical studies of MT1 melatonin receptor."
04/01/2013 - "We contribute the first immunohistochemical study of MT1 melatonin receptor in Warthin's tumor and normal parotid gland. "
02/01/2013 - "We designed this study to establish whether a truly inverse relationship exists between tissue-isolated mammary tumor growth in young (2 months), adult (12 months), and old (20 months) female Buffalo rats and the decrease in both MLT and the MT1 receptor with age, such that a causal link could be found. "
05/01/2011 - "In this study, we sought to determine whether the growth of tissue-isolated mammary tumors in young, adult, and old female Buffalo rats relates to the age-related changes in MLT and its MT1 receptor. "
01/01/2018 - "Our results have shown interestingly high expression for MT1 receptor in cancer and marginal cancer groups comparing with normal group. "

01/01/2001 - "The effects of melatonin on prostate cancer cell proliferation and their association with mt1 receptor expression were investigated in athymic nude mice xenograft models of LNCaP and PC-3 cells. "
04/01/2022 - "Our study investigations reveal that melatonin concentration-dependently decreases the migratory and invasive abilities of two osteoblastic prostate cancer cell lines by inhibiting FAK, c-Src, and NF-κB transcriptional activity via the melatonin MT1 receptor, which effectively inhibits integrin α2 β1 expression. "
10/01/2000 - "In this communication, expression of mt1 melatonin receptor protein in human prostate cancer tissues and LNCaP cells was demonstrated by immunohisto(cyto)chemistry and western blotting, hence supporting the use of LNCaP cell line as a model for the study of melatonin signaling in prostate cancer cell growth. "
01/01/2021 - "Mechanistic investigations revealed that melatonin inhibits MMP-13 expression and the migratory and invasive capacities of prostate cancer cells via the MT1 receptor and the phospholipase C, p38, and c-Jun signaling cascades. "
01/01/2013 - "MT1 receptor-mediated inhibition of activated NF-κB signaling provides a novel mechanism supporting the use of melatonin in prostate cancer chemoprevention and therapy."