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Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)

Subscribe to New Research on Type 4 Melanocortin Receptor

A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH and ADRENOCORTICOTROPIC HORMONE.

Also Known As:

Melanocortin-4 Receptor; Receptor, Melanocortin, Type 4; MC4 Receptor; Melanocortin 4 Receptor; Receptor, Melanocortin-4; Receptor 4, Melanocortin; Receptor, MC4; Receptor, Melanocortin 4; Melanocortin Receptor 4

Networked: 452 relevant articles (9 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hinney, Anke: 17 articles (01/2013 - 03/2003)
2.	Hebebrand, Johannes: 16 articles (01/2013 - 08/2003)
3.	Cone, Roger D: 11 articles (04/2015 - 04/2003)
4.	Tao, Ya-Xiong: 11 articles (01/2014 - 10/2003)
5.	Marks, Daniel L: 11 articles (02/2013 - 04/2003)
6.	Hebebrand, J: 11 articles (07/2010 - 05/2001)
7.	O'Rahilly, Stephen: 10 articles (10/2014 - 03/2003)
8.	Farooqi, I Sadaf: 10 articles (10/2014 - 03/2003)
9.	Hinney, A: 10 articles (07/2010 - 05/2001)
10.	Haskell-Luevano, Carrie: 10 articles (06/2010 - 01/2004)

Related Diseases

1.	Obesity 04/01/2010 - "The relatively large effect of these common variants near melanocortin 4 receptor on general and visceral adiposity in childhood, especially in girls, could prove helpful in elucidating the molecular mechanisms underlying the development of obesity in early life." 03/01/2014 - "Human genome-wide association studies have identified genes associated with obesity and DM, including melanocortin 4 receptor (MC4R), which plays an important role in energy balance and appetite regulation. " 03/01/2014 - "Melanocortin 4 receptor (MC4R) is an important regulator of food intake and number of studies report genetic variations influencing the risk of obesity. " 02/01/2014 - "The aim of this study was to assess the association between melanocortin-4 receptor (MC4R) rs17782313 alleles with obesity and eating behavior scores in Chilean children. " 04/01/2012 - "This study investigated the prevalence of the Melanocortin receptor 4 (MC4R) V1031 gene variant and its association with obesity among a cohort of 254 patients (101 males; 118 obese) attending the Kampar Health Clinic. "
2.	Cachexia 10/01/2005 - "This review summarises the current evidence supporting the role of the melanocortin 4 (MC4) receptor subtype in cachexia, and discusses the development and use of small-molecule MC4 antagonists, which have proved to be effective in preventing the loss of lean body mass in animal models of cachexia. " 08/01/2007 - "Antagonism of the melanocortin 4 receptor (MC4R) has been proposed as a therapeutic intervention for the prevention of lean body mass waste, as in cachexia. " 07/01/2007 - "Regarding treatment potential, multiple reports describe the effectiveness of small molecule antagonists of the melanocortin-4 receptor in animal models of cachexia. " 04/01/2005 - "Recent findings strongly indicate that blockade of central melanocortin signaling through the MC4 receptor subtype attenuates cachexia. " 04/01/2005 - "MC4 receptor antagonists: a potential treatment for cachexia."
3.	Body Weight (Weight, Body) 08/22/2014 - "The melanocortin receptor 4 (MC4R) plays a major role in body weight regulation and its agonist MTII has been widely used to study the role of MC4Rs in energy expenditure promotion and feeding reduction. " 09/01/2008 - "Several studies have reported that carriers of the 103I allele of the melanocortin-4 receptor (MC4R) gene had lower body weight than did persons with the wild-type genotype. " 04/01/2015 - "Activation of the melanocortin-4 receptor (MC4R) with the synthetic agonist RM-493 decreases body weight and increases energy expenditure (EE) in nonhuman primates. " 01/01/2015 - "The central melanocortin system and particularly the melanocortin-4 receptor (MC4R) subtype, plays an important role in the regulation of body weight. " 11/18/2014 - "The melanocortin-4 receptor (MC4R) plays a key role in the regulation of food intake and body weight. "
4.	Anorexia 02/15/2001 - "Stimulation of the hypothalamic melanocortin 4 receptor (MC4-R) produces relative anorexia and increased metabolic rate, even in a relatively starved state. " 04/01/2000 - "However, we have also shown that the behavioral effects of CRF (anorexia and grooming) are not influenced by MC4 receptor blockage. " 04/01/2000 - "Moreover, immobilization stress-induced anorexia may be partially reversed by single and repeated intracerebroventricular administration of selective MC4 receptor antagonists. " 03/12/1999 - "We investigated the effects of selective melanocortin MC4 receptor blockage on immobilization stress-induced anorexia. " 03/12/1999 - "Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats."
5.	Brain Injuries (Brain Injury) 02/01/2015 - "In this study, we explore the protective effects of melanocortin 4 receptor agonists in IAH-induced brain injury. " 03/01/1999 - "We hypothesize that the up-regulation of melanocortin-4 receptor messenger RNA expression in the contralateral striatum may be involved in transfer of function to the uninjured hemisphere following unilateral brain injury." 03/01/1999 - "Melanocortin-4 receptor messenger RNA expression is up-regulated in the non-damaged striatum following unilateral hypoxic-ischaemic brain injury." 02/01/2015 - "The effects of the melanocortin 4 receptor agonist RO27-3225 in alleviating the rats' IAH brain injuries were observed, which indicated that RO27-3225 could reduce brain edema, the expressions of the IL-1β and TNF-α inflammatory cytokines, the blood-brain barrier's permeability and the aquaporin4 (AQP4) and matrix metalloproteinase 9 (MMP9) levels. "

Related Drugs and Biologics

1.	Hormones
2.	Eicosapentaenoic Acid
3.	Adrenocorticotropic Hormone (ACTH)
4.	NBI-12i
5.	glucagon-like peptide receptor (receptor, glucagon-like peptide)
6.	Leptin
7.	Leptin Receptors
8.	Melanocortin Receptors (Melanocortin Receptor)
9.	Agouti-Related Protein
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Intraventricular Infusions
2.	Acupuncture Therapy
3.	Gastric Bypass (Roux-en-Y Gastric Bypass)
4.	Bariatric Surgery
5.	Therapeutics