Melatonin Receptors (Melatonin Receptor)

A family of G-protein-coupled receptors that are specific for and mediate the effects of MELATONIN. Activation of melatonin receptors has been associated with decreased intracellular CYCLIC AMP and increased hydrolysis of PHOSPHOINOSITIDES.

Also Known As:

Melatonin Receptor; Receptors, Melatonin; MT3 Receptor; Mel(1c) Receptor; Melatonin MT3 Receptor; Receptor, Mel1c; Receptor, Melatonin; Receptor, Melatonin, 1C; Receptor, Melatonin, MT3; MT3 Receptor, Melatonin; Mel1c Receptor; Receptor, MT3; Receptor, Melatonin MT3

Networked: 590 relevant articles (38 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Melatonin Receptors: 590
        MT2 Melatonin Receptor: 90
        MT1 Melatonin Receptor: 62
        Xenopus melatonin 1a receptor
        Xenopus melatonin 1b receptor
  - Cytoplasmic and Nuclear Receptors: 3987
    - Melatonin Receptors: 590
      - Xenopus melatonin 1a receptor
      - Xenopus melatonin 1b receptor

Experts

1.	Jockers, Ralf: 13 articles (01/2021 - 01/2005)
2.	Reiter, Russel J: 10 articles (01/2020 - 10/2011)
3.	Dubocovich, Margarita L: 8 articles (08/2021 - 06/2002)
4.	Tosini, Gianluca: 8 articles (01/2019 - 09/2010)
5.	Qiu, Yong: 8 articles (09/2014 - 01/2006)
6.	Cardinali, Daniel P: 7 articles (01/2018 - 01/2008)
7.	Pandi-Perumal, Seithikurippu R: 7 articles (01/2018 - 01/2008)
8.	Laudon, Moshe: 7 articles (05/2016 - 02/2014)
9.	Blask, David E: 7 articles (10/2011 - 02/2002)
10.	Dauchy, Robert T: 7 articles (10/2011 - 02/2002)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 06/28/2023 - "Synthetic melatonin receptor agonists are prescribed for insomnia and depressive and circadian-related disorders. " 06/01/2015 - "Based on the fact that MT1 receptors are involved in human sleep onset process, melatonin receptor agonists have been developed to treat insomnia. " 12/01/2011 - "Melatonin receptor agonists: new options for insomnia and depression treatment." 01/01/2008 - "Hence, there is an urgent need for the development of melatonin receptor agonists with a longer half-life, which could be suitable for a successful treatment of insomnia. " 05/01/2000 - "Presentations ranged from the basic science of melatonin receptors to the epidemiology of untreated insomnia, and finally, to the education of primary care physicians. "
2.	Delirium 01/01/2022 - "Although a previous review illustrated the efficacy of melatonin receptor agonists (MRAs) in preventing delirium, some recent randomized controlled trials (RCTs) did not confirm these effects. " 09/01/2023 - "Efficacy and moderators of prevention and treatment of delirium with melatonin receptor agonists: A systematic review and meta-analysis of randomized controlled trials." 01/01/2022 - "Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials." 01/01/2021 - "Several clinical studies have reported that melatonin receptor agonists reduce delirium. " 01/01/2017 - "To review the prospective controlled trials available for the use of melatonin receptor agonists for delirium prevention. "
3.	Sleep Wake Disorders 11/01/2018 - "Increasingly, dual melatonin receptor agonists are being trialled in a variety of sleep disorders. " 06/15/2010 - "In the last years a variety of melatonin receptor agonists have been synthesized and evaluated for the treatment of sleep disorders. " 01/01/2008 - "Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders." 10/23/2020 - " this study, we investigate whether prophylactic administration of a sleep-inducing substance, a melatonin receptor agonist, is effective against sleep disorder after general anesthesia in patients with ASD. " 01/01/2022 - "In addition to the single effect of traditional melatonin receptor agonists on treating sleep onset insomnia, SMC had therapeutic potential for various sleep disorders, such as sleep onset insomnia and sleep maintenance insomnia. "
4.	Insulin Resistance 04/01/2018 - "Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity." 09/01/2010 - "Removal of melatonin receptor type 1 induces insulin resistance in the mouse." 04/03/2013 - "Loss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes. " 03/15/2014 - "Piromelatine, a novel melatonin receptor agonist, stabilizes metabolic profiles and ameliorates insulin resistance in chronic sleep restricted rats." 07/15/2013 - "Exogenous melatonin ameliorates insulin resistance in animals, while among humans, polymorphisms in the melatonin receptor gene are associated with insulin resistance. "
5.	Reperfusion Injury 01/01/2018 - "Activation of melatonin receptors protects the heart against ischemia-reperfusion injury. " 04/01/2016 - "The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury." 11/01/2008 - "Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions." 09/01/2014 - "Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1." 01/01/2020 - "Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury."

Related Drugs and Biologics

1.	Melatonin
2.	ramelteon (Rozerem)
3.	luzindole
4.	tasimelteon
5.	N- (2- (5- methoxy- indol- 3- yl)- ethyl)- 4- oxo- 4H- pyran- 2- carboxamide
6.	Antidepressive Agents (Antidepressants)
7.	MT2 Melatonin Receptor
8.	Histamine Antagonists (Antihistamines)
9.	Sirtuin 1
10.	Antipsychotic Agents (Antipsychotics)

Related Therapies and Procedures

1.	Therapeutics
2.	General Anesthesia
3.	Endarterectomy (Thromboendarterectomy)
4.	Treatment Delay
5.	Phototherapy (Light Therapy)