Lipoxins

Trihydroxy derivatives of eicosanoic acids. They are primarily derived from arachidonic acid, however eicosapentaenoic acid derivatives also exist. Many of them are naturally occurring mediators of immune regulation.

Also Known As:

Networked: 347 relevant articles (19 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Serhan, Charles N: 35 articles (12/2015 - 01/2002)
2.	Das, Undurti N: 25 articles (09/2015 - 07/2005)
3.	Godson, Catherine: 15 articles (07/2015 - 06/2002)
4.	Levy, Bruce D: 13 articles (10/2014 - 09/2002)
5.	Serhan, C N: 10 articles (01/2015 - 01/2000)
6.	Shang, You: 9 articles (02/2016 - 04/2010)
7.	Van Dyke, Thomas E: 8 articles (09/2015 - 01/2003)
8.	Chiang, Nan: 8 articles (09/2015 - 01/2002)
9.	Aliberti, Julio: 8 articles (01/2013 - 07/2002)
10.	Ye, Duyun: 8 articles (12/2012 - 01/2009)

Related Diseases

1.	Inflammation 02/01/2012 - "Temporal-metabolomic studies of local mediators during inflammation and its resolution uncovered novel pathways and mediators, e.g., lipoxins, resolvins, and protectins that stimulate key resolution responses. " 08/01/2011 - "In this study, we aimed to investigate the expression and potential role of lipoxin A(4) and FPR2/ALX in the regulation of inflammation associated with cyclical remodeling of the human endometrium across the menstrual cycle and during early pregnancy. " 12/01/2015 - "It is widely recognized that the resolution of inflammation is an active process, governed by specialized proresolving lipid mediators, including lipoxins, resolvins, maresins, and protectins. " 09/04/2015 - "Resolution of inflammation is an active biological process regulated by specialized lipid mediators including the lipoxins and resolvins. " 07/01/2015 - "Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice."
2.	Pancreatitis 04/10/2012 - "To explore the protective effects and possible mechanism of lipoxin A(4)-methyl ester (LXA(4)-ME) in rats with acute pancreatitis (AP). " 04/10/2012 - "[Protective effects and possible mechanism of lipoxin A(4) analogue in rats with acute pancreatitis]." 02/01/2011 - "Our aim was to investigate the protective effects of a Lipoxin A(4) analogue (LXA4) in the early phase of acute pancreatitis in rats. " 04/01/2014 - "BML-111, a lipoxin receptor agonist, ameliorates 'two-hit'-induced acute pancreatitis-associated lung injury in mice by the upregulation of heme oxygenase-1."
3.	Infection 01/01/2015 - "Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis." 12/01/2006 - "A recent study has uncovered an essential component of this handbrake system, revealing that lipoxins trigger suppressors of cytokine signalling to dampen inflammatory responses to infection. " 02/01/2014 - "Mice unable to synthesize lipoxin suffer increased lung pathology during respiratory syncytial virus infection. " 10/01/2008 - "Role of lipoxin in the modulation of immune response during infection." 05/12/2008 - "Lipoxins (LXs) are eicosanoid mediators that play key counterregulatory roles during infection. "
4.	Lung Injury 06/01/2012 - "We explored the role of COX-2 and lipoxin A(4) in experimental I/R-mediated lung injury. " 02/01/2016 - "BML-111 is a lipoxin receptor agonist that has protective effects in various lung injury models. " 06/01/2012 - "Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect." 04/01/2014 - "BML-111, a lipoxin receptor agonist, ameliorates 'two-hit'-induced acute pancreatitis-associated lung injury in mice by the upregulation of heme oxygenase-1." 05/01/2013 - "Treatment with lipoxin A4 and lipoxin receptor agonist (5(S), 6(R)-7-trihydroxymethyl 17 heptanoate) significantly stimulated AFC in oleic acid (OA)-induced lung injury, with the outcome of decreased pulmonary edema. "
5.	Anoxia (Hypoxia) 05/01/2013 - "Involvement of K+ channel-dependant pathways in lipoxin A4-induced protective effects on hypoxia/reoxygenation injury of cardiomyocytes." 04/01/2009 - "[Protective effects and its mechanism of lipoxins on human umbilical vein endothelial cells under hypoxia]." 04/01/1998 - "LXA4 stable analogs inhibited PMN transendothelial migration (1 nM-1 microM), and this PMN-EC responsiveness to inhibition by a lipoxin stable analog (e.g., 16-phenoxy-LXA4) was enhanced approximately 2 log orders of magnitude after hypoxia/reoxygenation. " 01/01/2013 - "Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex."

Related Drugs and Biologics

1.	lipoxin A4
2.	methyl ester 5(S),6(R)-7-trihydroxyheptanoic acid
3.	Aspirin (Acetylsalicylic Acid)
4.	Lipids
5.	Leukotrienes
6.	Eicosanoids
7.	Cytokines
8.	Heme Oxygenase-1
9.	S 6 (S-6)
10.	Leukotriene B4

Related Therapies and Procedures

1.	Analgesia
2.	Vagus Nerve Stimulation
3.	Transplants (Transplant)
4.	Angioplasty (Angioplasty, Transluminal)
5.	Therapeutics