Formyl Peptide Receptors (Formyl Peptide Receptor)

A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.
Also Known As:
Formyl Peptide Receptor; Receptors, Formyl Peptide; Chemoattractant Receptor; F-Chemotactic Peptide Receptor; FMLP Receptor; N-Formylmethionyl Peptide Receptor; N-formyl Hexapeptide Receptor; Receptor, Chemotactic Peptide; fMet-Leu-Phe Receptor; F Chemotactic Peptide Receptor; Hexapeptide Receptor, N-formyl; N Formylmethionyl Peptide Receptor; N formyl Hexapeptide Receptor; Peptide Receptor, Chemotactic; Peptide Receptor, N-Formylmethionyl; Peptide Receptors, Formyl; Receptor, Chemoattractant; Receptor, F-Chemotactic Peptide; Receptor, FMLP; Receptor, Formyl Peptide; Receptor, N-Formylmethionyl Peptide; Receptor, N-formyl Hexapeptide; Receptor, fMet-Leu-Phe; fMet Leu Phe Receptor; Chemotactic Peptide Receptor
Networked: 205 relevant articles (5 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Wang, Ji Ming: 21 articles (11/2014 - 01/2002)
2. Gong, Wanghua: 15 articles (09/2011 - 01/2002)
3. Iribarren, Pablo: 10 articles (07/2007 - 11/2003)
4. Chen, Keqiang: 9 articles (09/2011 - 11/2005)
5. Perretti, Mauro: 8 articles (12/2014 - 11/2003)
6. Bae, Yoe-Sik: 7 articles (04/2015 - 10/2003)
7. Le, Yingying: 7 articles (01/2005 - 01/2002)
8. Ryu, Sung Ho: 6 articles (04/2015 - 10/2003)
9. Hu, Jinyue: 6 articles (02/2006 - 10/2004)
10. Flower, Roderick J: 5 articles (12/2014 - 01/2009)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Bacterial Infections (Bacterial Infection)
3. Rhinitis
12/01/2013 - "Setipiprant, a tetrahydropyridoindole derivative, is a CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper [Th]-2 cells) antagonist that has the potential to be effective in the treatment of patients with diseases with an allergic etiology, such as allergic rhinitis and asthma. "
07/01/2005 - "The discovery of a second receptor for prostaglandin D2, chemoattractant receptor-homologous molecule expressed on T helper type 2 (CRTH2), has revived significant efforts into the development of small-molecule antagonists for allergic diseases as the receptor is predominantly expressed on cells such as eosinophils, TH2 cells and basophils, which are major pro-inflammatory cells in diseases such as asthma and allergic rhinitis. "
01/01/2011 - "The chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) is a G protein-coupled receptor that has been reported to modulate inflammatory responses in various rodent models of asthma, allergic rhinitis and atopic dermatitis. "
12/01/2014 - "Chemoattractant receptor-homologous molecule expressed on T helper (Th) 2 cells (CRTH2) is a G-protein-coupled receptor for prostaglandin D2 (PGD2), a key mediator in inflammatory disorders such as asthma and allergic rhinitis. "
01/01/2011 - "Prophylactic effects of the histamine H1 receptor antagonist epinastine and the dual thromboxane A2 receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells antagonist ramatroban on allergic rhinitis model in mice."
4. Fibrosis (Cirrhosis)
5. Seasonal Allergic Rhinitis (Hay Fever)

Related Drugs and Biologics

1. GTP-Binding Proteins (G-Protein)
2. Annexin A1
3. ramatroban
4. Indomethacin (Indometacin)
5. Trp-Lys-Tyr-Met-Val-Met
6. 4- butoxy- N- (2- (4- methoxy- phenyl)- 4- oxo- 1,4- dihydro- 2H- quinazolin- 3- yl)- benzamide
7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8. prostaglandin D2 receptor
9. Antigens
10. Chymases (Chymase)

Related Therapies and Procedures

1. Adjuvant Chemotherapy
2. Ligation
3. Drug Therapy (Chemotherapy)
4. Analgesia