Colonic Diverticulosis

A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.

Also Known As:

Networked: 33 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Diverticulitis
2.	Constipation
3.	Hemorrhage
4.	Diverticulum
5.	Adenomatous Polyps

Experts

1.	Mimura, Toshiki: 2 articles (03/2004 - 08/2002)
2.	Kamm, Michael A: 2 articles (03/2004 - 08/2002)
3.	La Tessa, C: 1 article (09/2014)
4.	Renda, A: 1 article (09/2014)
5.	Santangelo, M: 1 article (09/2014)
6.	Carrano, R: 1 article (09/2014)
7.	Piantadosi, M: 1 article (09/2014)
8.	Palmieri, D G: 1 article (09/2014)
9.	Carlomagno, N: 1 article (09/2014)
10.	Calogero, A: 1 article (09/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Colonic Diverticulosis:

1.	Narcotic Antagonists (Opioid Antagonists)IBA 01/01/2013 - "Recently published data question the importance of dietary fiber in the prevention of colonic diverticulosis and diverticulitis, and support the efficacy of a number of different therapies aimed at improving colonic motility and visceral sensation in constipation and reversing the effects of opioid induced constipation with peripherally acting opioid antagonists. "
2.	CollagenIBA 05/01/1996 - "This animal model permits a study of the relation between collagen crosslinkage and the development of colonic diverticulosis. " 02/01/2003 - "Ageing and the presence of colonic diverticulosis are associated with smaller more-tightly-packed collagen fibrils. " 09/01/1996 - "The incidence of colonic diverticulosis, submucosal collagen content, collagen solubility in weak acid, and the composition of intestinal contents were then measured. " 05/01/1996 - "Collagen alteration in an animal model of colonic diverticulosis." 07/01/1995 - "The acid solubility of the collagen, however, increased after the age of 40 years: at over 60 years, colonic diverticulosis was associated with an increased acid solubility ratio compared with values in unaffected colons (15.3 (0.2); compared with 9.2 (0.2), p < 0.001). "
3.	BariumIBA 07/01/1994 - "51 (3.2%) of 1610 barium enema studies showed colonic diverticulosis. " 07/01/1994 - "This study was aimed at determining the prevalence of colonic diverticulosis in northern India based on barium enema examination in symptomatic patients. " 12/14/2013 - "Pattern and distribution of colonic diverticulosis: analysis of 2877 barium enemas in Thailand." 12/01/2004 - "The assessment of the prevalence and distribution of colonic diverticulosis evaluated with barium enemas. " 07/01/1994 - "All barium enema examinations performed between January 1985 and December 1991 were reviewed for the presence of colonic diverticulosis. "
4.	Matrix MetalloproteinasesIBA 03/01/2004 - "This study was designed to investigate the role of collagens, matrix metalloproteinases, and tissue inhibitor of metalloproteinases in colonic diverticulosis. "
5.	Tissue Inhibitor of Metalloproteinases (TIMP)IBA 03/01/2004 - "Colonic diverticulosis is associated with altered collagen content and tissue inhibitor of metalloproteinases expression. " 03/01/2004 - "This study was designed to investigate the role of collagens, matrix metalloproteinases, and tissue inhibitor of metalloproteinases in colonic diverticulosis. "
6.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/01/2012 - "Since the patients who took aspirin and/or had bilateral colonic diverticulosis increased the risk of bleeding from divertuculi. " 09/15/2008 - "Main causes of GI bleeding with low-dose aspirin are gastroduodenal peptic ulcer and colonic diverticulosis. "
7.	Phenobarbital (Luminal)FDA Link 08/01/2007 - "Colonic diverticulosis is characterized by abnormal thickening of the bowel wall, associated with luminal overpressure and increase of sigmoid contractility. "
8.	ElastinIBA 08/01/2002 - "This chapter provides the evidence currently available for the pathophysiology of colonic diverticulosis and discusses its aetiological factors, including low dietary fibre, ageing and intraluminal pressure as well as extracelluar matrix such as collagen and elastin. "
9.	AntigensIBA 04/01/1988 - "One of 1 colonic diverticulosis, 2 of 2 ulcerative colitis, 3 of 3 villo-glandular polyps, 19 of 20 adenomatous polyps and 17 of 19 hyperplastic polyps were also stained heavily for the 1D3 antigen. "
10.	tiropramideIBA 06/01/1989 - "[Tiropramide hydrochloride in the premedication of diagnostic and therapeutic proctosigmoidocolonoscopy (endoscopic polypectomy) and the treatment of colonic diverticulosis]."

Therapies and Procedures

1.	Enema (Enemas) 01/01/2006 - "For 1,326 patients-56% male (n=741), 44% female (n=585), mean age 64 (+/-11.83 SD)-with a resection due to colonic cancer, the documented findings of colonoscopy, colonic contrast enema, and/or histopathology were analysed with regard to the prevalence of colonic diverticulosis. " 07/01/1994 - "51 (3.2%) of 1610 barium enema studies showed colonic diverticulosis. " 07/01/1994 - "This study was aimed at determining the prevalence of colonic diverticulosis in northern India based on barium enema examination in symptomatic patients. " 12/14/2013 - "Pattern and distribution of colonic diverticulosis: analysis of 2877 barium enemas in Thailand." 12/01/2004 - "The assessment of the prevalence and distribution of colonic diverticulosis evaluated with barium enemas. "
2.	Transplantation (Transplant Recipients) 01/01/1990 - "We reported a fatal case of perforation occurring on a colonic diverticulosis in the first month week post-transplantation. " 09/01/2014 - "This study aims to investigate possible risk factors for diverticulitis in kidney transplant recipients affected by colonic diverticulosis. " 07/01/2013 - "Perforated sigmoid diverticulitis, a complication of colonic diverticulosis commonly associated with autosomal dominant polycystic kidney disease (ADPKD), can be life-threatening in allogeneic kidney transplant recipients in the postoperative period. "
3.	Colectomy 07/01/2012 - "The benefits of laparoscopic (LC) versus open (OC) colectomy for symptomatic colonic diverticulosis as an elective operation remain unclear. " 03/01/1998 - "[Surgical morbidity of segmental colectomy ideally performed via laparotomy for complicated colonic diverticulosis]." 01/01/2004 - "The patient presented with gastrointestinal bleeding, and after being diagnosed with colonic diverticulosis, underwent a total colectomy. " 05/01/1985 - "The results were compared to those obtained in 5 colectomy specimens in patients with cancer of the rectum, without colonic diverticulosis (control series). " 07/01/1982 - "In 1969, the concept of "blind" subtotal colectomy was introduced for the treatment of patients with colonic diverticulosis and massive lower gastrointestinal (LGI) bleeding. "
4.	Endoscopes 05/01/1990 - "They studied the colonic diseases associated with the presence of diverticula (78 cases) and discussed the role of endoscope in the approach of colonic diverticulosis."
5.	Vagotomy 01/01/1989 - "The surgeon must attempt to cure the hemorrhage and to prevent recurrence at a later date by such measures as gastric resection and vagotomy for bleeding duodenal ulcers to prevent stomal ulcers, or by subtotal rather than segmental colectomy for widespread colonic diverticulosis. "