Endocannabinoids (Endocannabinoid)

03/01/2011 - "In conclusion a common haplotype in NAPEPLD, an enzyme involved in endocannabinoid synthesis, was protective against obesity."
01/01/2007 - "Experimental and clinic trials have demonstrated the efficacy of endocannabinoid antagonists in the management of obesity and the cardiometabolic syndrome. "
05/01/2005 - "Endogenous cannabinoids acting at CB(1) receptors stimulate appetite, and CB(1) antagonists show promise in the treatment of obesity. "
01/06/2015 - "The aim of this study was to determine the role of endocannabinoid signaling in glucocorticoid-mediated obesity and metabolic syndrome. "
09/01/2010 - "Both animal and human studies have associated the endocannabinoid system with obesity and markers of metabolic dysfunction. "

01/01/2013 - "This review will provide the reader with the foundational basic and clinical science linking the endocannabinoid system and the phytocannabinoids with their potentially therapeutic role in the management of chronic pain. "
09/01/2015 - "Given the well-described role of the endogenous cannabinoid (endocannabinoid; EC) system in the modulation of pain and attentional processing, the present study investigated its role in distraction-induced antinociception in rats. "
01/01/2009 - "However, many studies have shown that the endocannabinoid system interacts with other receptors and pathways to modulate pain at the peripheral level. "
01/01/2009 - "Recent studies indicate that the endocannabinoid system is dynamic and altered under different pathological conditions, including pain states. "
10/01/2004 - "Here, we review recent genetic, behavioral, and pharmacological studies that have tested the function of the endocannabinoid system in pain sensation. "

11/01/2011 - "Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss."
06/01/2011 - "These data show for the first time the effectiveness of the endocannabinoid system in attenuating the weight loss associated with the development of ABA via a mechanism involving reduced energy expenditure."
01/01/2011 - "Aerobic exercise training may preferentially modulate abdominal adipose tissue endocannabinoid-related gene expression during dietary weight loss."
04/01/2008 - "These favorable metabolic effects exceed by about 50% those anticipated by weight reduction, possibly due to modulation of the endocannabinoid system in peripheral tissues. "
02/01/2007 - "Interestingly, some of these beneficial metabolic effects are partially weight-loss-independent, confirming the importance of peripheral endocannabinoid system effects in addition to central effects."

10/01/2015 - "These studies suggest that CBD avoids the psychoactive effects of the endocannabinoid system to provide a well-tolerated, promising therapeutic for the treatment of seizures, while whole-plant cannabis can both contribute to and reduce seizures. "
10/01/2011 - "Endocannabinoid system and its CB1 receptors are suggested to provide endogeneous protection against seizures. "
08/17/2006 - "Here, we show that endocannabinoids directly target hippocampal glutamatergic neurons to provide protection against acute epileptiform seizures in mice. "
03/01/2015 - "The biology of the endocannabinoid system in the brain provides a possible basis for a beneficial pharmacological effect of marijuana on seizures. "
01/01/2015 - "Thus, the data argue that the endocannabinoid system plays an active role in seizure termination but does not regulate epileptogenesis."

02/01/2007 - "Yet to be developed substances that inhibit both endocannabinoid and PEA inactivation might be useful for the treatment of neuropathic pain."
11/01/2007 - "Herein we review recent studies of the effects of inhibition of metabolism of endocannabinoids versus uptake of endocannabinoids on nociceptive processing in models of inflammatory and neuropathic pain."
02/01/2014 - "Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors."
08/01/2013 - "We assessed in mice if age-dependent alterations of endocannabinoids contributed to the heightened vulnerability to neuropathic pain at old age. "
12/05/2012 - "Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system."