Cannabinoid Receptors (Cannabinoid Receptor)

A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.

Also Known As:

Networked: 1861 relevant articles (64 outcomes, 271 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Di Marzo, Vincenzo: 25 articles (04/2016 - 03/2002)
2.	Mackie, Ken: 24 articles (01/2022 - 12/2006)
3.	Maccarrone, Mauro: 22 articles (01/2021 - 07/2004)
4.	Zimmer, Andreas: 21 articles (04/2020 - 04/2005)
5.	Nagarkatti, Mitzi: 17 articles (06/2021 - 07/2002)
6.	Cravatt, Benjamin F: 17 articles (01/2021 - 06/2004)
7.	Rossi, Francesca: 16 articles (06/2022 - 12/2011)
8.	Guzmán, Manuel: 15 articles (01/2023 - 01/2003)
9.	Lutz, Beat: 15 articles (04/2020 - 04/2007)
10.	Lichtman, Aron H: 14 articles (10/2022 - 06/2004)

Related Diseases

1.	Pain (Aches) 04/01/2004 - "From a historical perspective to the present day, all the evidence suggests that activation of cannabinoid receptors (CBRs) is beneficial for gut discomfort and pain, which are symptoms related to dysmotility and visceral perception. " 11/17/2014 - "In particular, cannabinoid receptor 2 (CB2) has emerged as an attractive target for management of chronic pain, as demonstrated in several studies with inflammatory and neuropathic preclinical pain models. " 06/28/2016 - "The presence of these receptors could help to provide a description of cannabinoid receptors distribution and to better explain the role of fasciae as pain generator and the efficacy of some fascial treatments. " 10/01/2019 - "Recent studies indicated the two nociceptive receptors, cannabinoid receptor (CB) and transient receptor potential vanilloid type 1 (TRPV1) channel, are co-expressed in bone cells and play important role in the metabolism of bone cells, suggesting that dualtargeting these 2 receptors/channel may provide a novel approach for osteoporotic pain. " 08/01/2011 - "This study clearly shows that atypical cannabinoid receptors are involved in joint nociception and these novel targets may be advantageous for the treatment of inflammatory pain."
2.	Inflammation (Inflammations) 01/01/2016 - "Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying mechanism remains unclear. " 01/01/2022 - "In recent years, several studies pointed out the involvement of the cannabinoid receptor 2 (CB2r) in the immune system and the regulation of inflammation. " 11/07/2008 - "The purpose of this study was twofold: to confirm the presence of cannabinoid receptors in the bladder, the L6/S1 spinal cord, and dorsal root ganglia (DRG), and to determine the effects of acute and chronic bladder inflammation on expression of cannabinoid receptors. " 04/01/2008 - "The aim of our study was to seek out evidence for the presence of cannabinoid receptors in inflammatory endometrial tissue as well as for their potential role in endometrial inflammation. " 01/01/2023 - "Some cannabinoid receptors, which modulate proliferative and secretory responses in joint inflammation, have been functionally identified in human and animal synovial cells. "
3.	Obesity 09/23/2008 - "Cannabinoid receptor type 1 (CB1) antagonists show promise in the treatment of obesity and its metabolic consequences. " 03/01/2016 - "Cannabinoid receptor 1 (CB1) is the best-characterized cannabinoid receptor, and CB1 antagonists are used in clinical trials to treat obesity. " 12/27/2011 - "In vitro studies indicate a regulatory role for the cannabinoid receptor 1 (CB1) in adipocyte function and CB1-receptor deficient (CB1-/-) mice are resistant to high fat diet-induced obesity. " 01/01/2008 - "Different studies have investigated the relationship between polymorphisms of the cannabinoid receptor 1 (CNR1) gene and obesity with conflicting results. " 09/16/2022 - "While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested. "
4.	Fibrosis (Cirrhosis) 06/01/2015 - "The aim of the current study was to investigate the effects of cannabinoid receptor type 2 (CB2R) on the repair process of injured skeletal muscle, which could potentially lay solid foundations as a novel target for curing muscular fibrosis in future. " 01/01/2021 - "Previously, we showed that activated cannabinoid receptor type 2 (CB2) mediated kidney fibrosis. " 01/01/2020 - "A mosaic of biolipids, especially cannabinoid receptor 2 agonist, represents a rational therapeutic approach in fibrosis. " 11/01/2019 - "The cannabinoid receptor 1 is involved in renal fibrosis during chronic allograft dysfunction: Proof of concept." 01/01/2019 - "Antagonists of type 1 cannabinoid receptors (CB1) may be useful in treating diabetes, hepatic disorders, and fibrosis. "
5.	Reperfusion Injury 10/01/2020 - "The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat." 01/01/2019 - "Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway." 03/27/2008 - "There are conflicting reports in the literature describing the influence of cannabinoid receptor activation on ischemic/reperfusion injury. " 09/01/2012 - "We reported previously that both a cannabinoid receptor 2 (CB2R) agonist and a cannabinoid receptor 1 (CB1R) antagonist were protective in the treatment of transient middle cerebral artery occlusion/reperfusion injury (MCAO/R) and that they acted in a synergistic manner when administered in combination. " 01/01/2008 - "Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning."

Related Drugs and Biologics

1.	Cannabinoids
2.	Endocannabinoids
3.	Ligands
4.	Rimonabant
5.	Dronabinol (THC)
6.	Cannabidiol
7.	AM 251 (AM251)
8.	AM 1241
9.	Enzymes
10.	anandamide (arachidonylethanolamide)

Related Therapies and Procedures

1.	Electroacupuncture
2.	Analgesia
3.	Immunomodulation
4.	Therapeutics
5.	Drug Therapy (Chemotherapy)