Rotaxanes (Rotaxane)

Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.

Also Known As:

Networked: 56 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yui, Nobuhiko: 8 articles (08/2020 - 03/2014)
2.	Tamura, Atsushi: 7 articles (08/2020 - 03/2014)
3.	Nishida, Kei: 4 articles (08/2020 - 01/2016)
4.	Smith, Bradley D: 3 articles (06/2019 - 07/2010)
5.	Takata, Toshikazu: 3 articles (06/2016 - 01/2013)
6.	Wang, He: 3 articles (01/2016 - 05/2012)
7.	Zhou, Yi: 3 articles (01/2016 - 05/2012)
8.	Yang, Jie: 2 articles (01/2021 - 10/2018)
9.	Kang, Tae Woong: 2 articles (08/2020 - 01/2020)
10.	Masuda, Hiroki: 2 articles (08/2020 - 01/2020)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2016 - "The results presented in this study demonstrate cytotoxicity of the rotaxane compound and its potential as a lead compound for the development of a chemotherapeutic agent against cancer. " 01/01/2023 - "Biointerfaces based on polyrotaxanes can thus be a new platform for elucidating cancer cell migration and chemoresistance mechanisms." 11/09/2022 - "A rotaxane-based platform for tailoring the pharmacokinetics of cancer-targeted radiotracers." 06/01/2016 - "Neither the wheel nor the axle part alone inhibited tumor cell growth, suggesting that the complete rotaxane molecule with its unique "intramolecular mobility" is required to inhibit cell growth. " 06/01/2016 - "Here, we show that [2][bis(2-(3,5-dimethylphenylcarbonyloxy)ethyl) ammoniumtrifluoromethanesulfonate]-[dibenzo-24-crown-8] rotaxane (TRO-A0001), a rotaxane compound, exerted a growth inhibitory effect on several human cancer cell lines. "
2.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 02/09/2005 - "We report here the structure and properties of self-assembled monolayers (SAMs) of a bistable [2]rotaxane on Au (111) surfaces as a function of surface coverage based on atomistic molecular dynamics (MD) studies with a force field optimized from DFT calculations and we report several experiments that validate the predictions. " 05/14/2014 - "Here we report molecular level control over the spatial distribution of functional groups on surfaces utilizing self-assembled monolayers (SAMs) of pH-switchable surface-appended pseudorotaxanes. " 10/03/2012 - "This order is only achieved for the macrocycles through the deposition on the more rigid SAM template, whereas rotaxanes form oriented layers on both SAMs. " 03/14/2011 - "Preparation, reactivity and controlled release of SAMs of calix[4,6]arenes and calix[6]arene-based rotaxanes and pseudorotaxanes formed on polycrystalline Cu." 10/20/2003 - "Synthesis of a copper [3]rotaxane able to function as an electrochemically driven oscillatory machine in solution, and to form SAMs on a metal surface."
3.	Breast Neoplasms (Breast Cancer) 01/20/2021 - "In this study, a kind of hierarchically releasing bio-responsive nanoparticles (R(D)/H(S) NPs), constructed by β-cyclodextrin-grafted heparin and pH-sensitive pseudorotaxane, were investigated to enhance the breast cancer chemotherapeutic efficacy through TME modulation. "
4.	Bacterial Infections (Bacterial Infection) 07/21/2010 - "Optical imaging of bacterial infection in living mice using deep-red fluorescent squaraine rotaxane probes." 07/21/2010 - "The results indicate that fluorescent probes based on squaraine rotaxanes should be broadly useful for in vivo animal imaging studies, and they further validate the ability of imaging probes with bis(Zn-DPA) ligands to selectively target bacterial infections in living animals."
5.	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/01/2016 - "Lysosomal pH-inducible supramolecular dissociation of polyrotaxanes possessing acid-labile N-triphenylmethyl end groups and their therapeutic potential for Niemann-Pick type C disease." 04/10/2015 - "β-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease." 03/12/2014 - "Lysosomal-specific cholesterol reduction by biocleavable polyrotaxanes for ameliorating Niemann-Pick type C disease." 01/01/2017 - "Pluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease." 11/04/2015 - "Polyrotaxanes containing mixtures of HP-β-CD and SBE-β-CD were screened and found to be biologically active in an in vitro model of Niemann-Pick Type C disease where they mobilize aberrantly stored cholesterol similarly to monomeric cyclodextrin controls. "

Related Drugs and Biologics

1.	Cyclodextrins
2.	Folic Acid (Vitamin M)
3.	Ligands
4.	Polyethylene Glycols (Polyethylene Glycol)
5.	Heparin (Liquaemin)
6.	Fluorescent Dyes (Fluorescent Probes)
7.	DNA (Deoxyribonucleic Acid)
8.	squaraine
9.	Acids
10.	Polymers

Related Therapies and Procedures

1.	Therapeutics
2.	Quantum Dots (Quantum Dot)
3.	Semiconductor Lasers
4.	Lasers (Laser)
5.	Electrodes (Electrode)