Adenosine A1 Receptor

A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.

Also Known As:

Networked: 369 relevant articles (32 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mirnajafi-Zadeh, Javad: 6 articles (02/2013 - 01/2006)
2.	Boison, Detlev: 6 articles (07/2011 - 07/2003)
3.	Fathollahi, Yaghoub: 5 articles (05/2008 - 01/2006)
4.	Eisenach, James C: 5 articles (10/2006 - 05/2002)
5.	Li, Tianfu: 4 articles (07/2011 - 05/2007)
6.	Li, Xinhui: 4 articles (05/2005 - 05/2002)
7.	Masino, Susan A: 3 articles (01/2014 - 09/2009)
8.	Herrero, Juan F: 3 articles (08/2013 - 08/2005)
9.	Metra, Marco: 3 articles (05/2013 - 10/2008)
10.	O'Connor, Christopher M: 3 articles (05/2013 - 10/2008)

Related Diseases

1.	Ischemia 03/01/1997 - "Protection against global ischemia in the rabbit isolated heart 24 hours after transient adenosine A1 receptor activation." 04/01/1998 - "Pretreatment with either multiple episodes of ischemia or continuous infusion of a selective adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), resulted in attenuation of the protective effects of preconditioning, implying downregulation of the receptors involved in triggering classic preconditioning. " 08/01/2008 - "These results indicate that D1R activation presynaptically depresses excitatory synaptic transmission in striatal neurons after ischemia through activation of PKA and adenosine A1 receptors and thus demonstrate a novel mechanism of D1R-mediated protection against ischemia." 01/01/2015 - "As the adenosine A1 receptor activation confers protection against ischemia/reperfusion (I/R)-induced ventricular arrhythmias, we hypothesized that CBD may have antiarrhythmic effect through the activation of adenosine A1 receptor. " 12/01/1998 - "Overexpressing the adenosine A1 receptor also led to increased protection against ischemia-induced myocyte injury as well as an enhanced preconditioning effect. "
2.	Anoxia (Hypoxia) 01/01/2001 - "These results confirm the important role of adenosine A1 receptor agonist in protection against acute and chronic epileptogenic effect of hypoxia. " 11/01/2008 - "This study examined the effect of SF on ventilatory long-term facilitation (LTF, a persistent augmentation of respiratory activity after episodic hypoxia) and the hypoxic ventilatory response (HVR), and investigated the role of adenosine A1 receptors in these SF effects in conscious adult male Sprague-Dawley rats. " 09/28/2006 - "Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia." 01/01/2006 - "Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus." 01/01/2005 - "Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia."
3.	Seizures (Seizure) 05/01/2008 - "In this study, the role of adenosine A1 receptors of piriform cortex on CA1 hippocampal kindled seizures was studied in rats. " 06/22/2007 - "In this study, the effect of amygdala kindled seizures on adenosine A1 receptor-mediated neuromodulation in piriform cortex pyramidal neurons was tested at 24 h and 1 month after kindling. " 12/01/2006 - "In this study, the role of adenosine A1 receptors of the hippocampal CA1 region in entorhinal cortex-kindled seizures was investigated in rats. " 04/01/2015 - "Our findings indicate that the activation of adenosine A1 receptors is an important mechanism to control the development of seizures in zebrafish. " 04/01/2015 - "The adenosine A1 receptor agonist cyclopentyladenosine (CPA) increased the latency to reach the tonic-clonic seizure stage. "
4.	Poisoning 01/01/2004 - "Pretreatment with the peripheral adenosine A1 receptor antagonist 8- p-sulphophenyltheophylline (8-PST, 20 mg/kg i.p.) counteracted the cardiodepressant effects of 0.05 mg/kg CPA almost completely, thereby nearly abolishing its therapeutic efficacy against sarin poisoning. " 01/01/2004 - "Cardiovascular effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) decisive for its therapeutic efficacy in sarin poisoning." 07/01/2005 - "Efficacy of an adenosine A1 receptor agonist compared with atropine and pralidoxime in a rat model of organophosphate poisoning." 01/01/2006 - "We have demonstrated before that exposure of neuronal cultures to poisoning by iodoacetic acid (IAA) followed by "reperfusion" (IAA-R insult), results in severe cytotoxicity, which could be markedly attenuated by prior activation of the adenosine A1 receptors. " 01/01/2004 - "In conclusion, the present results strongly indicate that bradycardia and hypotension induced by the peripheral adenosine A1 receptor play a prominent role in the therapeutic efficacy of CPA in cases of sarin poisoning."
5.	Pain (Aches) 04/01/2013 - "Earlier studies have shown that activation of adenosine A1 receptors on peripheral pain fibers contributes to acupuncture-induced suppression of painful input. " 01/01/2011 - "The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. " 11/18/2010 - "Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats." 01/01/2007 - "In general, adenosine A1 receptors produce inhibitory effects on pain in a number of preclinical models and are a focus of attention. " 01/01/2005 - "Such pain-relieving effects, which are mostly mediated via central adenosine A1 receptor activation, have a slow onset and long duration of action, lasting usually for hours or days and occasionally for months. "

Related Drugs and Biologics

1.	Adenosine
2.	Sarin
3.	N(6)-cyclopentyladenosine
4.	1,3-dipropyl-8-cyclopentylxanthine
5.	Phenobarbital (Luminal)
6.	Carbamazepine (Tegretol)
7.	Pentylenetetrazole (Metrazol)
8.	Adenosine A3 Receptor
9.	Retinaldehyde (Retinal)
10.	Acetylcholine (Acetylcholine Chloride)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Topical Administration
3.	Ligation
4.	Stents
5.	Intravitreal Injections