Muscarinic M4 Receptor

A specific subtype of muscarinic receptor found in the CORPUS STRIATUM and the LUNG. It has similar receptor binding specificities to MUSCARINIC RECEPTOR M1 and MUSCARINIC RECEPTOR M2.

Also Known As:

Receptor, Muscarinic M4; M4 Receptor, Muscarinic; M4 Receptors, Muscarinic; M4, Muscarinic Receptor; M4, Muscarinic Receptors; Muscarinic M4 Receptors; Receptor M4, Muscarinic; Receptors M4, Muscarinic; Muscarinic Receptor M4; Muscarinic Receptors M4; Receptors, Muscarinic M4

Networked: 50 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Muscarinic Receptors: 2434
        Muscarinic M4 Receptor: 50
        human CHRM4 protein
      - Neurotransmitter Receptors: 562
        Cholinergic Receptors: 3880
        Muscarinic Receptors: 2434
        Muscarinic M4 Receptor: 50
        human CHRM4 protein

Experts

1.	Conn, P Jeffrey: 6 articles (10/2018 - 01/2014)
2.	Lindsley, Craig W: 4 articles (12/2020 - 11/2015)
3.	Wess, Jürgen: 3 articles (01/2016 - 03/2012)
4.	Dean, Brian: 2 articles (10/2021 - 05/2013)
5.	Jones, Carrie K: 2 articles (12/2020 - 01/2018)
6.	Rook, Jerri M: 2 articles (10/2018 - 01/2014)
7.	Bezard, Erwan: 2 articles (01/2016 - 11/2015)
8.	Cenci, M Angela: 2 articles (01/2016 - 11/2015)
9.	Fieblinger, Tim: 2 articles (01/2016 - 11/2015)
10.	Francardo, Veronica: 2 articles (01/2016 - 11/2015)

Related Diseases

1.	Dyskinesias (Dyskinesia) 01/01/2016 - "M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia." 11/18/2015 - "M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia."
2.	Schizophrenia (Dementia Praecox) 01/01/2020 - "Previous studies have linked muscarinic M4 receptors (CHRM4) to schizophrenia. " 01/01/2006 - "In a previous study we reported a decrease in the density of M1 and M2/M4 muscarinic receptors in the STG in schizophrenia. " 10/01/2018 - "Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents." 01/01/2018 - "Positive allosteric modulation of M1 and M4 muscarinic receptors as potential therapeutic treatments for schizophrenia." 05/01/2013 - "Although schizophrenia is a widespread disorder of unknown aetiology, we have previously shown that muscarinic M4 receptor (CHRM4) expression is decreased in the hippocampus and caudate-putamen from subjects with the disorder, implicating the receptor in its pathophysiology. "
3.	Alzheimer Disease (Alzheimer's Disease) 12/01/2022 - "The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease." 08/01/1997 - "Autoradiographic distribution of M1, M2, M3, and M4 muscarinic receptor subtypes in Alzheimer's disease." 01/01/2014 - "Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia." 07/01/2009 - "Patients with Alzheimer's disease (AD) reportedly exhibit hypersensitivity to much diluted tropicamide solution (0.005%), a M4 muscarinic receptor antagonist. " 01/01/2021 - "Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances, or psychosis, such as Alzheimer's disease or schizophrenia. "
4.	Psychotic Disorders (Schizoaffective Disorder) 06/20/2005 - "Upregulation of M2 and M4 muscarinic receptors in cingulate and adjacent cortex may thus contribute to the development of psychosis in DLB, with potential implications for treatments with drugs acting on these receptors." 01/01/2021 - "Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances, or psychosis, such as Alzheimer's disease or schizophrenia. "
5.	Brain Diseases (Brain Disorder) 10/01/2018 - "Metabotropic glutamate receptors and muscarinic M4 receptors have been proposed as novel targets for various brain disorders, including schizophrenia. " 01/01/2021 - "Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances, or psychosis, such as Alzheimer's disease or schizophrenia. "

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	Cholinergic Agents (Cholinergics)
3.	Analgesics (Analgesic Drugs)
4.	Complementary DNA (cDNA)
5.	Calcium Gluconate (CBG)
6.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate
7.	cinobufagin
8.	Antipsychotic Agents (Antipsychotics)
9.	Acetylcholine (Acetylcholine Chloride)
10.	Muscarinic M4 Receptor