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Muscarinic M4 Receptor

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A specific subtype of muscarinic receptor found in the CORPUS STRIATUM and the LUNG. It has similar receptor binding specificities to MUSCARINIC RECEPTOR M1 and MUSCARINIC RECEPTOR M2.

Also Known As:

Receptor, Muscarinic M4; M4 Receptor, Muscarinic; M4 Receptors, Muscarinic; M4, Muscarinic Receptor; M4, Muscarinic Receptors; Muscarinic M4 Receptors; Receptor M4, Muscarinic; Receptors M4, Muscarinic; Muscarinic Receptor M4; Muscarinic Receptors M4; Receptors, Muscarinic M4

Networked: 30 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - G-Protein-Coupled Receptors: 810
        Muscarinic Receptors: 1839
        Muscarinic M4 Receptor: 30
      - Neurotransmitter Receptors: 348
        Cholinergic Receptors: 856
        Muscarinic Receptors: 1839
        Muscarinic M4 Receptor: 30

Experts

1.	Wess, Jürgen: 3 articles (11/2015 - 07/2004)
2.	Conn, P Jeffrey: 2 articles (11/2015 - 01/2014)
3.	Bymaster, F P: 2 articles (08/2008 - 04/2001)
4.	Felder, C C: 2 articles (08/2008 - 04/2001)
5.	Huang, Xu-Feng: 2 articles (01/2006 - 03/2004)
6.	Katsifis, Andrew: 2 articles (05/2005 - 03/2004)
7.	Zavitsanou, Katerina: 2 articles (05/2005 - 03/2004)
8.	Karlsson, Evert: 2 articles (07/2004 - 08/2003)
9.	Lindsley, Craig W: 1 article (11/2015)
10.	Bezard, Erwan: 1 article (11/2015)

Related Diseases

1.	Dyskinesias (Dyskinesia) 11/18/2015 - "M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia."
2.	Schizophrenia (Dementia Praecox) 01/01/2006 - "In a previous study we reported a decrease in the density of M1 and M2/M4 muscarinic receptors in the STG in schizophrenia. " 05/01/2013 - "Although schizophrenia is a widespread disorder of unknown aetiology, we have previously shown that muscarinic M4 receptor (CHRM4) expression is decreased in the hippocampus and caudate-putamen from subjects with the disorder, implicating the receptor in its pathophysiology. " 05/01/2013 - "Cholinergic muscarinic M4 receptor gene polymorphisms: a potential risk factor and pharmacogenomic marker for schizophrenia." 08/05/2008 - "Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia." 01/01/2014 - "Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia."
3.	Neuroblastoma 09/01/1991 - "Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma x glioma hybrid (NG 108-15) cells." 12/01/1990 - "In a further series of experiments, we compared the affinity of six of the most discriminating antagonists in membranes from rabbit lung and NG108-15 cells, a neuroblastoma-glioma cell line reported to express the muscarinic m4 receptor gene. " 01/01/1991 - "Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors." 09/18/1990 - "(R)-Procyclidine showed a higher affinity for human neuroblastoma NB-OK 1 muscarinic M1 and rat striatum muscarinic M4 receptors, as compared to rat cardiac M2 receptors. " 11/01/1994 - "The regulation of m4 muscarinic acetylcholine receptor mRNA expression by receptor activation was studied in N1E-115 neuroblastoma and AtT-20 pituitary cells that endogeneously express the m4 muscarinic receptor. "
4.	Glioma (Gliomas) 09/01/1991 - "Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma x glioma hybrid (NG 108-15) cells." 12/01/1990 - "In a further series of experiments, we compared the affinity of six of the most discriminating antagonists in membranes from rabbit lung and NG108-15 cells, a neuroblastoma-glioma cell line reported to express the muscarinic m4 receptor gene. " 01/01/1995 - "We have further pursued those results in this study by investigating the effect of chlorpyrifos oxon in NG108-15 neuroblastoma-glioma cells and Chinese hamster ovary cells transfected with cDNA for human m2 or m4 muscarinic receptor subtypes. "
5.	Shock 01/01/2012 - "The study showed that M1 and M4 muscarinic receptors are involved in shock-limiting and shock-activating processes, respectively, while M3 receptors exert no effect on the course of posthemorrhagic abnormalities in systemic and hepatic portal circulation and on the posthemorrhagic lifespan. " 02/15/2006 - "Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model."

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	Complementary DNA (cDNA)
3.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate
4.	Muscarinic M4 Receptor
5.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
6.	Muscarinic M1 Receptor
7.	Muscarinic Agonists
8.	mu Opioid Receptors (mu Opioid Receptor)
9.	Tropicamide
10.	Messenger RNA (mRNA)