Carboxypeptidase B

A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. The enzyme catalyzes the preferential cleavage of a C-terminal peptidyl-L-lysine or arginine. It was formerly classified as EC 3.4.2.2 and EC 3.4.12.3.

Also Known As:

Networked: 63 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Robinson, William H: 4 articles (01/2014 - 10/2008)
2.	Song, Jason J: 4 articles (01/2014 - 10/2008)
3.	Nishimura, Toshihiko: 4 articles (09/2011 - 01/2008)
4.	Leung, Lawrence L K: 4 articles (07/2010 - 01/2008)
5.	Myles, Timothy: 4 articles (07/2010 - 01/2008)
6.	Appelros, S: 4 articles (01/2008 - 02/2001)
7.	Morser, John: 3 articles (09/2011 - 10/2009)
8.	Borgström, Anders: 3 articles (01/2009 - 01/2003)
9.	Borgström, A: 3 articles (01/2008 - 02/2001)
10.	Kubera, Anchanee: 2 articles (01/2022 - 11/2015)

Related Diseases

1.	Pancreatitis 01/01/2005 - "Active carboxypeptidase B is present in free form in serum from patients with acute pancreatitis." 08/01/1985 - "Using this assay, we were able to detect, for the first time, active carboxypeptidase B in sera from patients with acute pancreatitis. " 01/01/1998 - "Activation peptide of carboxypeptidase B in serum and urine in acute pancreatitis." 04/01/1995 - ""Human pancreas-specific protein" (procarboxypeptidase B): a valuable marker in pancreatitis?" 08/01/2002 - "To investigate levels of procarboxypeptidase B (proCAPB) and its activation peptide in serum in acute pancreatitis to test the accuracy of these two variables as markers for the diagnosis of acute pancreatitis and for prediction of pancreatic necrosis. "
2.	Chronic Kidney Failure (Chronic Renal Failure) 05/01/1996 - "In conclusion, in patients with chronic renal failure, the elevation of serum procarboxypeptidase B is as common as the elevations of other pancreatic enzymes." 05/01/1996 - "The current study was conducted in order to evaluate the frequency and degree of elevated serum levels of procarboxypeptidase B in chronic renal failure and their correlations with serum levels of amylase, lipase and renal function tests. " 05/01/1996 - "Serum procarboxypeptidase B, amylase and lipase in chronic renal failure."
3.	Glomerulonephritis 01/01/2007 - "In the present study, the effects of EF6265, a novel specific plasma carboxypeptidase B inhibitor, on renal dysfunction in a rat thrombotic glomerulonephritis model were examined. " 01/01/2007 - "EF6265, which inhibits plasma carboxypeptidase B, showed a protective effect on thrombotic renal dysfunction in thrombotic glomerulonephritis through enhancing the fibrinolysis." 01/01/2007 - "EF6265, a novel plasma carboxypeptidase B inhibitor, protects against renal dysfunction in rat thrombotic glomerulonephritis through enhancing fibrinolysis."
4.	Neoplasms (Cancer) 01/01/1985 - "The amount of enkephalin immunoreactivity present initially in these tumors was greatly augmented by the prohormone activators trypsin or trypsin plus carboxypeptidase B, suggesting that most of the immunoreactive enkephalin was present in higher molecular weight precursor form. " 01/01/1986 - "In combination with trypsin and carboxypeptidase B cleavage, radioimmunoassays based on these antisera measured progastrins in some extra-antral tissues and certain malignant tumors. " 11/01/1984 - "Secretion of peptidyl-glycine alpha-amidating monooxygenase (PAM) activity and enkephalin convertase (a carboxypeptidase B-like enzyme) activity from AtT-20 mouse corticotrope tumor cells was compared with secretion of pro-ACTH/endorphin-derived peptides. " 06/01/2011 - "Immune related transcripts in the library were carboxypeptidase B, ferritin, translationally controlled tumor proteins (TCTP), hemocyanin, chitinase and serine carboxy peptidase. " 12/01/1982 - "We have previously established that secretory proteins from a rat acinar cell tumor lack two forms of procarboxypeptidase B, are deficient in a major lipase species, and possess markedly reduced amounts of the basic proteins proelastase, basic chymotrypsinogen, basic trypsinogen and ribonuclease (Iwanij, V., and J.D. "
5.	Inflammation (Inflammations) 07/01/2010 - "To determine whether procarboxypeptidase B (pCPB)(-/-) mice are susceptible to accelerated abdominal aortic aneurysm (AAA) development secondary to unregulated OPN-mediated mural inflammation in the absence of CPB inhibition. " 10/01/2008 - "Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)." 01/01/2008 - "Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)." 05/01/2004 - "The activated enzyme, TAFIa, displays carboxypeptidase B-like activity and probably regulates both fibrinolysis and inflammation in response to injury and infection. " 01/01/2022 - "Innate immune pathways, such as the complement- and pattern-recognition receptor pathways, are pivotal to the inflammation in OA and key components of the innate immune system implicated in OA include DAMP-TLR signaling, the complement system, carboxypeptidase B (CPB), and mononuclear cells. "

Related Drugs and Biologics

1.	Lipase (Acid Lipase)
2.	Amylases
3.	Peptides (Polypeptides)
4.	Proteins (Proteins, Gene)
5.	carboxypeptidase B activation peptide
6.	7- amino- 2- (((2- methyl- 1- (3- phenylpropanoylamino)propyl)hydroxyphosphinoyl)methyl)heptanoic acid
7.	Trypsinogen
8.	Trypsin
9.	Enzymes
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics