Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)

A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM.

Also Known As:

Networked: 93 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mizutani, Shigehiko: 11 articles (11/2013 - 11/2002)
2.	Llorens-Cortes, Catherine: 7 articles (08/2014 - 05/2004)
3.	Mizutani, S: 5 articles (03/2015 - 01/2000)
4.	Marc, Yannick: 5 articles (08/2014 - 05/2008)
5.	Larrinaga, Gorka: 5 articles (01/2014 - 02/2007)
6.	Nomura, Seiji: 5 articles (09/2008 - 11/2002)
7.	Ramírez-Expósito, María Jesús: 4 articles (09/2014 - 10/2011)
8.	López, José I: 4 articles (01/2014 - 02/2007)
9.	Perez, Itxaro: 4 articles (01/2014 - 11/2011)
10.	Sanz, Begoña: 4 articles (01/2014 - 11/2011)

Related Diseases

1.	Pre-Eclampsia (Preeclampsia) 03/01/1996 - "In conclusion this study demonstrates for the first time that increased villous trophoblastic angiotensinase A activity indicates an increased likelihood of the presence of pre-eclampsia and the severity of hypertensive disorders in pregnancy." 03/01/1996 - "Enhanced villous trophoblastic angiotensinase A activity was significantly associated with an increased frequency of pre-eclampsia in pregnant women (cumulative odds ratio x 0(1) 6.37; P < 0.001) and showed significant correlations with the severity of gestational hypertensive disorders, represented by systolic (r = 0.31; P < 0.05) and diastolic (r = 0.34; P < 0.05 blood pressure and by concomitant proteinuria (r = 044; P < 0.01). " 03/01/1996 - "Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension." 01/01/1987 - "Serum aminopeptidase A (AAP) activity was measured in normal pregnancy and pre-eclampsia. " 01/01/1987 - "Serum aminopeptidase A (AAP) in normal pregnancy and pregnancy complicated by pre-eclampsia."
2.	Premature Obstetric Labor (Premature Labor) 11/01/2013 - "The authors conclude that both aminopeptidase A and placental leucine aminopeptidase could be potentially safe and effective drugs for patients and their babies in the treatment of preeclampsia and preterm labor." 01/01/2011 - "Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia." 03/01/2015 - " changes of the balance between fetal angiotensin II (A-II) and vasopressin (AVP) andA-II and AVP degrading enzymes, between aminopeptidase A (APA) and placental leucine aminopeptidase( P-LAP) - in the placenta and maternal blood due to fetal stress such as hypoxia - are the provable causes of preeclampsia or preterm labor.Induction"
3.	Hypertension (High Blood Pressure) 06/01/2005 - "Association study: the aminopeptidase a gene and essential hypertension." 08/01/2014 - "A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors." 01/01/2014 - "Here we review new insights into the predominant role of brain Ang III in the control of BP, underlining the fact that brain aminopeptidase A (APA), the enzyme generating brain Ang III, may therefore be an interesting candidate target for the treatment of hypertension. " 01/01/2014 - "[Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension]." 08/30/2013 - "Structural insights into central hypertension regulation by human aminopeptidase A."
4.	Neoplasms (Cancer) 11/12/2010 - "Aminopeptidase A (APA; EC 3.4.11.7) is a transmembrane metalloprotease with several functions in tumor angiogenesis. " 07/01/2010 - "Here we exploited a peptide ligand of aminopeptidase A (APA), discovered by phage display technology for delivery of liposomal DXR to perivascular tumor cells. " 02/01/2004 - "We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. " 02/01/2007 - "Aminopeptidase B activity of the particulate fraction in tumors decreases (t = 2,399 vs. n = 13,536 UP/mg protein; P < 0.001) compared with nontumor tissues, and aspartyl-aminopeptidase activity decreases significantly in CCRCC (t = 137 vs. n = 223 UP/mg protein; P < 0.05). " 10/01/1978 - "When cultured mouse fibroblast strain C3H2K and rat fibroblast strain 3Y1 cells were transformed by SV40 or by a ts A mutant and maintained at permissive temperature, aminopeptidase A activity was drastically decreased, and the ratio of aminopeptidase A to aminopeptidase B was reduced to the levels of tumor cells. "
5.	Breast Neoplasms (Breast Cancer) 10/01/2011 - "We observed an increase in aminopeptidase N (APN) and aminopeptidase B (APB) activities in women with breast cancer; however, a decrease in aspartyl-aminopeptidase (AspAP) activity in premenopausal women. " 03/01/2006 - "Aminopeptidase N (APN), aminopeptidase B (APB) and aminopeptidase A (aspartyl- and glutamyl-aminopeptidase, APA) activities are measured in the pineal gland of rats with breast cancer induced by N-methyl nitrosourea (NMU). " 05/01/2012 - "The aim of this study was to investigate the putative changes in serum angiotensinase activities (aminopeptidase N, APN; aminopeptidase B, APB; aminopeptidase A, APA; aspartyl aminopeptidase, ASAP) involved in the renin-angiotensin system (RAS) in women with breast cancer treated or not with a neoadjuvant therapy of paclitaxel and anthracycline and in healthy women volunteers. "

Related Drugs and Biologics

1.	leucyl-cystinyl aminopeptidase
2.	CD13 Antigens (Alanine Aminopeptidase)
3.	Enzymes
4.	Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)
5.	Angiotensin III
6.	aminopeptidase B
7.	Insulin (Novolin)
8.	angiotensinase
9.	Paclitaxel (Taxol)
10.	Palladium

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Surgical Instruments (Clip)