DNA-Formamidopyrimidine Glycosylase (Formamidopyrimidine DNA Glycosylase)

A DNA repair enzyme that is an N-glycosyl hydrolase with specificity for DNA-containing ring-opened N(7)-methylguanine residues.

Also Known As:

Formamidopyrimidine DNA Glycosylase; FAPY-DNA Glycosylase; DNA Formamidopyrimidine Glycosylase; FAPY DNA Glycosylase; Formamidopyrimidine-DNA Glycosylase

Networked: 24 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - N-Glycosyl Hydrolases: 36
        DNA Glycosylases: 334
        DNA-Formamidopyrimidine Glycosylase: 24
        Arabidopsis FPG1 protein
        Arabidopsis FPG2 protein
        Arabidopsis FPG3 protein
        E coli DNA-formamidopyrimidine glycosylase
  - DNA Repair Enzymes: 492
    - DNA Glycosylases: 334
      - DNA-Formamidopyrimidine Glycosylase: 24
        Arabidopsis FPG1 protein
        Arabidopsis FPG2 protein
        Arabidopsis FPG3 protein
        E coli DNA-formamidopyrimidine glycosylase

Experts

1.	Frosina, Guido: 3 articles (03/2010 - 06/2007)
2.	Başaran, A A: 2 articles (08/2016 - 10/2013)
3.	Başaran, N: 2 articles (08/2016 - 10/2013)
4.	Taner, G: 2 articles (08/2016 - 10/2013)
5.	Şahin, T: 2 articles (08/2016 - 10/2013)
6.	Aydın, Sevtap: 2 articles (11/2014 - 11/2014)
7.	Bacanlı, Merve: 2 articles (11/2014 - 11/2014)
8.	Başaran, A Ahmet: 2 articles (11/2014 - 11/2014)
9.	Başaran, Nurşen: 2 articles (11/2014 - 11/2014)
10.	Taner, Gökçe: 2 articles (11/2014 - 11/2014)

Related Diseases

1.	Sepsis (Septicemia) 10/01/2013 - "This study has been undertaken to assess the role of RV on the sepsis-induced oxidative DNA damage in the lymphocytes of Wistar albino rats by the standard and formamidopyrimidine DNA glycosylase (Fpg)-modified comet assays. " 11/01/2014 - "Sepsis-induced DNA damage in the lymphocytes, liver and kidney cells of rats were evaluated by comet assay with and without formamidopyrimidine DNA glycosylase (Fpg). " 11/01/2014 - "In the lymphocytes, kidney, and liver tissue cells of the sepsis-induced rats, Pyc treatment significantly decreased the DNA damage and oxidative base damage using standard alkaline assay and formamidopyrimidine DNA glycosylase-modified comet assay, respectively. " 08/01/2016 - "The aim of this study was to investigate the effects of RA on sepsis-induced DNA damage in the lymphocytes and liver and kidney cells of Wistar albino rats by alkaline comet assay with and without formamidopyrimidine DNA glycosylase protein. "
2.	Cockayne Syndrome (Syndrome, Cockayne) 06/15/2007 - "Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase." 03/01/2010 - "Defective repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III." 01/01/2008 - "To conceive new therapeutic strategies for this syndrome, we are investigating whether the oxidatively damaged DNA repair defect in Cockayne syndrome might be complemented by heterologous repair proteins, such as the Escherichia coli formamidopyrimidine-DNA glycosylase and endonuclease III. The complementation studies may shed light on the important lesions for the Cockayne syndrome phenotype and offer new tools for future therapies aimed at counteracting the consequences of oxidatively damaged DNA accumulation."
3.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/01/2005 - "This study evaluates DNA damage (strand breakage, base oxidation, formamidopyrimidine DNA glycosylase (Fpg) sensitive sites), H2O2-induced DNA damage, a marker of DNA susceptibility to oxidation and glutathione (GSH) level, a powerful antioxidant, in women with polycystic ovary syndrome (PCOS). "
4.	Asthma (Bronchial Asthma) 06/01/2010 - "The aim of this study was to describe DNA damage as level of DNA strand breaks and formamidopyrimidine DNA glycosylase (Fpg)-sensitive sites, which reflects oxidative DNA damage and GSH level in children with mild-to-moderate persistent asthma; and to examine the effect of antiasthmatic therapy on these DNA damage parameters and GSH level. "
5.	Photosensitivity Disorders (Photodermatitis) 06/01/2015 - "FICZ photosensitization caused intracellular oxidative stress, and comet analysis revealed introduction of formamidopyrimidine-DNA glycosylase (Fpg)-sensitive oxidative DNA lesions suppressible by antioxidant cotreatment. " 01/14/1992 - "Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Proteins (Proteins, Gene)
3.	Endonucleases
4.	Antioxidants
5.	Anti-Asthmatic Agents (Antiasthmatic Drugs)
6.	Glutathione (Reduced Glutathione)
7.	Enzymes
8.	Messenger RNA (mRNA)
9.	purine
10.	DNA Glycosylases (DNA Glycosylase)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)