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beta-Fructofuranosidase (Invertase)

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A glycoside hydrolase found primarily in PLANTS and YEASTS. It has specificity for beta-D-fructofuranosides such as SUCROSE.

Also Known As:

Invertase; Saccharase; Sacrosidase; Sucraid; Acid Invertase; Sucrose 6-Phosphate Hydrolase; beta-Fructosidase; 6-Phosphate Hydrolase, Sucrose; Hydrolase, Sucrose 6-Phosphate; Invertase, Acid; Sucrose 6 Phosphate Hydrolase; beta D Fructofuranosidase; beta Fructofuranosidase; beta Fructosidase; beta-D-Fructofuranosidase

Networked: 83 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Drug Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Glycoside Hydrolases: 275
      - beta-Fructofuranosidase: 83
        Arabidopsis Inv1 protein
        Oryza sativa CYT-INV1 protein
        preinvertase
        S cerevisiae SUC2 protein
        S pombe INV1 protein

Experts

1.	Roitsch, Thomas: 4 articles (06/2015 - 12/2006)
2.	Hause, Bettina: 3 articles (07/2012 - 08/2007)
3.	Roitsch, T: 3 articles (01/2011 - 01/2003)
4.	Amao, Yutaka: 3 articles (06/2003 - 07/2002)
5.	Balibrea, María Encarnación: 2 articles (06/2015 - 02/2015)
6.	van der Graaff, Eric: 2 articles (06/2015 - 02/2015)
7.	Albacete, Alfonso: 2 articles (06/2015 - 02/2015)
8.	Arias, Cintia L: 2 articles (06/2015 - 02/2015)
9.	Großkinsky, Dominik K: 2 articles (06/2015 - 02/2015)
10.	Weckwerth, Wolfram: 2 articles (06/2015 - 02/2015)

Related Diseases

1.	Body Weight (Weight, Body) 09/01/2004 - "(3) IGF1, IGFBP3 were positively correlated to intestinal VH, VSA, saccharase, body weight and length. " 05/01/1996 - "1. Body weight, digestive organ weights, and activities of disaccharidases (maltase and saccharase) activities were determined from day of hatch to 21 d of age in meat- and egg-type chickens. " 07/28/2005 - "Serum leptin, body weight (BW), body length (BL), intestinal weight (IW), intestinal length (IL), and intestinal disaccharidase (including lactase, maltase, and saccharase) were detected. " 12/15/1986 - "The distribution of radioactivity and arylsulfatase in a sucrose gradient was established after isopycnic centrifugation of the ML fraction of rats injected with 125I-invertase, the animals having received or not an injection of 900 micrograms/100 g body weight of unlabelled invertase 15 h before killing. " 11/01/1978 - "Experiments on male rats showed that following subcutaneous injection of alloxan in a dose of 15 mg per 100 g of body weight amylolytic, invertase, glycyl-l-tyrosine dipeptidehydrolase activity of the mucosa of the small intestine altered differently. "
2.	Shock 04/01/2002 - "The effects of ste24- and spf1-null mutations on invertase secretion are additive, cell generation time is increased 60%, and cells become sensitive to cold and to heat shock. " 09/01/1984 - "To define a system for studying this problem, we examined invertase transcription after various physiological perturbations of cells: rapid catabolite derepression, heat shock, and cell cycle arrest. " 12/25/2015 - "Furthermore, heat shock at the late-log glucose growth phase also improved endogenous invertase yield by approximately 2.7-fold. " 09/01/1984 - "We propose that invertase mRNA regulation involves constitutively synthesized transcriptional factors (observed during catabolite derepression) and transient factors (observed during heat shock and possibly during synchronous growth). " 09/01/1984 - "We concluded that (i) catabolite-derepressed synthesis of the mRNAs occurs rapidly after a drop in glucose, is a sustained response, and does not require de novo protein synthesis; (ii) heat shock transcription of both invertase mRNAs is, in contrast, a brief and transient response requiring de novo protein synthesis; and (iii) alpha-mating hormone treatment (G1 phase arrest and release) results in regular and coordinated synthesis of both mRNAs midway between rounds of histone mRNA synthesis. "
3.	Infection 11/01/2010 - "Whereas studies have focused so far only on the transcriptional induction of invertase genes in response to pathogen infection, the role of post-translational regulation of invertase activity has been neglected and was the focus of the present study. " 06/01/2006 - "Although many researchers have found an increase in invertase activity upon infection, only a few studies were able to determine whether the source of this activity was host or parasite. " 01/01/2015 - "Furthermore, the Populus invertase genes displayed differential expression in roots, stems, leaves, leaf buds and in response to salt/cold stress and pathogen infection. " 08/01/2011 - "The activity of the extracellular invertase in developing ears increased as a plant response to pathogen infection, especially when the plants were irrigated at the time of inoculation. " 11/01/2010 - "Upon pathogen infection, the invertase activity is released by repression of invertase inhibitor expression, thus linking the local induction of sink strength to the plant defense response."
4.	Dehydration (Water Stress) 06/01/2015 - "Ectopic overexpression of the cell wall invertase gene CIN1 leads to dehydration avoidance in tomato." 02/01/2015 - "Ectopic overexpression of the cell wall invertase gene CIN1 leads to dehydration avoidance in tomato." 12/01/2004 - "Acid invertase (EC 3.2.1.26) activity was also enhanced by the water stress and associated with the change in fructan concentration, but not correlated with the total NSC remobilization and (14)C increase in the grains. " 09/01/2000 - "A maize vacuolar invertase, IVR2, is induced by water stress. " 01/01/1997 - "Whereas in water-stressed plants increased contents of the phytohormone ABA are supposed to mediate the adaptation to water stress, no contribution of ABA to reduction of photosynthesis could be detected in invertase transformants."
5.	Tetraploidy 01/01/2010 - "For functional studies on natural variants of five potato invertase genes we cloned and sequenced 193 full-length cDNAs from six heterozygous individuals (three tetraploid and three diploid). " 06/01/2012 - "We have PCR-isolated and sequenced the alleles of the apoplastic invertase inhibitor gene (Stinh1) from three tetraploid potato genotypes: 1021/1 (a genotype with very high tolerance to CIS), 'Karaka' and 'Summer Delight' (two cultivars that are highly susceptible to CIS). "

Related Drugs and Biologics

1.	Lactase
2.	Glucose (Dextrose)
3.	Enzymes
4.	Dactinomycin (Ac-De)
5.	Disaccharidases
6.	Hexoses
7.	Alkaline Phosphatase
8.	Sucrose (Saccharose)
9.	Carbohydrates
10.	Platinum

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Subcutaneous Injections