HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Aryldialkylphosphatase (Paraoxonase)

Subscribe to New Research on Aryldialkylphosphatase

An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).

Also Known As:

Paraoxonase; Aryl-dialkyl Phosphatase; Arylalkylphosphatase; Homocysteine Thiolactone Hydrolase; OPA Anhydrase; OPH Enzyme; Organophosphorus Acid Anhydrase; Organophosphorus Acid Anhydrolase; Organophosphorus Acid Hydrolase; Organophosphorus Hydrolase; Paraoxonase-1; Paraoxonase-2; Acid Anhydrase, Organophosphorus; Acid Anhydrolase, Organophosphorus; Acid Hydrolase, Organophosphorus; Anhydrase, OPA; Anhydrase, Organophosphorus Acid; Anhydrolase, Organophosphorus Acid; Aryl dialkyl Phosphatase; Enzyme, OPH; Hydrolase, Homocysteine Thiolactone; Hydrolase, Organophosphorus; Hydrolase, Organophosphorus Acid; Paraoxonase 1; Paraoxonase 2; Phosphatase, Aryl-dialkyl; Thiolactone Hydrolase, Homocysteine

Networked: 1182 relevant articles (25 outcomes, 207 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Phosphoric Triester Hydrolases: 9
        Aryldialkylphosphatase: 1182
        human PON1 protein: 3
        human PON2 protein

Experts

1.	Mackness, Bharti: 25 articles (12/2013 - 08/2002)
2.	Erel, Ozcan: 22 articles (09/2015 - 03/2007)
3.	Camps, Jordi: 18 articles (12/2013 - 05/2002)
4.	Joven, Jorge: 18 articles (12/2013 - 05/2002)
5.	Aksoy, Nurten: 16 articles (12/2014 - 01/2008)
6.	Reddy, Srinivasa T: 14 articles (11/2013 - 09/2003)
7.	Aslan, Mehmet: 13 articles (09/2015 - 03/2007)
8.	Marsillach, Judit: 13 articles (12/2013 - 11/2005)
9.	Celik, Hakim: 13 articles (10/2013 - 01/2007)
10.	Gugliucci, Alejandro: 11 articles (01/2015 - 02/2007)

Related Diseases

1.	Atherosclerosis 04/01/2003 - "Paraoxonase 1, an HDL-associated enzyme that confers antioxidant activity on HDL, and its activity in serum have been correlated with protection against atherosclerosis, an oxidative disease. " 09/01/2014 - "Now-a-days, there are only few studies which have presented the correlation between antioxidant enzyme HDL-associated-paraoxonase 1(PON1) and Hcy in atherosclerosis. " 10/25/2010 - "Since paraoxonase enzyme (PON) is a bioscavenger against both atherosclerosis and organophosphate toxicity, studies on paraoxonase enzyme (PON) occupy an important place in the scientific world. " 06/01/2010 - "This study was designed to evaluate the paraoxonase 1 (PON1) activity and oxidant/antioxidant status in Saudi women with PCOS and its contribution to the risk of atherosclerosis. " 01/01/2010 - "In this study, a recombinant adeno-associated virus (rAAV) vector carrying the human paraoxonase-1 (hPON1) gene (rAAV-PON1) was constructed, and endothelial progenitor cells (EPCs) transfected with rAAV-PON1 were transplanted into the atherosclerosis model of Sprague-Dawley rats (SD rats). "
2.	Poisoning 04/01/1995 - "These results indicate that exogenous paraoxonase offers significant protection against CPS toxicity when administered both before and after the organophosphate, suggesting that it may be considered as a potential additional treatment of organophosphate poisoning." 10/01/1993 - "A number of lines of evidence suggest that serum paraoxonase is protective against poisoning by organophosphorus substrates of this enzyme. " 04/01/1997 - "The increase of serum paraoxonase activity in developing animals correlates well with the increased resistance to organophosphate poisoning that has been reported in previous studies." 07/01/2015 - "[Role and significance of paraoxonase in acute organophosphate poisoning]." 04/01/2011 - "To provide toxicokinetic and clinical evidence of the hydrolytic effect of paraoxonase-1 (PON1) on acute organophosphate poisoning in rats. "
3.	Coronary Artery Disease (Coronary Atherosclerosis) 01/01/2014 - "Previous studies have shown an association between paraoxonase (PON) activity and the presence and severity of coronary atherosclerosis. " 06/01/2012 - "The aim of this study was to investigate serum paraoxonase-1 enzyme activity (SPA) in patients with CAE in comparison patients with coronary artery disease (CAD) and normal coronary arteries. " 01/01/2012 - "Previous studies examined associations between polymorphisms in the paraoxonase 1 (PON1) gene and development of coronary artery disease (CAD), with inconsistent results. " 03/01/2009 - "A preliminary study of human paraoxonase and PON 1 L/M55-PON 1 Q/R 192 polymorphisms in Turkish patients with coronary artery disease." 01/01/2009 - "Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study."
4.	Coronary Disease (Coronary Heart Disease) 10/01/2004 - "The antioxidant enzyme paraoxonase 1 (PON1) has previously been suggested to confer protection against coronary heart disease (CHD), one of the main causes of death in the Western world. " 06/01/1997 - "Recent studies have implicated paraoxonase, an HDL-associated enzyme, in providing protection against LDL oxidation, thus affecting the risk of coronary heart disease (CHD) in the general population. " 07/01/2009 - "Previous studies of genetic variants of paraoxonase 1 (PON1) and coronary heart disease (CHD) have been conflicting and the modifying effects of lifestyle factors that affect PON1 activity are uncertain. " 04/01/2008 - "Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: the PRIME study." 02/28/2004 - "Although there have been suggestions that serum paraoxonase is important in protecting against coronary heart disease (CHD), a large number of studies of genetic determinants of serum paraoxonase have reported apparently conflicting results about their association with CHD. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 03/01/2000 - "Recent studies indicate that the enzyme paraoxonase may be an important modulator of cardiovascular disease risk because of its ability to protect LDL from oxidation. " 01/01/1997 - "Paraoxonase was identified as a genetic risk factor for cardiovascular disease (CVD) in recent studies focusing on a polymorphism affecting position 191. " 10/01/2015 - "Decreased activity of the enzyme paraoxonase-1 (PON1) has been demonstrated in cardiovascular diseases. " 01/01/2015 - "Review: The role of paraoxonase in cardiovascular diseases." 12/01/2014 - "Recently, ample evidence has suggested a common etiologic factor, namely, reduced HDL-associated paraoxonase 1 (PON1) activity, as a causative factor in the development of PMOP and cardiovascular disease (CVD). "

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Lipids
3.	Aryldialkylphosphatase (Paraoxonase)
4.	Cholesterol
5.	arylesterase
6.	Enzymes
7.	Homocysteine
8.	Superoxide Dismutase
9.	Peroxidase (Myeloperoxidase)
10.	HDL Cholesterol

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)
3.	Aftercare (After-Treatment)
4.	Bariatric Surgery
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)