Phosphodiesterase I (5' Exonuclease)

A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.

Also Known As:

5' Exonuclease; 5'-Exonuclease; 5'-Nucleotidephosphodiesterase; Alkaline Phosphodiesterase; Alkaline Phosphodiesterase I; Oligonucleate 5'-Nucleotidohydrolase; Orthophosphoric Diester Phosphohydrolase; 5' Nucleotidephosphodiesterase; Diester Phosphohydrolase, Orthophosphoric; Oligonucleate 5' Nucleotidohydrolase; Phosphodiesterase I, Alkaline; Phosphodiesterase, Alkaline; Phosphohydrolase, Orthophosphoric Diester

Networked: 59 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Diester Hydrolases: 2391
        Phosphodiesterase I: 59
        snake venom phosphodiesterase I: 4

Experts

1.	Posadas-Romero, Carlos: 4 articles (02/2015 - 01/2012)
2.	Vargas-Alarcón, Gilberto: 4 articles (02/2015 - 01/2012)
3.	Medina-Urrutia, Aida: 3 articles (02/2015 - 01/2013)
4.	Villarreal-Molina, Teresa: 3 articles (02/2015 - 01/2013)
5.	Cardoso-Saldaña, Guillermo: 2 articles (02/2015 - 09/2014)
6.	Posadas-Sánchez, Rosalinda: 2 articles (02/2015 - 01/2013)
7.	Pérez-Hernández, Nonanzit: 2 articles (02/2015 - 01/2012)
8.	Rodríguez-Pérez, José Manuel: 2 articles (02/2015 - 01/2012)
9.	Alvarez-León, Edith: 2 articles (09/2014 - 01/2013)
10.	Kimura-Hayama, Eric: 2 articles (09/2014 - 01/2013)

Related Diseases

1.	Infections 12/01/2000 - "In this study, the course of infection of GBV-B in tamarins was followed using a real-time 5' exonuclease (TaqMan) reverse transcription-PCR assay to determine the level of GBV-B in the serum. " 07/04/2012 - "TaqMan-based 5'exonuclease RT-PCR with type-specific primers was used to assess HPV16 and 18 infections and genome status. " 07/01/2015 - "The deoxynucleoside triphosphate triphosphohydrolase and 3' → 5' exonuclease SAMHD1 restricts HIV-1 infection in noncycling hematopoietic cells in vitro, and SAMHD1 mutations are associated with AGS. " 04/01/1984 - "Activation of alveolar, peritoneal, liver, and spleen macrophages was measured by decreased 5'-nucleotidase and elevated alkaline phosphodiesterase I activities in newborn and juvenile guinea pigs for up to 48 days after intracardiac or intranasal infection with Mycobacterium microti. " 04/01/1984 - "Macrophage activation measured by changes in 5'-nucleotidase and alkaline phosphodiesterase I activities after infection of newborn and juvenile guinea pigs with mycobacterium microti."
2.	Breast Neoplasms (Breast Cancer) 01/01/1979 - "Serum phosphodiesterase I (PDE I) activity was determined in 13 control and 51 breast-cancer patients with various stages of disease. " 01/01/1979 - "Serum phosphodiesterase I activity in breast cancer patients." 11/15/2006 - "This tracing system combined with an allele-specific reverse primer and vent (exo-) DNA polymerase, a polymerase that lacks 3'- to 5'-exonuclease activity, was used for the detection of point mutations of base G in codon 259 (AGA) of exon 7 of p53 gene on a panel of breast cancer individuals." 09/01/1975 - "Preliminary studies indicate that phosphodiesterase I activity is greater than normal in serum of patients with necrotic changes in the liver or kidney or in cases of breast cancer, but not in that of patients with myocardial infarction, bone cancer, lung cancer, or chronic liver cirrhosis."
3.	Myocardial Infarction 01/01/2012 - "Seven polymorphisms in the MMP genes were genotyped by 5' exonuclease TaqMan genotyping assays in 300 patients with myocardial infarction and 300 healthy unrelated controls. " 09/01/1975 - "Preliminary studies indicate that phosphodiesterase I activity is greater than normal in serum of patients with necrotic changes in the liver or kidney or in cases of breast cancer, but not in that of patients with myocardial infarction, bone cancer, lung cancer, or chronic liver cirrhosis."
4.	Carcinogenesis 05/01/1996 - "To study the role of HCAs in human carcinogenesis, we analyzed MeIQx-DNA adducts in 38 DNA samples obtained from surgical and autopsy specimens by the 32P-postlabeling method under adduct-intensification conditions with the modification of additional digestion with nuclease P1 and phosphodiesterase I after 32P-labeling at 5'-hydroxyl termini. "
5.	Chromosomal Instability (Chromosome Stability) 10/06/2022 - "WRN, the gene responsible for WS, encodes DNA helicase with a 3' to 5' exonuclease activity, and numerous studies have revealed that WRN helicase is involved in the maintenance of chromosome stability through actions in DNA, e.g., DNA replication, repair, recombination, and epigenetic regulation via interaction with DNA repair factors, telomere-binding proteins, histone modification enzymes, and other DNA metabolic factors. "

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Related Therapies and Procedures

1.	Ligation