Myosin-Light-Chain Phosphatase

A phosphoprotein phosphatase that is specific for MYOSIN LIGHT CHAINS. It is composed of three subunits, which include a catalytic subunit, a myosin binding subunit, and a third subunit of unknown function.

Also Known As:

Calponin Phosphatase; Myosin Light Chain Phosphatase; Myosin Phosphatase; Smooth Muscle MBP; Smooth Muscle Myosin-bound Phosphatase; Smooth Muscle Phosphatase-I; Smooth Muscle Phosphatase-II; Muscle Phosphatase-II, Smooth; Phosphatase, Calponin; Phosphatase, Myosin; Phosphatase, Myosin-Light-Chain; Phosphatase-II, Smooth Muscle; Smooth Muscle Myosin bound Phosphatase; Smooth Muscle Phosphatase I; Smooth Muscle Phosphatase II

Networked: 96 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Tao: 5 articles (06/2011 - 01/2008)
2.	Xu, Jing: 5 articles (06/2011 - 01/2008)
3.	Fisher, Steven A: 4 articles (01/2021 - 05/2004)
4.	Liu, Liangming: 4 articles (06/2011 - 01/2008)
5.	Yang, Guangming: 4 articles (06/2011 - 01/2008)
6.	Brozovich, Frank V: 3 articles (01/2018 - 09/2004)
7.	Shimokawa, Hiroaki: 3 articles (12/2014 - 04/2007)
8.	Ming, Jia: 3 articles (06/2010 - 01/2008)
9.	Kaibuchi, K: 3 articles (11/2000 - 03/2000)
10.	Cole, William C: 2 articles (01/2021 - 01/2017)

Related Diseases

1.	Muscle Spasticity (Spastic) 03/21/2000 - "These results indicate that Rho-kinase is upregulated at the spastic site and plays a key role in inducing vascular smooth muscle hypercontraction by inhibiting myosin phosphatase through the phosphorylation of MBS in our porcine model." 02/01/2005 - "In animal models with coronary spasm Rho-kinase is upregulated at the spastic site and plays a key role in inducing vascular smooth muscle hypercontraction by inhibiting myosin light chain phosphatase, resulting in enhancement of its phosphorylation. " 03/21/2000 - "Western blot analysis showed that during the serotonin-induced contractions, the extent of phosphorylation of the myosin-binding subunit of myosin phosphatase (MBS), one of the major substrates of Rho-kinase, was significantly greater in the spastic than in the control segment and that the increase in MBS phosphorylations was also markedly inhibited by Y-27632. "
2.	Infarction (Infarctions) 02/08/2008 - "Administration of fasudil twice daily was continued until day 4. Fasudil prevented the accumulation of neutrophils within the brain as seen from measurements taken on day 3, and improved neuronal functions and reduced the infarction area as seen on day 5. Fasudil and hydroxyfasudil, an active metabolite of fasudil, concentration-dependently inhibited phosphorylation of myosin binding subunit of myosin phosphatase in neutrophils. "
3.	Hypoxia (Hypoxemia) 08/01/2014 - "The augmentation of contraction caused by hypoxia or cIMP was accompanied by increased phosphorylation of myosin phosphatase target subunit 1 at Thr(853), which was prevented by the ROCK inhibitor Y-27632. " 05/13/2009 - "MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)." 12/01/2008 - "Auto-phosphorylation of srcFKs and phosphorylation of the regulatory subunit of myosin phosphatase (MYPT-1) and myosin light-chain (MLC(20)) in response to hypoxia were determined by western blotting. " 10/01/2003 - "Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells: role of Rho-kinase." 01/01/2010 - "In hypoxia-treated vascular smooth muscle cells (VSMCs), the effects of PKC-alpha and PKC-epsilon agonists on protein expression and activity of CPI-17 and ZIPK and the modulating effects of CPI-17 and ZIPK on the regulation of PKC-alpha and PKC-epsilon on the activity of myosin light chain phosphatase (MLCP) were observed. "
4.	Neoplasms (Cancer) 07/01/2009 - "We propose that Myosin phosphatase is a crucial and tightly controlled regulator of cell behaviors during gastrulation and that understanding its role in early development also provides insight into the mechanism of cancer cell invasion." 05/01/2009 - "Stable knockdown of ROCK2 in HCC cells significantly inhibited Golgi reorientation, myosin phosphatase phosphorylation, and formations of stress fibers, filopodia, and lamellipodia; these molecular and cellular events are crucial for cell motility and cancer invasion. " 01/01/2018 - "Our previous study demonstrated that Myosin Phosphatase Targeting subunit 1 (MYPT1) may function as a direct target of microRNA-30d, which promotes tumor angiogenesis and tumor growth of prostate cancer (PCa). " 11/13/2023 - "Cohort data available from the Cancer Genome Atlas showed that high expression of PPP1R12A, PP1B encoding the catalytic subunit of the myosin phosphatase complex, or ATP8A1 correlated with poor prognosis in breast cancer patients. " 01/01/2023 - "Furthermore, microRNA-675-ablation increased the expression levels of myosin phosphatase targeting protein 1 (MYPT1) to inactivate the tumor-initiating RhoA/NF2/YAP1 signal pathway, and downregulation of MYPT1 recovered the malignant phenotypes in microRNA-675-silenced GISTs cells. "
5.	Hypertension (High Blood Pressure) 02/27/2023 - "Our previous study revealed that vascular smooth muscle cell (VSMC)-specific myosin phosphatase target subunit 1 (MYPT1) knockout (MYPT1SMKO) leads to constant hypertension, prompting us to explore whether hypertensive MYPT1SMKO mice can be considered a novel CSVD animal model. " 07/01/2007 - "Therefore, our results show that preservation of GLUT4 expression prevents enhanced arterial reactivity in hypertension, possibly via effects on myosin phosphatase activity." 03/07/2003 - "Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle." 01/01/2018 - "Rho-kinase activity is determined in circulating leukocytes measuring phosphorylation of its target myosin phosphatase target subunit 1 (MYPT1), but its relationship with Rho-kinase activity in the myocardium and in vasculature in hypertension has not been evaluated.The" 01/01/2012 - "An impaired balance between Rho-kinase and myosin phosphatase activities induces the abnormal sustained phosphorylation of MLC, which contributes to the pathogenesis of certain vascular diseases, such as vasospasm and hypertension. "

Related Drugs and Biologics

1.	Myosins (Myosin)
2.	rho-Associated Kinases
3.	fasudil (AT 877)
4.	Y 27632
5.	Serotonin (5 Hydroxytryptamine)
6.	hydroxyfasudil
7.	Myosin Light Chains (Myosin Essential Light Chain)
8.	Myosin-Light-Chain Kinase
9.	Calcium
10.	Mitogen-Activated Protein Kinases

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)