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Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)

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A thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIONE and the C-terminal glycine residue of UBIQUITIN.

Also Known As:

Ubiquitin Carboxy-Terminal Hydrolase; Ubiquitin C-Terminal Esterase; Ubiquitin C-Terminal Hydrolase; Ubiquitin Carboxy-Terminal Esterase; C-Terminal Esterase, Ubiquitin; C-Terminal Hydrolase, Ubiquitin; Carboxy-Terminal Esterase, Ubiquitin; Carboxy-Terminal Hydrolase, Ubiquitin; Esterase, Ubiquitin C-Terminal; Esterase, Ubiquitin Carboxy-Terminal; Hydrolase, Ubiquitin C-Terminal; Hydrolase, Ubiquitin Carboxy-Terminal; Thiolesterase, Ubiquitin; Ubiquitin C Terminal Esterase; Ubiquitin C Terminal Hydrolase; Ubiquitin Carboxy Terminal Esterase; Ubiquitin Carboxy Terminal Hydrolase

Networked: 94 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Thiolester Hydrolases
        Ubiquitin Thiolesterase: 94
        human BAP1 protein
        human STAMBP protein
        human STAMBPL1 protein
        human Ubiquitin carboxyl-Terminal Hydrolase L-1
        human UCHL1 protein
        human USP10 protein
        human USP12 protein
        human USP14 protein
        human USP16 protein
        human USP20 protein
        human USP21 protein
        human USP24 protein
        human USP25 protein
        human USP28 protein
        human USP33 protein
        human USP36 protein
        human USP4 protein
        human USP40 protein
        human USP6 protein
        human USP7 protein
        human USP8 protein
        human USP9X protein
        human USP9Y protein
        mouse PGP9.5 protein
        mouse Stambp protein
        mouse Ubiquitin carboxyl-Terminal Hydrolase L-1
        mouse UCHL3 protein
        mouse Usp14 protein
        mouse Usp8 protein
        rat PGP9.5 protein
        rat UCH-L1 protein
        rat Usp2 protein
        S cerevisiae DOA4 protein
        S cerevisiae UBP10 protein
        S cerevisiae UBP16 protein
        Xenopus Usp16 protein
        zebrafish Uch-L1 protein

Experts

1.	Wada, Keiji: 8 articles (09/2013 - 10/2004)
2.	Hayes, Ronald L: 7 articles (01/2014 - 01/2010)
3.	Kabuta, Tomohiro: 4 articles (05/2013 - 08/2008)
4.	Mondello, Stefania: 4 articles (05/2012 - 01/2012)
5.	Zhao, Zhonghua: 3 articles (08/2015 - 01/2008)
6.	Zhang, Zhigang: 3 articles (08/2015 - 01/2008)
7.	Uchida, Kenko: 3 articles (05/2013 - 04/2010)
8.	Wang, Kevin K W: 3 articles (05/2012 - 01/2010)
9.	Papa, Linda: 3 articles (05/2012 - 01/2010)
10.	Brophy, Gretchen M: 3 articles (05/2012 - 01/2010)

Related Diseases

1.	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 07/01/2014 - "Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis." 07/01/2014 - "Renal ubiquitin C-terminal hydrolase L1 (UCHL1) is upregulated in a subset of human glomerulopathies, including focal segmental glomerulosclerosis (FSGS), where it may serve to promote ubiquitin pools for degradation of cytotoxic proteins. "
2.	Parkinson Disease (Parkinson's Disease) 02/15/2012 - "Genetic studies have implicated the neuronal ubiquitin C-terminal hydrolase (UCH) protein UCH-L1 in Parkinson's disease (PD) pathogenesis. " 01/01/2014 - "The ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene has been implicated in the etiology of Parkinson's disease (PD). " 08/01/2011 - "Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is an intracellular protein abundantly expressed in neurons, and a mutation in UCH-L1 has been identified in familial Parkinson's disease. " 04/01/2011 - "The ubiquitin carboxy-terminal hydrolase L1 gene (UCH-L1) has been implicated in the etiology of Parkinson's disease (PD). " 12/01/2010 - "The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. "
3.	Brain Injuries (Brain Injury) 05/01/2012 - "This study compared early serum levels of ubiquitin C-terminal hydrolase (UCH-L1) from patients with mild and moderate traumatic brain injury (TBI) with uninjured and injured controls and examined their association with traumatic intracranial lesions on computed tomography (CT) scan (CT positive) and the need for neurosurgical intervention (NSI). " 09/01/2015 - "Serum ubiquitin C-terminal hydrolase L1 (UCH-L1) has been proposed as a biomarker of traumatic brain injury (TBI). " 09/01/2015 - "Serum ubiquitin C-terminal hydrolase L1 as a biomarker for traumatic brain injury: a systematic review and meta-analysis." 03/01/2012 - "Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury." 12/01/2011 - "Elevated serum ubiquitin carboxy-terminal hydrolase L1 is associated with abnormal blood-brain barrier function after traumatic brain injury."
4.	Neoplasms (Cancer) 09/01/2013 - "This review will focus on ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a DUB that is attributed to both cancer and neurodegeneration. " 05/03/2013 - "Ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed in a restricted range of tissues, including the brain and numerous types of cancer. " 09/01/2010 - "Ubiquitin C-terminal hydrolase (UCH)-L1 is a DUB of unknown function that is overexpressed in several human cancers, but whether it has oncogenic properties has not been established. " 01/01/2009 - "Ubiquitin C-terminal Hydrolase L1 (UCH L1) has been linked to several neurological diseases as well as human cancer, but the physiological targets and the regulation of UCH L1 expression in vivo have been largely unexplored. " 12/12/2006 - "Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) has garnered attention for its links with Parkinson's disease and cancer; however, the mechanism of action of this enzyme in cells remains poorly understood. "
5.	Breast Neoplasms (Breast Cancer) 04/01/2009 - "BRCA1-associated protein-1 (Bap1) is a ubiquitin carboxy-terminal hydrolase and is frequently mutated in lung and sporadic breast tumors. " 03/05/1998 - "BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth and is the first nuclear-localized ubiquitin carboxy-terminal hydrolase to be identified. " 10/01/2013 - "Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients." 06/01/2006 - "The present study investigated the mRNA expression level of ubiquitin c-terminal hydrolase (UCH)-L1 and -L3 in breast cancer tissue and aimed to elucidate its association with tumor characteristics and patient prognosis. "

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