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11-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Also Known As:
11 beta-Hydroxysteroid Dehydrogenase Type 2; 11 beta-HSD2; 11beta-HSD2; 11beta-HSD2 Reductase; 11beta-Hydroxysteroid Dehydrogenase Type 2; 11 beta Hydroxysteroid Dehydrogenase Type 2; 11beta Hydroxysteroid Dehydrogenase Type 2
Networked: 193 relevant articles (1 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Frey, Brigitte M: 11 articles (01/2014 - 05/2003)
2. Stewart, Paul M: 11 articles (06/2009 - 01/2002)
3. Frey, Felix J: 10 articles (01/2014 - 05/2003)
4. Seckl, Jonathan R: 7 articles (01/2009 - 08/2003)
5. Sasano, Hironobu: 7 articles (01/2008 - 11/2002)
6. Stewart, P M: 7 articles (03/2004 - 01/2001)
7. Frey, F J: 7 articles (06/2002 - 03/2000)
8. Suzuki, Takashi: 6 articles (12/2005 - 11/2002)
9. Dick, Bernhard: 5 articles (02/2009 - 05/2003)
10. Frey, B M: 5 articles (06/2002 - 10/2000)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Fetal Growth Retardation (Intrauterine Growth Retardation)
3. Essential Hypertension
4. Pre-Eclampsia (Preeclampsia)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Enzymes
2. Sodium
3. 11-beta-Hydroxysteroid Dehydrogenase Type 1
4. Gonadal Steroid Hormones (Sex Hormones)
5. Messenger RNA (mRNA)
6. Hydrocortisone (Cortisol)
7. Mineralocorticoids
8. Glucocorticoids
9. Mineralocorticoid Receptors (Mineralocorticoid Receptor)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Therapeutics
2. Ligation
3. Renal Dialysis (Hemodialysis)
4. Colectomy