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Carboxylesterase (Hydrolase S)

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Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.

Also Known As:

Hydrolase S; Ali-esterase; B-esterase; CAP-hydrolyzing Enzyme; Capsaicin-Hydrolyzing Enzyme; Carboxyesterase; Carboxylate Esterase; Carboxylester Lipase; Carboxylesterase B; Carboxylic Ester Hydrolase; Esterase 10; Esterase 13; Esterase 3; Esterase 6A; Esterase 8; Esterase ES-1A; Isocarboxazid amidase; Naproxen Esterase; Non-specific Carboxylesterase; Non-specific Esterase; Nonspecific Esterase; Procaine Esterase; Ali esterase; B esterase; CAP hydrolyzing Enzyme; Capsaicin Hydrolyzing Enzyme; Carboxylesterase, Non-specific; ES-1A, Esterase; Enzyme, CAP-hydrolyzing; Enzyme, Capsaicin-Hydrolyzing; Ester Hydrolase, Carboxylic; Esterase ES 1A; Esterase, Carboxylate; Esterase, Naproxen; Esterase, Non-specific; Esterase, Nonspecific; Esterase, Procaine; Hydrolase, Carboxylic Ester; Lipase, Carboxylester; Non specific Carboxylesterase; Non specific Esterase; amidase, Isocarboxazid

Networked: 341 relevant articles (2 outcomes, 17 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Potter, Philip M: 12 articles (09/2010 - 09/2002)
2.	Danks, Mary K: 8 articles (01/2007 - 09/2002)
3.	Hyatt, Janice L: 5 articles (01/2008 - 06/2004)
4.	Morton, Christopher L: 5 articles (12/2005 - 09/2002)
5.	Danks, M K: 4 articles (05/2008 - 05/2000)
6.	Aboody, Karen S: 3 articles (02/2012 - 01/2007)
7.	Kim, Seung U: 3 articles (02/2012 - 01/2007)
8.	Najbauer, Joseph: 3 articles (02/2012 - 01/2007)
9.	Hosokawa, Masakiyo: 3 articles (08/2010 - 09/2006)
10.	Wierdl, Monika: 3 articles (04/2010 - 08/2003)

Related Diseases

1.	Carcinoma (Carcinomatosis) 02/01/1986 - "[Histochemical study on nonspecific esterase in large intestine carcinoma]." 04/01/2012 - "Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. " 11/01/2006 - "Transcriptome analysis following introduction of a constitutively active form of p53 (p53T18D/S20D) into colon carcinoma cell lines identified transcriptional activation of the carboxylesterase 2 (CES-2) gene, which is involved in drug metabolism. " 06/01/1993 - "Peripheral blood smears (n = 22) or cytocentrifuge preparations (n = 52) of mononuclear cells from the peripheral blood of patients with gastrointestinal carcinoma were stained by the non-specific esterase stain (pH 5.8) using a batch technique. " 07/01/1982 - "[Submicroscopic localization of nonspecific esterase in carcinomas of the upper jaw]."
2.	Poisoning 09/01/1999 - "A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning." 09/01/2010 - "In mice, the combination of the carboxylesterase inhibitor 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide (CBDP) with the organophosphorus (OP) nerve agent GB renders mice more sensitive to OP poisoning. " 04/01/2010 - "The drug-metabolizing enzyme human carboxylesterase 1 (hCE1) is a candidate protein-based therapeutic because of its similarity in structure and function to the cholinesterase targets of nerve agent poisoning. " 01/01/2013 - "mori after insecticide poisoning, we monitored the activity changes of cytochrome P450 monooxygenase, glutathione-S-transferase, and carboxylesterase in B. " 11/01/1992 - "[Biochemical aspects of the toxic effects of Supermethrin and the histochemical activity of alkaline phosphatase, acid phosphatase and non-specific esterase in subchronic poisoning in sheep]."
3.	Pancreatitis 01/01/1991 - "Based on a clinical study, elevated serum levels of the pancreatic lipolytic enzyme carboxylic ester hydrolase (CEH) was recently suggested to be a highly specific marker of acute pancreatitis. " 01/01/1989 - "The aim of this study was to obtain more information on the serum level of "nonspecific pancreatic carboxylesterase" (PCE) in experimentally induced acute pancreatitis in rats. " 05/01/2005 - "Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis." 01/01/1989 - "Activity of "nonspecific pancreatic carboxylesterase" in rat serum in experimentally induced acute pancreatitis (preliminary results)." 01/01/1987 - "By use of an enzyme-linked immunosorbent assay we established serum reference values of carboxylic ester hydrolase, a pancreatic secretory lipolytic enzyme, and explored to see if a raised serum level is indicative of acute pancreatitis. "
4.	Leukemia 01/01/2003 - "Classically, the monocytic component of acute myelomonocytic (FAB-M4) and acute monocytic/monoblastic (FAB-M5) leukemias is demonstrated by nonspecific esterase positivity in cytochemical stainings. " 01/01/1991 - "In the presence of 2 unit equiv of porcine liver carboxylate esterase, all of the compounds were hydrolyzed with half-lives of less than 1 min. Although closely structurally related, the compounds exhibited a wide range of cytotoxicities to L1210 murine leukemia cells in vitro." 12/01/1990 - "One case was diagnosed as myelomonocytic leukemia because the leukemic cells were highly positive for nonspecific esterase and negative for chrolacetate esterase. " 01/01/1989 - "The original leukemia had typical monocytic features, as evidenced by morphology (FAB M5), cytochemistry (nonspecific esterase) and immunophenotype (My4 positive). " 01/01/1985 - "One case of M4 (myelomonocytic) and the case of M5b (monocytic) leukemia revealed a complete lack of nonspecific esterase activity in CR monocytes as well as initial leukemic promonocytes; they also showed abnormally high or low concentrations of CFU-C and relapsed early. "
5.	Lymphoma (Lymphomas) 01/01/2000 - "However, in vitro chromosome damage and mutations are induced in mammalian cells lacking carboxylesterase activity (human lymphocytes and mouse lymphoma L5178Y cells). " 12/01/1984 - "In 41 lymphomas the presence of histiocytes was assessed with the aid of the non-specific esterase reaction. " 09/01/2001 - "In the current study, we explored the value of CD34, myeloperoxidase and nonspecific esterase (Leder) stains in differentiating GS from lymphomas. " 01/15/1989 - "Lymphomas associated with other strains of FeLV form rosettes with guinea pig erythrocytes, frequently have Ia antigens and cytoplasmic nonspecific esterase, and probably originate from helper T-cells, monocyte/macrophages, or null cells. " 11/01/1994 - "The lymphoma cells showed membrane positivity for alkaline phosphatase and diffuse cytoplasmic staining for acid phosphatase and non-specific esterase. "

Related Drugs and Biologics

1.	irinotecan (Camptosar)
2.	Type I DNA Topoisomerases (Topoisomerase I)
3.	Peroxidase (Myeloperoxidase)
4.	Acid Phosphatase
5.	Alkaline Phosphatase
6.	Enzymes
7.	Proteins (Proteins, Gene)
8.	Periodic Acid
9.	Halothane (Fluothane)
10.	Cholinesterases (Cholinesterase)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)