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Chromosomal Instability (Chromosome Stability)

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An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.

Also Known As:

Chromosome Stability; Chromosomal Stability; Chromosome Instability; Chromosomal Instabilities; Chromosomal Stabilities; Chromosome Instabilities; Chromosome Stabilities; Instabilities, Chromosomal; Instabilities, Chromosome; Instability, Chromosomal; Instability, Chromosome; Stabilities, Chromosomal; Stabilities, Chromosome; Stability, Chromosomal; Stability, Chromosome

Networked: 1717 relevant articles (9 outcomes, 114 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer)
2.	Neoplasms (Cancer)
3.	Microsatellite Instability
4.	Second Primary Neoplasms (Neoplasms, Second)
5.	Hypersensitivity (Allergy)

Experts

1.	Wise, Sandra S: 12 articles (10/2015 - 07/2006)
2.	Wise, John Pierce: 12 articles (10/2015 - 07/2006)
3.	Goel, Ajay: 12 articles (01/2015 - 11/2003)
4.	Sasaki, Kohsuke: 10 articles (01/2012 - 01/2002)
5.	Murnane, John P: 9 articles (02/2012 - 11/2002)
6.	Furuya, Tomoko: 9 articles (01/2012 - 01/2002)
7.	Hieter, Philip: 8 articles (11/2015 - 03/2002)
8.	Joenje, Hans: 8 articles (01/2015 - 02/2002)
9.	Fenech, Michael: 8 articles (01/2015 - 11/2002)
10.	Kawauchi, Shigeto: 8 articles (01/2012 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chromosomal Instability:

1.	Cisplatin (Platino)FDA LinkGeneric 07/03/1995 - "Transformants also showed partial correction of sensitivity to cisplatin and gamma-rays, efficient correction of chromosomal instability, and substantially improved plating efficiency and growth rate. " 10/01/2010 - "The objectives of this study were to evaluate the genotoxicity and mutagenicity of LT, and its protective effects in vivo against DNA damage and chromosome instability induced by cisplatin (cDDP). " 06/01/2003 - "A high level of chromosomal instability (high FAL value) defines a subset of patients who are more likely to benefit from cisplatin-based neoadjuvant chemotherapy. " 06/01/2003 - "Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma." 07/01/2003 - "Ovarian tumors often exhibit chromosome instability and hypersensitivity to the chemotherapeutic agent cisplatin. "
2.	DNA (Deoxyribonucleic Acid)IBA 10/01/2015 - "This model is supported by study results demonstrating superior chromosomal stability, telomere dynamics and DNA integrity in "successful agers". " 01/01/2015 - "In our previous study, a Met-to-Ile substitution at amino acid 256 in the catalytic domain of Uba1 was determined in temperature-sensitive CHO-K1 mutant tsTM3 cells, which exhibited chromosomal instability and cell-cycle arrest in the S to G2 phases with decreased DNA synthesis at the nonpermissive temperature, 39 °C. " 07/06/2010 - "These studies indicate that this deficiency is due to the reduced stability of alphaIISp and correlates with a decreased level of repair of DNA interstrand cross-links and chromosomal instability in FA cells. " 07/01/2007 - "Recent studies suggest that DNA hypomethylation may also control gene expression and chromosomal stability. " 09/01/2006 - "Our data support a direct link between genome-wide demethylation and chromosomal instability in human colorectal carcinogenesis and are consistent with the studies in model systems demonstrating a role of DNA demethylation in inducing chromosomal instability."
3.	Proteins (Proteins, Gene)IBA 02/01/2013 - "This study has attempted to clarify the possible involvement of both proteins in the reproductive problems of patients with chromosomal instability. " 11/01/2004 - "Recent studies suggest that BRCA proteins are required for maintenance of chromosomal stability, thereby protecting the genome from damage. " 10/01/2001 - "Recent studies reveal that the BRCA proteins are required for maintenance of chromosomal stability in mammalian cells and function in the biological response to DNA damage. " 07/01/2014 - "Here we report that LANA promoted the induction of chromosomal instability and the formation of micronuclei and multinucleation through its interaction with one of the critical spindle checkpoint proteins, Bub1, and the resulting degradation of Bub1. " 01/01/2014 - "Infected cells show dysregulation of the spindle assembly checkpoint proteins MAD1 and MAD2, impaired and prolonged M-phase, nuclear swelling, micronuclei formation and chromosomal instability. "
4.	N-methylsuccinimideIBA 11/01/2013 - "Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. " 10/01/2010 - "In 3.6% (n=27) of patients, CRC was attributed to 12 different inherited mutations in six known CRC-related genes associated with chromosomal instability or MSI pathways. " 12/01/2008 - "Three patients exhibited LOH and three other cases showed LOH with low level of MSI, being classified as having chromosome instability phenotype. " 11/01/2007 - "Three main pathways occur in the colorectal carcinogenesis (chromosomal instability [CIN] , MSI and CIMP), of which CIN represents the major part. " 11/01/2007 - "The association between CIMP and MSI as well as chromosomal instability(CIN) was examined. "
5.	Hydrocortisone (Cortisol)FDA LinkGeneric 01/01/2015 - "Cortisol was not associated with increased chromosomal instability, but caused a significant reduction in cell division and growth. " 01/01/2015 - "Cortisol is not associated with telomere shortening or chromosomal instability in human lymphocytes cultured under low and high folate conditions." 01/01/2015 - "This study tested the hypotheses that chronic exposure to the stress hormone, cortisol, causes telomere shortening and chromosome instability (CIN) in vitro, and that these effects would be further exacerbated by folate (vitamin B9) deficiency. "
6.	PoisonsIBA 08/14/2012 - "Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons." 05/01/2010 - "It is also required for proper cellular morphology, chromosome stability and following treatment with microtubule poisons. " 01/01/2008 - "We have previously shown that overexpression of TPPII correlates with chromosomal instability, centrosomal and mitotic spindle abnormalities and resistance to apoptosis induced by spindle poisons. " 10/01/2009 - "These breaks feature covalent linkage of the enzyme to the DNA termini by a 3'- or 5'-phosphotyrosyl bond and are implicated in hereditary human disease, chromosomal instability and cancer, and underlie the clinical efficacy of an important class of anti-tumour poisons. " 10/01/2012 - "The role of DNA double strand break (DSB) repair pathways, non-homologous end joining (NHEJ), and homologous recombination (HR) was evaluated to prevent the chromosome instability induced by the topoisomerase II (Top2) poisons, idarubicin, and etoposide in Chinese hamster cell lines. "
7.	TrypsinIBA 01/01/2011 - "Colorectal cancer is one of the most common malignancy in the world and the second cancer-related death, many molecular and genetic aspects of this disease have been cleared as chromosomal instability and the role of some key proteins as WNT/β catenin, trypsin and others. "
8.	Rutin (Rutoside)IBA 01/01/2012 - "In general, quercetin, isoquercitrin and rutin recovered the mitotic index and chromosomal instability more than quercitrin after treatment with hydrogen peroxide." 01/01/2012 - "Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H₂O₂ in human lymphocytes by analyzing cellular growth rate, cell viability, mitotic index and chromosomal instability. "
9.	QuercetinIBA 01/01/2012 - "In general, quercetin, isoquercitrin and rutin recovered the mitotic index and chromosomal instability more than quercitrin after treatment with hydrogen peroxide." 01/01/2012 - "Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H₂O₂ in human lymphocytes by analyzing cellular growth rate, cell viability, mitotic index and chromosomal instability. "
10.	LipidsIBA 06/01/2005 - "These results indicate that a combined antioxidant supplementation (a) is effective even at very moderate doses; (b) significantly diminishes oxidative damage to lipids when it is high initially; and (c) is effective in decreasing chromosomal instability in lymphocytes of middle-aged men."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/2010 - "The aim of this study was to evaluate possible signaling pathways involved in sensitization to chemotherapy in cells with chromosomal instability. " 05/01/2015 - "High-grade serous OC (HGSOC) is the most common and aggressive OC subtype, characterized by widespread genome changes and chromosomal instability and is consequently poorly responsive to chemotherapy treatment. " 07/23/2010 - "Re-introduction of miR-31 suppressed the cell cycle and inhibited expression of multiple factors involved in cooperative maintenance of DNA replication and cell cycle progression, including pro-survival phosphatase PPP6C, which was previously associated with chemotherapy and radiation therapy resistance, and maintenance of chromosomal stability. " 10/15/2009 - "Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy." 03/01/2005 - "Given the essential role of telomeres in regulating cellular aging and chromosomal stability, it is possible that the prematurely shortened telomeres that arise following chemotherapy may impact the long-term replicative potential of these tissues. "
2.	Chemoprevention 12/01/2005 - "This report focuses on establishing chromosome 9 polysomy as a cervical biomarker of chromosome instability and using it in a chemoprevention trial. " 12/01/2001 - "As part of several chemoprevention trials, biopsies were obtained from risk tissues (i.e., bronchial biopsies from chronic smokers, oral or laryngeal biopsies from individuals with premalignancy) and examined for chromosome instability using in situ hybridization. " 02/01/2013 - "Our findings that organo-Mg inhibits inflammation-related mouse colon carcinogenesis by modulating the proliferative activities and chromosomal instability of CRC and suppressing colonic inflammation may suggest potential use of organo-Mg for clinical chemoprevention trials of CRC in the inflamed colon."
3.	Aftercare (After-Treatment) 08/30/2012 - "These data indicate that SN induces delayed chromosomal instability in CHO cells, and that the in vitro clastogenic effect of this compound persists for at least 6 days but less than 15 days after treatment. " 11/01/1998 - "After treatment with DEB, lymphocytes showed an increase in the chromosomal instability in up to 20% of the analyzed in eight donors. " 09/01/1993 - "Increased frequencies were observed for many days after treatment, indicating that MN may be produced as a consequence of chromosomal instability transmitted by proliferating erythroblasts. " 01/01/2011 - "Growth inhibition and chromosomal instability of cultured marsupial (opossum) cells after treatment with DNA polymerase α inhibitor." 02/01/1996 - "The different spontaneous chromosome instability in clonal and non clonal cells together with their different behavior after treatment with only VP16, suggest that clonal cells bearing the tandem translocation could have increased faulty recombination. "
4.	Transplantation (Transplant Recipients) 04/01/2010 - "These cells have to be expanded in vitro before transplantation and several studies demonstrated that long-term culture evokes continuous changes in MSC: proliferation rate decays, the cell size increases, differentiation potential is affected, chromosomal instabilities may arise and molecular changes are acquired. " 04/01/2001 - "Chromosomal instability induced in vitro can be transmitted in vivo by transplantation of haemopoietic stem cells exposed to high- or low-LET radiations. " 02/01/1996 - "In the repopulated haemopoietic system we have observed persisting chromosomal instability up to 1 year post-transplantation. "
5.	Lasers (Laser) 12/01/2001 - "p53 Alteration and chromosomal instability in prostatic high-grade intraepithelial neoplasia and concurrent carcinoma: analysis by immunohistochemistry, interphase in situ hybridization, and sequencing of laser-captured microdissected specimens." 11/22/1974 - "Studies on chromosome stability and DNA constancy can be conducted with laser irradiated cells. " 01/01/2002 - "Chromosomal instability was estimated by numerical variation in chromosomes 7, 10 and 17 which was measured by fluorescence in situ hybridization (FISH), and DNA ploidy was determined by laser scanning cytometry. "