Oligoclonal Bands

Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.

Also Known As:

Networked: 670 relevant articles (15 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Owens, Gregory P: 10 articles (09/2012 - 10/2003)
2.	Villar, Luisa M: 9 articles (04/2015 - 01/2005)
3.	Burgoon, Mark P: 8 articles (06/2009 - 10/2003)
4.	Tumani, Hayrettin: 7 articles (07/2015 - 01/2010)
5.	Olsson, Tomas: 7 articles (07/2015 - 01/2013)
6.	Gilden, Donald H: 7 articles (11/2007 - 10/2003)
7.	Fujihara, Kazuo: 6 articles (12/2015 - 06/2004)
8.	Dale, Russell C: 5 articles (04/2015 - 11/2007)
9.	Vincent, Angela: 5 articles (04/2015 - 06/2010)
10.	Harbo, Hanne F: 5 articles (03/2015 - 01/2013)

Related Diseases

1.	Multiple Sclerosis 09/15/2000 - "Improved methods for the application of random peptide phage libraries to the study of the oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis." 01/01/2015 - "A study by Tintore et al. noted that 23% of patients who had normal MRI findings but had oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) developed clinically definite multiple sclerosis (CDMS), compared with 4% who had normal MRI findings but no OCBs in CSF (Tintore et al. 2008). " 05/01/2011 - "Similar to previous studies in adults, brain lesions detected on MRI and CSF oligoclonal bands in children are probable precursors to the clinical onset of multiple sclerosis. " 07/01/2010 - "The objective of the study was to evaluate whether the presence of oligoclonal bands (OB) adds information in predicting CIS conversion to clinical definite multiple sclerosis (CDMS) and conversion time to CDMS. " 01/01/2010 - "The importance of analysis of cerebrospinal fluid (CSF), especially oligoclonal IgG bands, in the diagnosis of multiple sclerosis (MS) and its predictive value in patients with clinically isolated syndromes has recently been evaluated and confirmed in several studies. "
2.	Multiple Myeloma 12/03/2009 - "Abnormal serum free light chain ratio in patients with multiple myeloma in complete remission has strong association with the presence of oligoclonal bands: implications for stringent complete remission definition." 11/01/2014 - "oligoclonal bands in patients with multiple myeloma: its emergence per se could not be translated to improved survival." 12/03/2009 - "This is the first report showing that the presence of oligoclonal bands in patients with multiple myeloma in CR frequently results in an abnormal FLC ratio. " 04/01/2011 - "Lack of correlation between emergence of an abnormal protein band or of oligoclonal bands and survival in patients with multiple myeloma achieving complete remission following autologous stem cell transplantation." 01/01/2011 - "Emergence of oligoclonal bands in patients with multiple myeloma in complete remission after induction chemotherapy: association with the use of novel agents."
3.	Leukocytosis (Pleocytosis) 02/01/2003 - "This form of MS generally has a higher age at onset and a higher female to male ratio than conventional MS. Opticospinal MS is also characterised by frequent relapses, severe disability, few brain lesions visible on MRI, long lesions extending over many vertebral segments visible on spinal-cord MRI, pleocytosis and an absence of oligoclonal bands in the CSF, and a pronounced shift in the responses of T-helper-1 and T-cytotoxic-1 cells throughout relapse and remission phases. " 06/01/2013 - "Cerebrospinal (CSF) studies at the time of ADEM showed a pleocytosis in six patients and were negative for oligoclonal bands (OCBs) in all. " 08/01/1995 - "CSF study revealed marked elevation of pleocytosis and oligoclonal IgG bands. " 12/01/2015 - "Cerebrospinal fluid pleocytosis and positive oligoclonal bands were documented. " 01/01/2014 - "Comprehensive work up was negative except for presence of a mild lymphocytic pleocytosis and oligoclonal bands in the CSF. "
4.	Measles 05/01/1997 - "Isoelectric focusing showed predominantly measles-specific oligoclonal IgG bands in the CSF. " 06/01/1985 - "Measles specific oligoclonal IgG bands were found in the sera and spinal fluids of these animals. " 11/01/1982 - "The samples showed dark brown measles-specific oligoclonal bands in the alkaline pH region of the gel, whereas the controls showed no significant staining. " 12/01/1979 - "Measles antibody level remained elevated, and oligoclonal IgG was present in both serum and CSF. " 08/01/1977 - "However, the nature of the correlation between occurrence of oligoclonal IgG and high measles antibody titre remains to be explained."
5.	Transverse Myelitis (Necrotizing Myelitis) 09/01/2003 - "Idiopathic RTM might be a disease entity distinct from MSRTM, differing in its male preponderance, absence of oligoclonal bands, frequent multiple relapses, and frequent presentation as acute transverse myelitis." 01/01/2014 - "Disease started with relapsing optic neuritis and an episode of longitudinally extensive transverse myelitis (LETM) in the absence of any brain MRI lesions or cerebrospinal fluid-restricted oligoclonal bands. " 06/01/2009 - "Studies of children after a first episode of demyelination have identified disease onset in adolescence, intrathecal oligoclonal bands and optic neuritis as associated with a higher MS risk, whereas prepubertal onset, presence of polyfocal features with encephalopathy, and transverse myelitis have been associated with a lower risk of subsequent MS. The relapsing-remitting form of MS accounts for over 96% of all MS in children. " 03/01/2005 - "Here, we report a case of acute transverse myelitis in a woman developing 4 years after documented HCV seropositivity, associated with intrathecal anti-HCV protein IgG. Isoelectrofocusing of all CSF samples before and after immunoabsorption with recombinant structural HCV proteins revealed disappearance or marked decrease of some oligoclonal IgG bands suggesting binding to HCV proteins. "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Proteins (Proteins, Gene)
4.	Sepharose (Agarose)
5.	Interferon-beta
6.	Immunoglobulins (Immunoglobulin)
7.	Immunoglobulin A (IgA)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Cyclophosphamide (Cytoxan)
10.	Immunosuppressive Agents (Immunosuppressants)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Stem Cell Transplantation
3.	Plasmapheresis
4.	Thymectomy
5.	Cell Transplantation