Cytochrome-B(5) Reductase (Methemoglobin Reductase)

A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.

Also Known As:

Networked: 109 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Siddiqi, N J: 4 articles (03/2002 - 07/2000)
2.	Srivastava, S: 4 articles (03/2002 - 07/2000)
3.	Alhomida, A S: 4 articles (03/2002 - 07/2000)
4.	Colah, Roshan B: 3 articles (03/2011 - 01/2002)
5.	Ghosh, Kanjaksha: 3 articles (03/2011 - 01/2002)
6.	Kedar, Prabhakar S: 3 articles (03/2011 - 01/2002)
7.	Pandey, V C: 3 articles (03/2002 - 05/2001)
8.	Poliakov, A V: 2 articles (04/2013 - 11/2012)
9.	Galeeva, N M: 2 articles (04/2013 - 11/2012)
10.	Warang, Prashant: 2 articles (03/2011 - 05/2008)

Related Diseases

1.	Parasitemia 05/01/2001 - "beta-Arteether treatment of infected mice resulted in complete clearance of parasitemia which also caused the restoration of methemoglobin and methemoglobin reductase system to near normal levels."
2.	Sarcoma (Soft Tissue Sarcoma) 12/01/1983 - "Extra-hepatic Walker sarcoma 256 produced a marked decrease (approximately 60%) in the levels of cytochrome P-450 and NADP-cytochrome P-450 reductase in rat liver endoplasmic reticulum, and a lesser decrease (approximately 20%) of cytochrome b5 and NADH-cytochrome b5 reductase. "
3.	Neoplasm Metastasis (Metastasis) 11/01/2015 - "NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer."
4.	Breast Neoplasms (Breast Cancer) 11/01/2015 - "NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer."
5.	Methemoglobinemia 01/01/1967 - "[Studies on congenital methemoglobinemia due to a dificiency of methemoglobin reductase in the red blood cells]." 11/01/2012 - "Hereditary types I and II methemoglobinemia is a rare autosomal recessive disease due to a deficiency of either soluble or soluble and membrane-bound forms of the enzyme NADH-cytochrome b5 reductase. " 08/15/2012 - "Recessive congenital methemoglobinemia (RCM) is a very rare disorder caused by NADH-cytochrome b5 reductase (cb5r) deficiency. " 04/15/2011 - "Congenital methemoglobinemia due to NADH-cytochrome b5 reductase 3 (CYB5R3) deficiency is an autosomal recessive disorder that occurs sporadically worldwide, although endemic clusters of this disorder have been identified in certain ethnic groups. " 07/01/2009 - "A novel L218P mutation in NADH-cytochrome b5 reductase associated with type I recessive congenital methemoglobinemia."

Related Drugs and Biologics

1.	Methemoglobin
2.	Cytochromes b5 (Cytochrome b5)
3.	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
4.	NADP (NADPH)
5.	Cytochrome P-450 Enzyme System (Cytochrome P450)
6.	Estrogens (Estrogen)
7.	arteether (artemotil)
8.	NAD (NADH)
9.	Hemoglobins (Hemoglobin)
10.	Oxidoreductases

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)