Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)

A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. It forms a complex with ELECTRON TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE.
Also Known As:
Medium-Chain Acyl-Coenzyme A Dehydrogenase; Acyl-coenzyme A Dehydrogenase; Medium Chain Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Medium-Chain; Fatty-acyl CoA Dehydrogenase; MCACA-Dehydrogenase; Medium-Chain Acyl-CoA Dehydrogenase; Octanoyl-CoA Dehydrogenase; Palmitoyl-CoA Dehydrogenase; Acyl CoA Dehydrogenase; Acyl coenzyme A Dehydrogenase; CoA Dehydrogenase, Fatty-acyl; Dehydrogenase, Acyl-CoA; Dehydrogenase, Acyl-coenzyme A; Dehydrogenase, Fatty-acyl CoA; Dehydrogenase, Medium-Chain Acyl-CoA; Dehydrogenase, Octanoyl-CoA; Dehydrogenase, Palmitoyl-CoA; Fatty acyl CoA Dehydrogenase; MCACA Dehydrogenase; Medium Chain Acyl CoA Dehydrogenase; Medium Chain Acyl Coenzyme A Dehydrogenase; Octanoyl CoA Dehydrogenase; Palmitoyl CoA Dehydrogenase
Networked: 151 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Young, Martin E: 4 articles (07/2008 - 05/2006)
2. Chandler, Margaret P: 4 articles (07/2008 - 05/2006)
3. McElfresh, Tracy A: 4 articles (07/2008 - 05/2006)
4. Hoit, Brian D: 4 articles (07/2008 - 05/2006)
5. Rennison, Julie H: 3 articles (07/2008 - 05/2006)
6. Stanley, William C: 3 articles (12/2006 - 05/2006)
7. Wajner, Moacir: 2 articles (05/2015 - 08/2003)
8. Opdal, Siri H: 2 articles (03/2011 - 10/2004)
9. Rognum, Torleiv O: 2 articles (03/2011 - 10/2004)
10. Wang, Feng: 2 articles (08/2010 - 08/2009)

Related Diseases

1. Reye Syndrome (Reye's Syndrome)
2. Anoxia (Hypoxia)
08/01/2003 - "To evaluate this metabolic switch, the transcriptional control of a cardiac FAO enzyme-encoding gene (medium-chain acyl-CoA dehydrogenase, MCAD) was characterized in response to hypobaric hypoxia. "
07/01/2000 - "Hypoxia per se induced a rise in hexokinase activity in all studied oxidative muscles and a fall of hydroxy-acyl CoA-dehydrogenase activity in both myocardial ventricles. "
03/01/1996 - "It was found that, in sedentary rats, hypoxia results in stunted growth, adrenal atrophy, a significant reduction of cross-sectional area of fast-twitch (type II) fibres, a reduced capillary-to-fibre ratio (C/F), and a reduced oxidative capacity (decreases in citrate synthase and 3-hydroxy-Acyl CoA dehydrogenase activities) of the plantaris muscle. "
08/01/2006 - "Hypoxia decreased the expression of enzymes involved in beta-oxidation (acyl-coenzyme A synthetase and acyl-coenzyme A dehydrogenase) and increased the expression of stearoyl-coenzyme A desaturase, an important enzyme in the fatty acid biosynthesis. "
02/01/2007 - "Our results demonstrate that 1) males sustain isometric force production (F) longer than females under hyperoxia (P O2 = 640 mmHg) with exogenous glucose present; 2) contractility is not maintained under moderate (P O2 = 130 mmHg) or severe hypoxia (P O2 = 10-20 mmHg) with glucose in either sex; however, following reoxygenation, F is higher in females compared with males; and 3) female tissue has higher lactate levels, net lactate efflux, and lactate dehydrogenase activity than males, whereas males have higher glycogen, citrate synthase, and beta-hydroxy acyl-CoA dehydrogenase activities, and greater inotropic responses to exogenous glucose and octanoate. "
3. Heart Failure
4. Atrophy
5. Sudden Infant Death (SID)

Related Drugs and Biologics

1. Citrate (si)-Synthase (Synthase, Citrate)
2. Carnitine (L-Carnitine)
3. Transferases
4. caprylic acid (octanoate)
5. Angiotensin II
6. Enzymes
7. Glucose (Dextrose)
8. Butyryl-CoA Dehydrogenase (Short-Chain Acyl-CoA Dehydrogenase)
9. Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)
10. Fatty Acids (Saturated Fatty Acids)

Related Therapies and Procedures

1. Transplants (Transplant)
2. Ligation