Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)

09/01/1995 - "[Population study of dihydropyrimidine dehydrogenase in cancer patients]."
11/01/1994 - "Population study of dihydropyrimidine dehydrogenase in cancer patients."
01/01/2008 - "Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients."
07/01/2006 - "Dihydropyrimidine dehydrogenase (DPD) is a reducing enzyme for fluoropyrimidine which is a widely-used anti-cancer agent, and its deficiency leads to serious toxicities. "
06/01/2006 - "Therefore, the administration of S-1 might be an effective strategy for the treatment of high dihydropyrimidine dehydrogenase-expressing tumors. "

08/10/2005 - "The study was to explore the dihydropyrimidine dehydrogenase (DPD) expression level in human colorectal carcinoma and its clinical implications. "
07/01/2006 - "Dihydropyrimidine dehydrogenase (DPD) is considered to be a key enzyme affecting the prognosis for patients with colorectal cancer. "
07/01/2006 - "The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer."
08/10/2005 - "[Expression of dihydropyrimidine dehydrogenase in human colorectal carcinoma and its clinical implications]."
01/01/2004 - "We studied the relation between clinicopathological factors and dihydropyrimidine dehydrogenase (DPD) activity in gastric and colorectal carcinomas. "

10/01/2000 - "[A preliminary study on dihydropyrimidine dehydrogenase activity in breast cancer]."
01/01/2004 - "We investigated dihydropyrimidine dehydrogenase (DPD) activity and its expression in breast cancer cases, and evaluated the prognostic significance of DPD expression in invasive breast cancer. "
03/01/2003 - "Increased dihydropyrimidine dehydrogenase activity in breast cancer."
01/21/2002 - "We have investigated dihydropyrimidine dehydrogenase expression as a prognostic marker in breast cancer. "
01/21/2002 - "Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer."

11/01/2004 - "Dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 may be effective against peritoneal dissemination in gastric cancer."
01/01/2012 - "T85C polymorphisms of dihydropyrimidine dehydrogenase in the peripheral blood of 112 Chinese gastric cancer patients were detected by real-time polymerase chain reaction combined with high-resolution melting curve technology. "
01/01/2012 - "Dihydropyrimidine dehydrogenase is a key enzyme acting on the metabolic pathway of medications for gastric cancer. "
01/01/2012 - "T85C polymorphisms of the dihydropyrimidine dehydrogenase gene detected in gastric cancer tissues by high-resolution melting curve analysis."
07/01/2006 - "[A case of recurrent gastric cancer with dihydropyrimidine dehydrogenase (DPD) deficiency]."

04/01/2011 - "To detect the expression of dihydropyrimidine dehydrogenase (DPD) in pancreatic ductal adenocarcinoma (PDAC), and to investigate the relationships between DPD expression and the prognosis of PDAC. "
04/01/2011 - "[Expression of dihydropyrimidine dehydrogenase negatively correlated with the prognosis of pancreatic ductal adenocarcinoma]."
08/01/2011 - "Prognostic impact of dihydropyrimidine dehydrogenase expression on pancreatic adenocarcinoma patients treated with S-1-based adjuvant chemotherapy after surgical resection."
09/01/2009 - "Prognostication of pancreatic adenocarcinoma by expression of thymidine phosphorylase/dihydropyrimidine dehydrogenase ratio and its correlation with survival."
07/01/2004 - "It is not known whether immunohistochemical quantification of dihydropyrimidine dehydrogenase (DPD) in cancer cells, stromal mononuclear cells and normal glands predicts the efficacy of fluorouracil (FU) derivatives inpatients with T3 gastric adenocarcinoma. "