Positive Transcriptional Elongation Factor B

A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.

Also Known As:

Networked: 109 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhou, Qiang: 9 articles (01/2020 - 02/2004)
2.	Lin, Chengqi: 5 articles (09/2012 - 02/2010)
3.	Shilatifard, Ali: 5 articles (09/2012 - 02/2010)
4.	Fujinaga, Koh: 4 articles (02/2020 - 10/2008)
5.	Luo, Kunxin: 4 articles (01/2020 - 03/2008)
6.	Lu, Huasong: 3 articles (01/2020 - 07/2014)
7.	Rice, Andrew P: 3 articles (01/2019 - 11/2002)
8.	Chaqour, Brahim: 3 articles (11/2012 - 07/2007)
9.	Siddiqui, M A Q: 3 articles (11/2012 - 07/2007)
10.	Smith, Edwin R: 3 articles (12/2011 - 02/2010)

Related Diseases

1.	Neoplasms (Cancer) 11/10/2023 - "Our study establishes the mechanistic underpinning for combinatorial targeting of CDK12 with either P-TEFb or the induced oncogenic pathways in cancer." 11/10/2023 - "In summary, stimulation of Pol II pause release at the signal-responsive genes underlies the functional dependence of CDK12-inhibited cancer cells on P-TEFb. " 01/01/2023 - "Brd4 inhibition synergizes with CDK9 inhibitor to suppress P-TEFb activity and tumor cell growth. " 01/01/2023 - "Together, co-targeting of P-TEFb and suppressors of intrinsic apoptosis could become a viable strategy to eliminate cancer cells." 10/01/2017 - "Our results suggest that Brd4 mediates most of the anti-cancer effects of JQ1 and that the major function of Brd4 in this process is the recruitment of P-TEFb. "
2.	Infections 01/01/2020 - "Most importantly, this supports the model that signal-mediated induction of SEC-P-TEFb levels can promote reactivation of a population of poised latent genomes.IMPORTANCE HSV infections can cause pathologies ranging from recurrent lesions to significant ocular disease. " 09/24/2010 - "Importantly, P-TEFb directs H1 phosphorylation in response to wild-type HIV-1 infection, but not Tat-mutant HIV-1 infection. " 06/22/1999 - "For this report, we studied the requirement for P-TEFb in HIV-1 infection, and we now show that P-TEFb is both essential and limiting for HIV-1 replication. " 02/01/2012 - "Activation of P-TEFb at sites of dual HIV/TB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime." 11/01/2010 - "Taken together, this study showed that P-TEFb and DENV core protein work in concert to enhance IL-8 gene expression by DENV infection. "
3.	Acquired Immunodeficiency Syndrome (AIDS) 02/14/2020 - "Studies on the mechanisms of Tat-dependent HIV transcription have led to radical advances in our knowledge regarding the mechanism of eukaryotic transcription, including the discoveries that P-TEFb-mediated elongation control of cellular transcription is a main regulatory step of gene expression in eukaryotes, and deregulation of P-TEFb activity plays critical roles in many human diseases and conditions in addition to HIV/AIDS. " 03/05/2013 - "These studies define the mechanism of scaffold recognition by P-TEFb and reveal an unanticipated intersubunit pocket on the AFF4 SEC that potentially represents a target for therapeutic intervention against HIV/AIDS. " 08/01/2018 - "P-TEFb and Brd4 have thus recently emerged as potential therapeutical targets for cancers and AIDS notably. " 06/01/2011 - "Given their roles in HIV-1/AIDS and cancer, further characterization of 7SK snRNP and SEC will help develop strategies to suppress aberrant transcriptional elongation caused by uncontrolled P-TEFb activation. " 05/01/2008 - "CDK9 is the kinase of the TAK complex (Tat-associated kinase complex), and binds to Tat protein of HIV, suggesting a possible role for CDK9 in AIDS progression. "
4.	Autosomal Dominant Polycystic Kidney (ADPKD) 01/01/2019 - "Our study therefore elucidates a mechanism by which P-TEFb activation by cAMP-PKA signaling promotes cystogenesis in ADPKD." 01/01/2019 - "The cAMP pathway plays central roles in the development of autosomal dominant polycystic kidney disease (ADPKD), and we show that P-TEFb is hyperactivated in mouse and human ADPKD kidneys. " 01/01/2019 - "Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease." 01/01/2019 - "Genetic activation of P-TEFb promotes cyst formation in a zebrafish ADPKD model, while pharmacological inhibition of P-TEFb attenuates cyst development by suppressing the pathological gene expression program in ADPKD mice. " 01/01/2022 - "Using integrative transcriptomic and cistromic analyses, they identify CRTC2-regulated cystogenesis-associated genes, whose activation depends on CRTC2 condensate-facilitated P-TEFb recruitment and the release of paused RNA polymerase II. Together, their findings elucidate a mechanism by which CRTC2 nuclear condensation conveys cAMP signaling to transcription elongation activation and thereby promotes cystogenesis in ADPKD."
5.	Thymoma (Thymic Carcinoma) 02/01/2008 - "In this study, using looping chromatin immunoprecipitation and chromatin conformation capture assays, we demonstrated that interactions between Runx1 and positive elongation factor b (P-TEFb) appose the silencer and enhancer in CD4-negative thymoma cells and double-negative immature thymocytes. "

Related Drugs and Biologics

1.	Positive Transcriptional Elongation Factor B
2.	alvocidib (flavopiridol)
3.	RNA Polymerase II (RNA Polymerase B)
4.	Proteins (Proteins, Gene)
5.	Peptide Elongation Factors (Elongation Factor)
6.	DNA (Deoxyribonucleic Acid)
7.	Cyclin-Dependent Kinases (cdk Proteins)
8.	Small Nuclear RNA (snRNA)
9.	Doxorubicin (Adriamycin)
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration