Angiopoietin-1

The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.

Also Known As:

Networked: 522 relevant articles (13 outcomes, 61 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Koh, Gou Young: 12 articles (04/2014 - 04/2006)
2.	Liles, W Conrad: 10 articles (09/2013 - 09/2007)
3.	Blann, Andrew D: 8 articles (08/2013 - 01/2004)
4.	Lip, Gregory Y H: 7 articles (08/2013 - 02/2004)
5.	Kümpers, Philipp: 7 articles (01/2013 - 01/2008)
6.	Chopp, Michael: 6 articles (10/2014 - 02/2002)
7.	Kain, Kevin C: 6 articles (09/2013 - 01/2009)
8.	Sun, Yu-Nien: 5 articles (06/2015 - 06/2010)
9.	Cho, Chung-Hyun: 5 articles (07/2013 - 04/2006)
10.	Kielstein, Jan T: 5 articles (01/2013 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2015 - "Angiopoietin-1 (Ang1) activation of Tie2 receptors on endothelial cells (ECs) reduces adhesion by tumor cells (TCs) and limits junctional permeability to TC diapedesis. " 01/09/2015 - "Finally, we illustrate an in situ measurement to detect Angiopoietin-1, a marker of tumor angiogenesis, accurately with this hybrid microcantilever at room temperature. " 12/20/2011 - "DA acts through its D(2) receptors present in these cells to up-regulate directly the expression of angiopoietin 1 (Ang1) in pericytes and the expression of the zinc finger transcriptional factor, Krüppel-like factor-2 (KLF2) in tumor endothelial cells. " 09/01/2011 - "Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis." 03/01/2011 - "Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the angiogenic switch. "
2.	Inflammation 04/28/2006 - "Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma leakage, inhibiting vascular inflammation, and preventing endothelial death. " 02/01/2014 - "We have recently reported that angiopoietin-1 (Ang1) reduces inflammation and vascular hyperpermeability in ALI animals. " 04/01/2013 - "Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization due to its ability to reduce endothelial permeability and inflammation. " 03/01/2012 - "Here we show that angiopoietin-1 (Ang1) enhances lymphatic integrity and function during inflammation. " 03/01/2012 - "Promotion of lymphatic integrity by angiopoietin-1/Tie2 signaling during inflammation."
3.	Sepsis (Septicemia) 08/01/2011 - "This result suggested that each angiopoietin-1 and -2 level may play a role in the pathogenesis of ALI and that PMX therapy ameliorates the angiopoietin balance in patients with ALI in sepsis." 01/01/2012 - "Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis." 01/01/2010 - "Does low angiopoietin-1 predict adverse outcome in sepsis?" 08/01/2011 - "Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis." 04/01/2009 - "Angiopoietin-1 in the treatment of ischemia and sepsis."
4.	Anoxia (Hypoxia) 01/01/2008 - "Furthermore, pSV-HIF1alpha induced the endogenous hypoxia-responsive genes such as angiopoietin-1, which would be beneficial for therapeutic angiogenesis. " 07/12/2013 - "In this study, we found that hypoxia increased Tie receptor expression but attenuated angiopoietin-1 (Ang1)-induced Tie2 activity, including Tie2 phosphorylation, Tie2 downstream signaling activation, and endothelial cell tube formation. " 05/01/2011 - "In the study, we constructed hypoxic response elements (HRE) and the Tet-On advanced double-controlled systems and investigated their effects on the expression of hVEGF165 and angiopoietin-1 (Ang-1) genes in rat cardiomyocytes exposed to hypoxia and pharmacologic induction. " 07/15/2012 - "Recombinant canstatin reduces the expression of angiopoietin-1 in hypoxia-induced CT-26 cells and inhibits the angiogenic and lymphangiogenic signaling induced by angiopoietin-1. " 12/15/2009 - "Overexpression of AEG-1 increases expression of molecular markers of angiogenesis, including angiopoietin-1, matrix metalloprotease-2, and hypoxia-inducible factor 1-alpha. "
5.	Brain Ischemia (Cerebral Ischemia) 05/16/2014 - "Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia." 03/01/2014 - "Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia." 01/01/2014 - "An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. " 05/01/2013 - "Human mesenchymal stem cells increases expression of α-tubulin and angiopoietin 1 and 2 in focal cerebral ischemia and reperfusion." 09/01/2010 - "Angiopoietin 1 counteracts vascular endothelial growth factor-induced blood-brain barrier permeability and alleviates ischemic injury in the early stages of transient focal cerebral ischemia in rats."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	AMG 386
3.	TIE-2 Receptor (Receptor, TIE 2)
4.	Proteins (Proteins, Gene)
5.	occludin
6.	cadherin 5
7.	Vascular Endothelial Growth Factor C
8.	Oleic Acid (Oleate)
9.	sildenafil (Viagra)
10.	Angiopoietin-2

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Vitrectomy
3.	Drug Therapy (Chemotherapy)
4.	Distraction Osteogenesis
5.	Microspheres (Microsphere)