Vascular Endothelial Growth Factors

A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.

Also Known As:

Networked: 326 relevant articles (8 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bremnes, Roy M: 4 articles (11/2015 - 02/2009)
2.	Busund, Lill-Tove: 4 articles (11/2015 - 02/2009)
3.	Alitalo, Kari: 4 articles (08/2013 - 09/2002)
4.	Ylä-Herttuala, Seppo: 4 articles (12/2012 - 05/2006)
5.	Al-Saad, Samer: 3 articles (11/2015 - 02/2009)
6.	Anisimov, Andrey: 3 articles (08/2013 - 12/2010)
7.	Shibuya, Masabumi: 3 articles (01/2013 - 03/2008)
8.	Donnem, Tom: 3 articles (03/2011 - 02/2009)
9.	Andersen, Sigve: 2 articles (11/2015 - 03/2011)
10.	Smith, Jonathan M: 2 articles (01/2015 - 01/2011)

Related Diseases

1.	Macular Edema 08/01/2009 - "Various studies have shown the possible benefits of intravitreal corticosteroids and anti-vascular endothelial growth factors in the treatment of diabetic macular edema. " 01/01/2015 - "Safety and efficacy of dexamethasone intravitreal implant (Ozurdex) for the treatment of persistent macular edema secondary to retinal vein occlusion in eyes previously treated with anti-vascular endothelial growth factors." 04/01/2014 - "Intravitreal corticosteroids and intravitreal anti-vascular endothelial growth factors are modalities of treatment for macular edema secondary to branch retinal vein occlusion (BRVO). " 01/01/2013 - "In recent years, many treatment options have been developed for clinical management of the complications of DR (e.g., proliferative DR and macular edema) using laser-based therapies, intravitreal corticosteroids and anti-vascular endothelial growth factors, and vitrectomy to remove scarring and hemorrhage, but all these have limited benefits. " 08/01/2015 - "Therapeutic strategies include improved blood supply, treatment of the vision-reducing macular edema by intravitreal injection of inhibitors of vascular endothelial growth factors (VEGF) or corticosteroids and laser photocoagulation for neovascular complications. "
2.	Retinal Vein Occlusion 01/01/2012 - "The objective of this review is to evaluate the evidence and discuss the rationale behind the recent suggestions that intravitreal pharmacotherapy by corticosteroids and anti-vascular endothelial growth factors may be useful in the treatment of retinal vein occlusion." 01/01/2015 - "Safety and efficacy of dexamethasone intravitreal implant (Ozurdex) for the treatment of persistent macular edema secondary to retinal vein occlusion in eyes previously treated with anti-vascular endothelial growth factors." 04/01/2014 - "Intravitreal corticosteroids and intravitreal anti-vascular endothelial growth factors are modalities of treatment for macular edema secondary to branch retinal vein occlusion (BRVO). " 01/01/2013 - "For this review, a search of PubMed from January 1989 to May 2013 was performed using the following terms (or combination of terms): vascular endothelial growth factors, VEGF, age-related macular degeneration, VEGF-Trap eye in wet AMD, VEGF-Trap eye in diabetic retinopathy, VEGF-Trap eye in retinal vein occlusions, aflibercept. " 03/01/2014 - "There are several treatment modalities for branch retinal vein occlusion and specifically for its complications, such as macular edema, vitreous hemorrhage, retinal neovascularization, and retinal detachment, including anti-aggregative therapy and fibrinolysis, isovolemic hemodilution, vitrectomy with or without sheathotomy, peripheral scatter and macular grid retinal laser therapy, non-steroid agents, intravitreal steroids, and intravitreal anti-vascular endothelial growth factors (anti-VEGFs)."
3.	Stomach Neoplasms (Stomach Cancer) 07/01/2011 - "The purpose of this study was to analyze the expression and prognostic significance of Aurora-A, VEGFs and VEGFRs in gastric cancer. " 06/01/2010 - "This study was designed to investigate the clinical significance of lymphangiogenic vascular endothelial growth factors C and D, and chemokine receptor CCR7 in the lymphatic spread of gastric cancer. " 06/01/2010 - "Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancer." 09/01/2014 - "Expression levels of vascular endothelial growth factors a and C in patients with peptic ulcers and gastric cancer." 07/01/2011 - "A randomized trial of somatostatin to regulate the VEGFs/VEGFRs in patients with gastric cancer."
4.	Colorectal Neoplasms (Colorectal Cancer) 09/01/2007 - "This study aimed at defining the expression of VEGFs in colorectal cancer (CRC) epithelia and their relationship to the metastatic status. " 01/01/2007 - "Vascular endothelial growth factors C and D represent novel prognostic markers in colorectal carcinoma using quantitative image analysis." 01/01/2006 - "Vascular endothelial growth factors and receptors in colorectal cancer: implications for anti-angiogenic therapy." 05/01/2004 - "Vascular endothelial growth factors C and D in colorectal cancers." 06/01/2003 - "Expression analysis of vascular endothelial growth factors and their relationships to lymph node metastasis in human colorectal cancer."
5.	Breast Neoplasms (Breast Cancer) 09/01/2010 - "Serum vascular endothelial growth factors a, C and d in human breast tumors." 01/01/2013 - "Alterations in cellular pathways related to both endocrine and vascular endothelial growth factors (VEGF) may contribute to breast cancer progression. " 03/01/2005 - "All VEGFs (VEGF-A, -B, -C and -D) were expressed in breast cancer cells, but at different levels. " 01/10/2005 - "The regulation of secretion of the angiogenic factors CXCL8 and Vascular Endothelial Growth Factors (VEGF) was determined in breast tumor cells and in monocytic cells (as host cells that contribute to breast cancer). " 01/01/2005 - "Angiogenesis and lymphangiogenesis are essential for breast cancer progression and are regulated by vascular endothelial growth factors (VEGF). "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Vascular Endothelial Growth Factors
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Intercellular Signaling Peptides and Proteins (Growth Factors)
5.	bevacizumab
6.	Epidermal Growth Factor (EGF)
7.	Platinum
8.	panitumumab (Vectibix)
9.	cetuximab (Erbitux)
10.	Nuclear Proteins (Protein, Nuclear)

Related Therapies and Procedures

1.	Intravitreal Injections
2.	Lasers (Laser)
3.	Light Coagulation
4.	Drug Therapy (Chemotherapy)
5.	Vitrectomy