Obstructive Jaundice (Cholestatic Jaundice)

Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.

Also Known As:

Networked: 2483 relevant articles (122 outcomes, 256 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Jaundice
2.	Neoplasms (Cancer)
3.	Stomach Neoplasms (Stomach Cancer)
4.	Endotoxemia
5.	Pathologic Constriction (Stenosis)

Experts

1.	Assimakopoulos, Stelios F: 14 articles (02/2011 - 05/2004)
2.	Vagianos, Constantine E: 10 articles (02/2011 - 05/2004)
3.	Sheen-Chen, Shyr-Ming: 9 articles (02/2015 - 01/2002)
4.	Kamisawa, Terumi: 9 articles (06/2014 - 07/2005)
5.	Eng, Hock-Liew: 9 articles (10/2010 - 01/2002)
6.	Miyazaki, Masaru: 8 articles (06/2014 - 04/2006)
7.	Chari, Suresh T: 8 articles (01/2014 - 03/2008)
8.	Scopa, Chrisoula D: 8 articles (02/2011 - 05/2004)
9.	Shimizu, Hiroaki: 7 articles (06/2014 - 04/2006)
10.	Li, Wen: 7 articles (04/2013 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Obstructive Jaundice:

1.	BilirubinIBA 03/01/1989 - "It was found that: (1) liver functions in the patients with obstructive jaundice were injured severely; bilirubin, R15ICG, m-GOT, and gamma-GT were increased significantly; (2) in patients with incomplete biliary obstruction or after the relief of obstruction, liver functions could be improved gradually. " 12/01/1996 - "The aim was to examine if delta-bilirubin reflects the duration of obstructive jaundice and efficacy of biliary drainage. " 08/21/2012 - "Patients were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels (total bilirubin > 2.0 mg/dL). " 03/01/2001 - "The present experimental study was carried out to determine variations in bilirubin and lipid metabolism in obstructive jaundice after external biliary drainage alone and in combination with intraintestinal administration of the drained bile. " 03/01/2001 - "Experimental study on lipid and bilirubin metabolism after biliary drainage for obstructive jaundice."
2.	perfluoro- 2,2,2',2'- tetramethyl- 4,4'- bis(1,3- dioxolane)IBA 03/01/2008 - "Percutaneous biliary drainage and stenting (PTBD) for palliation of malignant obstructive jaundice has evolved to a safe and effective technique. " 01/01/2013 - "Between 2007 and 2012, RVS-assisted PTBD was performed for 30 patients (19 males and 11 females; age range, 41 to 89 years; mean age, 66.9 years) with obstructive jaundice. " 12/15/2012 - "Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage." 12/01/2012 - "80 patients with obstructive jaundice who underwent IB-CEUS during PTBD were enrolled. " 11/01/2012 - "Percutaneous transhepatic biliary drainage(PTBD) was performed for obstructive jaundice. "
3.	Glutamine (L-Glutamine)FDA Link 01/01/2014 - "This study aimed to investigate the protective effects of postoperative nutrition with OLext and glutamine on bacterial translocation (BT) and liver damage in obstructive jaundice. " 01/01/2015 - "To evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. " 10/01/2005 - "Administration of glutamine has been proposed to maintain the integrity of the gut mucosa and thus reduce bacterial translocation (BT), but the effects of this pretreatment on apoptosis and histologic morphology of various organs affected by BT in obstructive jaundice have not been studied. " 07/01/2005 - "Beneficial effects of glutamine on intestinal barrier function in obstructive jaundice." 10/01/2004 - "We hypothesize that obstructive jaundice may alter serum TGFbeta1 and MCP-1 expressions in the rat and that oral bile acid or glutamine (or both) can restore the altered serum TGFbeta1 and MCP-1 expression in rats with obstructive jaundice. "
4.	CytokinesIBA 07/01/2012 - "Our study administered a modified major decoction of bupleurum in combination with exercise in rats with obstructive jaundice and the results indicated that applying a major bupleurum decoction in combination with moderately intense aerobic exercise showed a beneficial effect on adjusting the expression of liver inflammatory cytokines, which thus improved immunity and finally reduced the liver injury of rats with obstructive jaundice." 05/01/1999 - "These data demonstrate simultaneous impairment of Kupffer cell clearance of endotoxin and increased secretion of proinflammatory cytokines in experimental obstructive jaundice. " 05/01/1999 - "Kupffer cell clearance of endotoxin and secretion of cytokines in experimental obstructive jaundice were investigated. " 07/01/2012 - "Intervention of TLR4 signal pathway cytokines in severe liver injury with obstructive jaundice in rats." 01/01/2002 - "The ability of splenocytes and peritoneal exudate cells (PEC) to produce these cytokines both spontaneously and on induction with lipopolysaccharide (LPS), was compared in rats with and without obstructive jaundice (OJ). "
5.	PlasticsIBA 11/01/1990 - "Plastic biliary endoprostheses relieved malignant obstructive jaundice in 80% to 90% of the patients. " 09/01/2012 - "Twenty females and 23 males with a mean age of 64.8 years (range, 30-89 years) with malignant obstructive jaundice were referred to the interventional radiology department due to previously inserted dysfunctioning plastic endoprostheses. " 08/01/2005 - "Endoscopic insertion of plastic biliary endoprostheses is a well-established treatment for obstructive jaundice. " 10/01/1999 - "To evaluate the efficacy and complications of endoscopic drainage of malignant obstructive jaundice with plastic endoprosthesis as well as to identify possible factors related with occlusion. " 07/14/1992 - "Plastic biliary endoprostheses relief malignant obstructive jaundice in most patients sufficiently. "
6.	Propofol (Diprivan)FDA LinkGeneric 01/01/2011 - "The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice. " 01/01/2011 - "Low and intermediate concentrations of propofol did not appear to impair cardiac function in rats with obstructive jaundice." 01/01/2011 - "In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice." 11/01/2009 - "We demonstrated that obstructive jaundice with serum TBL from 7.8 to 362.7 micromol/l had no effect on propofol pharmacodynamics observed by BIS and MAP." 07/01/2009 - " conclude that in patients with obstructive jaundice the pharmacokinetics of propofol are similar to those of patients without obstructive jaundice."
7.	Glucose (Dextrose)FDA LinkGeneric 07/01/1999 - "This study was performed to investigate the concept of energy mediated by glucose, during the process of obstructive jaundice and its recovery. " 01/01/2002 - "The effects of obstructive jaundice on muscle glucose metabolism and expression of UCP2 in liver and muscle are unknown. " 01/01/2002 - "Obstructive jaundice results in increased liver expression of uncoupling protein 2 and intact skeletal muscle glucose metabolism in the rat." 03/01/1995 - "Hepatic mitochondrial response to oral glucose load (redox tolerance test) was evaluated as an indicator of hepatic functional reserve of patients with obstructive jaundice. " 04/01/1980 - "[Glucose metabolism on intravenous glucose tolerance test in obstructive jaundice (author's transl)]."
8.	gemcitabineFDA Link 07/01/2008 - "Gemcitabine didn't show to improve survival and QoL in patients with advanced PC previously treated with a covered metallic biliary endoprosthesis due to obstructive jaundice." 07/01/2008 - "Forty-nine patients with unresectable PC and obstructive jaundice, previously treated with the placement of a covered metal biliary endoprosthesis, were randomized to receive gemcitabine (group A: 9 males, 7 females) or to be followed without any anticancer intervention (group B: 18 males, 15 females). " 06/01/2009 - "Immediately after relief from obstructive jaundice, combination chemotherapy of S-1 and gemcitabine was given. " 08/01/2008 - "Gemcitabine therapy after endoscopic intervention was safe and effective in this case of recurrent gall bladder cancer with obstructive jaundice." 12/01/2003 - "Since obstructive jaundice had progressed rapidly, the patient received endoscopic nasobiliary drainage (ENBD) and stent-drainage therapy prior to chemotherapy using gemcitabine. "
9.	Intravenous AnestheticsIBA 03/28/2014 - "Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice." 03/28/2014 - "The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure." 11/01/2009 - "The effects of obstructive jaundice on the pharmacodynamics of propofol: does the sensitivity of intravenous anesthetics change among icteric patients?" 01/01/2012 - "In this study, we investigated the protective effects of frequently used intravenous anesthetics (ketamine, propofol, thiopental, and fentanyl) in oxidative stress in a rat liver model of obstructive jaundice. " 03/28/2014 - "To evaluate the protective effects on kidney tissue of frequently used intravenous anesthetics (ketamine, propofol, thiopental, and fentanyl) in rats with obstructive jaundice. "
10.	KetamineFDA LinkGeneric 03/01/2011 - "We report three cases of chronic ketamine misuse in three young men who all presented with obstructive jaundice and biliary tract abnormality. " 01/01/2012 - "The protective effects of ketamine and propofol in obstructive jaundice: an experimental study." 03/28/2014 - "Among the agents tested, ketamine and propofol generated the least amount of oxidative stres on renal tissues in this rat model of obstructive jaundice created by common bile duct ligation. " 03/28/2014 - "After 7 d, laparotomy was again performed using ketamine, propofol, thiopental, or fentanyl anesthesia whose antioxidative properties are well known in oxidative stress in a rat liver model of obstructive jaundice. " 01/01/2012 - "In this study, we investigated the protective effects of frequently used intravenous anesthetics (ketamine, propofol, thiopental, and fentanyl) in oxidative stress in a rat liver model of obstructive jaundice. "

Therapies and Procedures

1.	Stents 04/01/1990 - "The expandable metallic stent could be used for the effective treatment of obstructive jaundice." 07/25/2015 - "Our results showed that single-step endoscopic metal stent placement was safe and effective for treating obstructive jaundice secondary to various inoperable malignancies." 12/01/2011 - "One-step percutaneous transhepatic insertion of the Express LD stent is effective and safe for the management of obstructive jaundice caused by inoperable malignancies." 05/01/1996 - "The aim of this study was to analyze the clinical efficacy of metal stents in the palliation of malignant obstructive jaundice. " 11/01/2012 - "To evaluate the clinical efficacy of implanted biliary metallic stents in the management of malignant obstructive jaundice (MOJ). "
2.	Decompression 03/01/1977 - "This simple technique is found to be useful in the management of obstructive jaundice not only for preoperative decompression of biliary tree but also for the inoperable lesions." 04/01/1989 - "This study compares the efficacy of percutaneous transhepatic drainage (PTD) versus operative biliary decompression for patients with malignant obstructive jaundice. " 06/01/1984 - "Efficacy of preoperative biliary tract decompression in patients with obstructive jaundice." 10/01/2010 - "Bile duct decompression improves hepatocyte apoptosis and bile lakes in cases of severe obstructive jaundice, similar to the findings in animal studies." 10/01/2010 - "We conducted a "before and after study" on severe obstructive jaundice patients as a model of inhibition of the excessive process by bile duct decompression. "
3.	Drug Therapy (Chemotherapy) 05/01/2000 - "Studies regarding intraductal chemotherapy for patients with obstructive jaundice are still in the preliminary stages; therefore, no associated benefit could be ascertained. " 04/01/2011 - "In patients with obstructive jaundice, biliary drainage is often required in order to give treatments such as chemotherapy. " 07/01/2008 - "As to the patients with obstructive jaundice, percutaneous trans-hepatic cholangial drainage (PTCD) or bile duct endoprosthesis placement was performed first to improve the liver function, then HiTT was performed; and patients without obstructive jaundice underwent CT-guided HiTT directly, 1-2 weeks later, chemotherapy was given for 4 - 6 courses. " 04/01/2006 - "This may be in the form of surgical palliation (eg, palliative bypass for gastric outlet, bowel, or biliary tract obstruction), endoscopic biliary stenting (for obstructive jaundice), or palliative chemotherapy. " 10/01/2005 - "Obstructive jaundice and the need for some form of drainage procedure and dose modification of the chemotherapy are additional challenges. "
4.	Hepatectomy 03/01/1994 - "We studied 11C-MET-PET in 17 clinical cases, 10 patients with obstructive jaundice and 7 normal volunteers, and analyzed its efficacy for the evaluation of hepatic functional reserve in major hepatectomy candidates. " 10/01/2000 - "After preoperative percutaneous biliary drainage in obstructive jaundice, attempts have been made to reduce the volume of blood loss even in extensive hepatectomy, the extent of liver resection in poor risk cases has been reduced without sacrificing radicality, and, by minimizing surgical stress, perioperative management has been greatly improved." 06/01/2015 - "This study evaluates the outcome of hepatectomy for HCC with obstructive jaundice as a result of BDTT in non-cirrhotic livers. " 07/01/2012 - "The aim of this study was to observe the effects of flow-controlled partial portal vein arterializations (PPVA) on liver regeneration after hepatectomy in minipigs with chronic obstructive jaundice. " 04/07/2006 - "To study the effects of obstructive jaundice on liver regeneration after partial hepatectomy. "
5.	Parenteral Nutrition 05/01/2012 - "Early feeding resulted in shorter duration of parenteral nutrition and high-dependency care, lower incidence of cholestatic jaundice, and improved SD score for weight at discharge. " 05/01/1982 - "The cholestatic jaundice improved with the return to normal of liver function when the lipid emulsion dosage was reduced or intravenous feeding was discontinued." 12/08/1978 - "After parenteral nutrition had been discontinued obstructive jaundice cleared by the third month of life except in one infant. " 05/01/1980 - "Prospective controlled study of parenteral nutrition-associated cholestatic jaundice: effect of protein intake." 04/01/1995 - "Metabolic effect of parenteral nutrition in dogs with obstructive jaundice."