Neuropilin-1

Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.

Also Known As:

Networked: 293 relevant articles (1 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mukhopadhyay, Debabrata: 7 articles (06/2015 - 12/2003)
2.	Barberi-Heyob, Muriel: 6 articles (04/2015 - 05/2007)
3.	Frochot, Céline: 6 articles (04/2015 - 05/2007)
4.	Carmeliet, Peter: 6 articles (03/2013 - 02/2005)
5.	Zhang, Hua: 5 articles (09/2015 - 03/2014)
6.	Teesalu, Tambet: 5 articles (07/2015 - 12/2009)
7.	Guillemin, François: 5 articles (04/2015 - 05/2007)
8.	Banerjee, Snigdha: 5 articles (01/2010 - 10/2002)
9.	Banerjee, Sushanta K: 5 articles (01/2010 - 10/2002)
10.	Cao, Ying: 4 articles (06/2015 - 11/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2012 - "To compare the pharmacokinetics (PK) of MNRP1685A, a human monoclonal antibody (mAb) against neuropilin-1 (NRP1), in mice, rats, monkeys, and cancer patients from a Phase I study to model with parallel linear and nonlinear clearances. " 01/01/2015 - "In addition, miR-365 expression inversely correlated with NRP1 protein levels in MM. Our data suggest that miR-365 functions as a tumor suppressor in MM development and progression, and holds promise as a prognostic biomarker and potential therapeutic target for MM." 01/01/2015 - "In addition, miR-365 expression inversely correlated with NRP1 protein levels in MM. Our data suggest that miR-365 functions as a tumor suppressor in MM development and progression, and holds promise as a prognostic biomarker and potential therapeutic target for MM." 01/01/2015 - "iRGD is a tumor tissue penetrating peptide due to its targeted binding of integrin and neuropilin-1 receptors. " 06/01/2014 - "Neuropilin-1 (NRP-1) overexpression has been reported in a variety of human cancers. "
2.	Breast Neoplasms (Breast Cancer) 02/01/2010 - "This study examined PLGF-1, PGF-2 and its receptor neuropilin-1 levels in human breast cancer in relation to patient's clinical parameters and how changes in expression may be linked to prognosis of the disease. " 10/01/2015 - "We demonstrate that neuropilin-1 (NRP-1) expression is increased in breast cancer cells that overexpress GPNMB. " 10/28/2014 - "Here, we identified a breast cancer-targeting peptide CLKADKAKC (CK3) contains a cryptic C-end rule motif that may mediate its binding to neuropilin-1 (NRP-1), an attractive therapeutic target which expression was associated with poor outcome of the patients with breast cancer. " 01/01/2008 - "Our in vitro results suggest an autocrine effect of VEGF189 on breast cancer cells, probably through neuropilin-1. " 10/10/2002 - "Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: a possible marker for the progression of breast cancer."
3.	Neoplasm Metastasis (Metastasis) 02/01/2015 - "Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases." 01/28/2015 - "Moreover, we found that overexpression of exogenous microRNA-320b can up-regulate the target genes of microRNA-320a including β-catenin, Neuropilin-1 and Rac-1, which are all known to promote tumor proliferation, invasion and metastasis. " 07/01/2014 - "Neuropilin 1 is highly expressed in PDACs, and high expression of NRP-1 is significantly correlated with angiogenesis, advanced tumor-node-metastasis stage, p T stage, node invasion, and poor postoperative OS." 03/01/2004 - "Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract." 09/01/2015 - "This study addresses whether a population of metastasis-initiating cells (MICs) known to express a stronger RANKL, phosphorylated c-Met (p-c-Met), and neuropilin-1 (NRP1) signaling network than bystander or dormant cells (BDCs) can be detected in PC tissues from patients subjected to transurethral resection of the prostate (TURP) for urinary obstruction prior to the diagnosis of PC with or without prior hormonal manipulation, and whether the relative abundance of MICs over BDCs could predict castration-resistant progression and PC patient survival. "
4.	Melanoma (Melanoma, Malignant) 01/01/2015 - "Neuropilin-1 as Therapeutic Target for Malignant Melanoma." 10/22/2012 - "Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth." 03/15/2015 - "Cilengitide downmodulates invasiveness and vasculogenic mimicry of neuropilin 1 expressing melanoma cells through the inhibition of αvβ5 integrin." 07/01/2013 - "Neuropilin-1 expression promotes invasiveness of melanoma cells through vascular endothelial growth factor receptor-2-dependent and -independent mechanisms." 01/01/2012 - "The influence of neuropilin-1 silencing on semaphorin 3A and 3C activity in B16(F10) murine melanoma cells."
5.	Brain Neoplasms (Brain Tumor) 04/01/2015 - "For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. " 06/01/2014 - "In the present study, dual peptides-modified liposomes were designed by attaching two receptor-specific peptides, specifically low-density lipoprotein receptor-related protein receptor (Angiopep-2) and neuropilin-1 receptor (tLyP-1) for brain tumor targeting and tumor penetration. " 01/01/2014 - "In the present study, dual-modified liposomes (At-Lp) was designed by attaching two receptorspecific peptides, Angiopep and tLyP-1, which specifically targeting low-density lipoprotein receptor (LRP) for brain tumor targeting and neuropilin-1 receptor (NRP-1) for tumor penetration, respectively. "

Related Drugs and Biologics

1.	Integrins
2.	Dendrimers (Dendrons)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
5.	Liposomes (Liposome)
6.	Doxorubicin (Adriamycin)
7.	Carbon Monoxide
8.	Messenger RNA (mRNA)
9.	Phosphotransferases (Kinase)
10.	Peptides

Related Therapies and Procedures

1.	Transurethral Resection of Prostate (TURP)
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Castration
4.	Heterologous Transplantation (Xenotransplantation)
5.	Microbubbles