Neuropilins

Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.

Also Known As:

Networked: 131 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Klagsbrun, Michael: 7 articles (01/2011 - 01/2002)
2.	Tamagnone, Luca: 5 articles (03/2013 - 04/2007)
3.	Drabkin, Harry A: 4 articles (01/2014 - 05/2005)
4.	Roche, Joëlle: 4 articles (12/2013 - 01/2002)
5.	Staton, Carolyn A: 4 articles (05/2013 - 01/2010)
6.	Bielenberg, Diane R: 3 articles (11/2014 - 03/2006)
7.	Gemmill, Robert M: 3 articles (01/2014 - 05/2005)
8.	Nasarre, Patrick: 3 articles (01/2014 - 05/2005)
9.	Fowler, Ben: 3 articles (12/2010 - 07/2008)
10.	Maier, Julie: 3 articles (12/2010 - 07/2008)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2009 - "As data continue to accumulate pointing to a role for neuropilins in cancer, the promise for targeting this pathway is beginning to unfold." 08/28/2015 - "The penetration was tumor-specific, circulation-independent, and mediated by the neuropilin-binding RXXK tissue-penetration peptide motif of iRGD. " 03/01/2014 - "Enhancement of the tumor penetration of monoclonal antibody by fusion of a neuropilin-targeting peptide improves the antitumor efficacy." 03/01/2013 - "Here we provide an overview of neuropilin function in neurons and neural crest cells, discuss current knowledge of neuropilin signalling in the vasculature and conclude with a summary of neuropilin roles in cancer." 01/01/2013 - "EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin."
2.	Breast Neoplasms (Breast Cancer) 02/01/2010 - "Neuropilin transcript was below detection in substantial portion of the samples and was more frequently detected in high grade tumours (P=0.008 vs. low grade) and in tumours from patients who died of breast cancer (P<0.001 vs. those who remained disease-free). " 08/03/2004 - "VEGF165 binds to neuropilin, receptors for SEMA3B, and we found that SEMA3B competed for binding of 125I-VEGF165 to lung and breast cancer cells. " 07/28/2014 - "Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model." 08/01/2011 - "This study aimed to identify the involvement of class 3 semaphorins (Sema3) and receptors, neuropilins (Np1 and Np2) and plexins (A1-A4) in breast cancer development and angiogenesis. " 01/01/2013 - "To quantify heterogeneity in angiogenesis-related gene expression in breast cancer, we focused on two families--VEGFs and semaphorins--that compete for neuropilin co-receptors on endothelial cells. "
3.	Lung Neoplasms (Lung Cancer) 09/01/2015 - "Epigenetic targeting of the Neuropilin receptors may offer an effective treatment for lung cancer patients in the clinical setting." 12/01/2013 - "Here, we report that neuropilin (NRP)-2, the high-affinity receptor for SEMA3F and a coreceptor for certain growth factors, is upregulated during TGF-β1-driven EMT in lung cancer cells. " 05/01/2005 - "Although both antagonize VEGF binding/response to neuropilin (NRP) receptors, in lung cancer lines, SEMA3F is predominantly expressed and preferentially utilizes NRP2. "
4.	Colonic Neoplasms (Colon Cancer) 02/01/2006 - "The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer." 08/01/2006 - "In this study, transcripts encoding the VEGF-165 and semaphorin 3A (Sema3A) receptors and coreceptors Flt-1, KDR/Flk-1, plexin A1, and neuropilins NP-1 and NP-2 were identified by reverse transcription-PCR in the human colon cancer cell lines HCT8/S11, HT29, HCT116, and PCmsrc. "
5.	Schizophrenia (Dementia Praecox) 01/01/2011 - "A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population." 01/01/2011 - "We examined the association between schizophrenia and the neuropilin and tolloid-like 1 gene (NETO1). "

Related Drugs and Biologics

1.	Semaphorins (Semaphorin)
2.	plexin
3.	Proteins (Proteins, Gene)
4.	Ligands
5.	Semaphorin-3A
6.	human VEGFA protein
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
9.	Carbon Monoxide
10.	Vascular Endothelial Growth Factors

Related Therapies and Procedures

1.	Transplants (Transplant)