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Leukocyte L1 Antigen Complex (Calgranulin)

A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.
Also Known As:
Calgranulin; 27E10 Antigen; Calcium-Binding Myeloid Protein P8,14; Calprotectin; Migratory Inhibitory Factor-Related Protein MRP; Myelomonocytic Antigen L1; Antigen L1, Myelomonocytic; Antigen, 27E10; Antigen, L1; Calcium Binding Myeloid Protein P8,14; L1 Protein, Leukocyte; Migratory Inhibitory Factor Related Protein MRP; L1 Antigen; Leukocyte L1 Protein
Networked: 2727 relevant articles (196 outcomes, 412 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kolho, Kaija-Leena: 36 articles (11/2022 - 06/2006)
2. Day, Andrew S: 23 articles (01/2022 - 05/2006)
3. Sipponen, Taina: 22 articles (12/2020 - 01/2008)
4. Danese, Silvio: 19 articles (12/2022 - 08/2016)
5. Peyrin-Biroulet, Laurent: 18 articles (10/2022 - 09/2013)
6. Sandborn, William J: 18 articles (10/2022 - 11/2008)
7. Chazin, Walter J: 17 articles (01/2022 - 06/2002)
8. Färkkilä, Martti: 14 articles (11/2022 - 01/2008)
9. Heilmann, Romy M: 14 articles (05/2022 - 12/2012)
10. Skaar, Eric P: 14 articles (11/2020 - 02/2008)

Related Diseases

1. Crohn Disease (Crohn's Disease)
01/01/2021 - "Faecal calprotectin shows the most promise, with evidence to support its role in predicting relapse postsurgery and monitoring treatment response in patients with Crohn's disease. "
11/01/2021 - "CT Body composition measurements Results Argeny [24] 2018 Austria Retrospective cohort N = 95 N/A Crohn's disease CT; L3 level Visceral fat area (cm2) Visceral fat index (VFA/m2) No association between VFA or VFI and short-term post-operative outcomes Bryant [30] 2018 Australia Prospective cohort N = 110 N/A Crohn's disease and UC DXA Visceral adipose tissue (VAT) (cm3) Visceral adipose tissue (grams) VAT/height index (cm3/m2) VAT:subcutaneous adipose tissue ratio Fat mass index (kg/m2) VAT and VHI increased significantly over 24 months Bryant [13] 2018 Australia Prospective cohort N = 72 N/A Crohn's disease; female DXA Visceral adipose tissue (VAT) (cm3) Visceral adipose tissue (grams) VAT/height index (cm3/m2) VAT:subcutaneous adipose tissue ratio VAT:SAT positively associated with stricturing disease Adiposity not associated with fistulising disease phenotype VAT:SAT significantly associated with faecal calprotectin in L3 phenotype VAT:SAT significantly negatively associated with VHI and QoL over 24 months Buning [25] 2015 Germany Case control N = 50 N = 19 healthy controls Crohn's disease MRI US VAT Thickness of abdominal fat Distance to posterior wall of aorta Area of inferior part of perirenal fat VAT accumulation was higher in CD patients vs healthy controls VAT and VAT/fat mass ratio higher in patients in short-term remission vs long-term remission VAT/FM higher in stricturing/fistulising disease vs inflammatory subtype No association between VAT/FM and CDAI, HBI or anti-TNF treatment Connolly [26] 2014 US Retrospective cohort N = 143 N/A Crohn's disease CT (L1-L5 level) Visceral/intra-abdominal adiposity (VA) Subcutaneous adiposity (SA) VA not associated with post-operative morbidity Decreased SA and increased visceral/subcutaneous ratio were predictive of post-op complications. "
01/01/2019 - "There were statistically significant agreements between the absence of inflammatory criteria on MRE and remission according to the Harvey and Bradshaw index (HBI) (P = .037), the presence of inflammatory criteria on MRE and positive results for calprotectin (P = .005), and penetrating criteria on MRE and the scoring endoscopic system for Crohn's disease (SES-CD), indicating active disease (P = .048). "
12/01/2013 - "A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease."
05/01/2004 - "Calprotectin concentration was significantly greater in patients with Crohn's disease compared with controls (n = 25, P <0.001) and patients with IBS (n = 25, P <0.001). "
2. Inflammation (Inflammations)
3. Ulcerative Colitis
4. Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
5. Colitis

Related Drugs and Biologics

1. C-Reactive Protein
2. Biomarkers (Surrogate Marker)
3. Infliximab (Remicade)
4. Lactoferrin
5. Adrenal Cortex Hormones (Corticosteroids)
6. vedolizumab
7. Hemoglobins (Hemoglobin)
8. Albumins
9. Mesalamine (Mesalazine)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Therapeutics
2. Appendectomy
3. Knee Replacement Arthroplasty (Total Knee Replacement)
4. Biological Therapy
5. Hypnosis (Mesmerism)