Monoterpenes

Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).

Also Known As:

Networked: 97 relevant articles (4 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	de Sousa, Damião Pergentino: 3 articles (01/2015 - 05/2008)
2.	Schnitzler, Paul: 2 articles (06/2014 - 05/2010)
3.	Astani, Akram: 2 articles (06/2014 - 05/2010)
4.	Chiwakata, Maynard T: 2 articles (12/2012 - 06/2011)
5.	Beukes, Denzil R: 2 articles (12/2012 - 06/2011)
6.	Perumal, Srinivasan: 2 articles (10/2012 - 08/2012)
7.	Balasubramanian, Maruthaiveeran Periyasamy: 2 articles (10/2012 - 08/2012)
8.	Andersen, K E: 2 articles (03/2007 - 07/2002)
9.	Paulsen, E: 2 articles (03/2007 - 07/2002)
10.	Christensen, L P: 2 articles (03/2007 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/01/1997 - "In addition, monoterpenes are effective in treating early and advanced cancers. " 01/01/1995 - "Due to the therapeutic efficacy of monoterpenes in experimental model systems, clinical evaluation of this class of compounds has begun in advanced cancer patients. " 03/01/2002 - "Monoterpenes have been shown to be very effective chemopreventive agents against several rodent tumors and are currently in clinical trials. " 01/01/1999 - "Experimental studies, using animal cancer models, have demonstrated that some monoterpenes possess anticarcinogenic properties, acting at different cellular and molecular levels. " 11/03/2014 - "Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors."
2.	Inflammation 02/05/2015 - "Monoterpenes, as carvacrol (CARV), have been extensively studied about their therapeutic properties, especially their importance in the control of painful conditions and inflammation, which can be improved through the use of inclusion complexes of β-cyclodextrin (β-CD). " 11/17/1998 - "In summary, this is the first report on a new mechanism of action of monoterpenes suggesting 1.8-cineole as a strong inhibitor of cytokines that might be suitable for longterm treatment of airway inflammation in bronchial asthma and other steroid-sensitive disorders."
3.	Obesity 04/01/2016 - "Taken together, the selected monoterpenes may not confer strong protection against free radicals but nevertheless, their positive influence on lipid and glucose metabolism may have potential in the control of obesity and Type 2 diabetes mellitus. "
4.	Type 2 Diabetes Mellitus (MODY) 04/01/2016 - "Taken together, the selected monoterpenes may not confer strong protection against free radicals but nevertheless, their positive influence on lipid and glucose metabolism may have potential in the control of obesity and Type 2 diabetes mellitus. "
5.	Hypersensitivity (Allergy) 07/01/2002 - "The aims of this study were to test whether feverfew-allergic patients were also sensitive to some of the above-mentioned monoterpenes and, if so, to study associations between sensitization patterns, relevance of feverfew allergy and clinical features. " 10/01/2011 - "Monoterpenes isolated from Minthostachys verticillata (Griseb.) Epling essential oil modulates immediate-type hypersensitivity responses in vitro and in vivo." 03/01/2007 - "The aims of this study were to (i) assess the allergenicity of feverfew-derived monoterpenes and sesquiterpenes and their oxidized products in feverfew-allergic patients and (ii) re-assess the role of PHL and other SQLs in airborne contact allergy. " 06/01/2006 - "For the first time, the naturally occurring monoterpenes alpha-phellandrene, beta-phellandrene, and alpha-terpinene were demonstrated to be prohaptens able to induce contact allergy. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Free Radicals
3.	carvacrol
4.	limonene (d-limonene)
5.	perilla alcohol (perillyl alcohol)
6.	Volatile Oils (Essential Oils)
7.	perillic acid
8.	cineole (eucalyptol)
9.	Cyclin D1
10.	Sesquiterpenes

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)