Integrin beta4

Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.

Also Known As:

Networked: 113 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ahmed, A R: 5 articles (11/2007 - 02/2001)
2.	Zhao, Jing: 4 articles (04/2010 - 01/2008)
3.	Jones, Jonathan C R: 4 articles (06/2009 - 02/2003)
4.	Zhang, Shangli: 3 articles (04/2010 - 01/2008)
5.	Miao, Junying: 3 articles (04/2010 - 01/2008)
6.	Diaz, Leslie K: 3 articles (09/2005 - 02/2004)
7.	Gilcrease, Michael Z: 3 articles (09/2005 - 02/2004)
8.	Zhou, Xiao: 3 articles (09/2005 - 02/2004)
9.	Hashimoto, S: 2 articles (04/2010 - 08/2009)
10.	Muramatsu, T: 2 articles (04/2010 - 08/2009)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2006 - "A study by Guo et al. published recently in Cell indicates that the signaling function of beta4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. " 12/12/2008 - "Thus, ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin beta 4." 10/15/2008 - "The data suggested that these compounds might be promising agents for the cancer therapy, and these compounds would be useful tools for further investigate the functions of integrin beta4 in regulation of the cancer cell apoptosis." 10/01/2007 - "Targeting integrin beta4 for cancer and anti-angiogenic therapy." 10/13/2005 - "The integrin beta4 subunit has been shown to be involved in various aspects of cancer progression. "
2.	Adenocarcinoma 03/15/2000 - "In the present study, we demonstrate that the addition of a monoclonal antibody raised against the beta4 integrin subunit in the culture medium of a clone derived from the colon adenocarcinoma cell line LoVo specifically results in stimulation of cell migration and invasion through reconstituted basement membrane matrices. " 06/01/2005 - "Immunohistochemical detection of the beta4 integrin subunit in pancreatic adenocarcinoma." 01/01/1996 - "Variants of integrin beta 4 subunit in human endometrial adenocarcinoma cells: mediators of ECM-induced differentiation?" 06/01/2005 - "Forty-eight cases of pancreatic ductal adenocarcinoma were immunostained with a monoclonal antibody to the beta4 integrin subunit, and the extent of staining was compared with that seen in non-cancerous pancreatic tissues, including 15 separate cases of chronic pancreatitis and 6 sections from normal pancreas. " 01/01/1996 - "In the study presented here, we report that the reconstituted basement membrane, Matrigel, which induces morphological and functional differentiation of the endometrial adenocarcinoma cell line HEC 1B(L), also regulates the expression of various forms of the integrin beta 4 subunit. "
3.	Bullous Pemphigoid (Pemphigoid) 04/01/2003 - "Autoantibody in mucous membrane pemphigoid binds to an intracellular epitope on human beta4 integrin and causes basement membrane zone separation in oral mucosa in an organ culture model." 02/01/2003 - "We tested this notion by monitoring the fate of green fluorescent protein (GFP)-tagged human integrin beta4 subunit (GFP-hbeta4) and GFP-tagged 180-kD human bullous pemphigoid (BP) autoantigen (GFP-BP180) in live cultures of 804G cells that assemble numerous mature hemidesmosomes. " 07/01/2006 - "Previous studies have shown that sera of patients with MMP bind to human integrin beta4, while sera of patients with oral pemphigoid bind to the integrin alpha6 component of the heterodimer. " 06/01/2009 - "Here, we tested the hypothesis that the beta4 integrin-associated plakin protein, bullous pemphigoid antigen 1e (BPAG1e) functions as a scaffold for Rac1/cofilin signal transduction. " 09/01/2007 - "The binding of BP180 with either integrin alpha6, integrin beta4, or bullous pemphigoid antigen-1 (BPAG1/BP230) is critical for this attachment in skin. "
4.	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 10/01/2003 - "In this study we examined two unrelated patients affected with the lethal variant of junctional epidermolysis bullosa with pyloric atresia (PA-JEB) who were found to carry mutations in the integrin beta4 subunit gene (ITGB4). " 01/01/2015 - "Whole-genome sequencing identifies a homozygous deletion encompassing exons 17 to 23 of the integrin beta 4 gene in a Charolais calf with junctional epidermolysis bullosa." 10/01/2004 - "Intracellular degradation of beta4 integrin in lethal junctional epidermolysis bullosa with pyloric atresia." 01/01/2004 - "Pyloric atresia-junctional epidermolysis bullosa syndrome showing novel 594insC/Q425P mutations in integrin beta4 gene (ITGB4)." 10/01/2003 - "Novel and recurrent mutations in the integrin beta 4 subunit gene causing lethal junctional epidermolysis bullosa with pyloric atresia."
5.	Neoplasm Metastasis (Metastasis) 10/01/2009 - "In this study, we showed that expression of the beta4 integrin in MDA-MB-435 cancer cells (MDA-MB-435/beta4) leads to a dramatic increase in expression of a metastasis-promoting factor, S100A4, as determined by affymetrix gene chip microarray, quantitative real-time PCR, and Western blot analysis. " 01/15/2008 - "These data support the inhibitory effect of apigenin on HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and integrin beta 4 function." 09/01/2004 - "Furthermore, loss of adhesion expressed by low E-cadherin and integrin beta4 correlated with the presence of nodal metastases at the time of diagnosis." 09/24/2009 - "These data begin to integrate ezrin and beta4 integrin expression into a model of action for the mechanism of osteosarcoma metastases." 09/24/2009 - "Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin."

Related Drugs and Biologics

1.	Integrin alpha6
2.	Small Interfering RNA (siRNA)
3.	Autoantibodies
4.	Cadherins (E-Cadherin)
5.	matrigel
6.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
7.	Acridine Orange
8.	kalinin
9.	Antigens
10.	Plectin

Related Therapies and Procedures

1.	Prostatectomy (Retropubic Prostatectomy)
2.	Lasers (Laser)
3.	Gingivectomy