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Integrin beta3 (GPIIIa)

Subscribe to New Research on Integrin beta3

An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.

Also Known As:

GPIIIa; CD61 Antigen; Platelet GPIIIa; Platelet Glycoprotein IIIa; beta(3) Integrin; beta3 Integrin; beta3A Integrin; beta3B Integrin; beta3C Integrin; Antigen, CD61; Glycoprotein IIIa, Platelet; Integrin, beta3; Integrin, beta3A; Integrin, beta3B; Integrin, beta3C; beta3, Integrin; Antigens, CD61; CD61 Antigens; Integrin beta3A; Integrin beta3B; Integrin beta3C; Platelet Membrane Glycoprotein IIIa

Networked: 646 relevant articles (11 outcomes, 71 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Boerman, Otto C: 7 articles (12/2009 - 11/2002)
2.	Schwaiger, Markus: 7 articles (12/2009 - 01/2004)
3.	Dijkgraaf, Ingrid: 6 articles (12/2009 - 11/2002)
4.	Zhang, Wei: 5 articles (10/2012 - 03/2006)
5.	Haubner, Roland: 5 articles (12/2009 - 01/2005)
6.	Aster, Richard H: 4 articles (06/2015 - 02/2003)
7.	Ross, F Patrick: 4 articles (07/2010 - 12/2005)
8.	Ghandehari, Hamidreza: 4 articles (11/2009 - 09/2005)
9.	Oyen, Wim J G: 4 articles (10/2009 - 11/2006)
10.	Tang, Chih-Hsin: 4 articles (08/2009 - 12/2007)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2009 - "Thus, with alpha(v)beta(3) integrin being identifiable primarily on angiogenic ECs and SK-1 being highly expressed in tumors, targeting SK-1 may affect multiple survival pathways, and its inhibition may be highly efficacious in controlling pathological EC survival." 02/01/2002 - "We found that immunogene therapy of tumors with a vaccine based on the ligand-binding domain of chicken integrin beta3 (P-BD-C) was effective in both protective and therapeutic anti-tumor immunity in several tumor models in mice. " 11/01/2008 - "This study identifies tumor cell alpha(v)beta(3) integrin as an attractive target and defines the Akt pathway as a predictor of response to function-blocking antibody." 09/01/2004 - "MRI studies using this targeted contrast agent revealed large areas of alpha(v)beta3 integrin expression in tumor-associated vasculature that conventional MRIs failed to show. " 06/01/2001 - "Studies on the expression of alpha(v)beta3 integrin receptors in non-malignant and malignant human cervical tumor tissues."
2.	Melanoma (Melanoma, Malignant) 06/01/2001 - "Large numbers of studies have been done to establish the role of alpha(v)beta3 integrin receptor in human melanoma systems. " 06/15/1997 - "In this study, we questioned whether human melanoma cells express the alphaIIb beta3 integrin. " 12/01/1996 - "Recent in situ studies suggest the alpha V beta 3 integrin is a tumour progression marker in melanoma. " 10/01/2006 - "On the other hand, MCAM and beta3 integrin are the two adhesion molecules that play a pivotal role in melanoma cell migration and invasion, and for this reason, may represent valuable targets for melanoma therapy." 08/15/2006 - "Finally, a functional role for Rap1 activation was shown by Rap1-induced alpha(v)beta(3) integrin activation and consequent increased melanoma cell migration in vitro. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2010 - "MCF-7 breast cancer cells expressing the α(v)β(3) [alpha(v)beta(3)] integrin receptor are considered as appropriate candidates for such a targeted therapy. " 02/01/2007 - "The results from the in vivo and in vitro experiments allow the conclusion that the presence of beta3 integrin in MDA-MB-231 breast cancer cells induced an increased MMP-2 expression and activity that might contribute to the enhanced invasive potential observed." 02/01/2007 - "Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the beta3 integrin subunit." 01/01/2007 - "These findings were verified with Western immunoblotting by the higher expression of integrin beta3 subunit and actin in primary breast cancer cells, revealing their reciprocal relation, in response to the higher motility requirements, determined by the malignant potential of the breast cancer cells. " 10/01/2006 - "A bidirectional "alpha(v)beta(3) integrin-ERK1/ERK2 MAPK" connection regulates the proliferation of breast cancer cells."
4.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2009 - "To investigate the role of integrin beta3 in invasive features of ovarian cancer SKOV3 cells, by comparing different metastatic subclones. " 07/01/2009 - "Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones." 06/01/2007 - "Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk." 12/01/2005 - "Increased risk of ovarian cancer in integrin beta3 Leu33Pro homozygotes." 03/01/2001 - "Loss of alpha(v)beta(3) integrin is frequently associated with advanced stages of ovarian cancer and can significantly reduce ATE."
5.	Retinal Degeneration 03/01/2009 - "This study was conducted to investigate the question of whether the lack of beta5 and/or beta3 integrin subunits might influence the course of retinal degeneration and/or clearance of photoreceptor debris induced by acute exposure to light. "

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4.	cyclic arginine-glycine-aspartic acid peptide
5.	CD29 Antigens
6.	Immunoglobulin G (IgG)
7.	Cilengitide
8.	EMD 121974
9.	Fibronectins (Fibronectin)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Radiotherapy
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3.	Microbubbles
4.	Transplants (Transplant)
5.	Ligation